YPL073C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL073C / YPL073C

Click on Significant Values for Screen Details ID:SGTC_145|Compound:3737-0113|FD-Score:3.29|P-value:1.66E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.62|P-value:3.59E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:4.57|P-value:3.10E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:3.06|P-value:4.22E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.23|P-value:1.99E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.12|P-value:3.27E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.85|P-value:1.35E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:-4.26|P-value:1.50E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.09|P-value:3.53E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-2.88|P-value:7.79E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.56|P-value:4.75E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.24|P-value:2.07E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.95|P-value:6.10E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.57|P-value:4.90E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.39|P-value:1.02E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.67|P-value:2.83E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.88|P-value:1.15E-5 ID:SGTC_1709|Compound:st033179|FD-Score:3.29|P-value:1.63E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.51|P-value:6.37E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.30|P-value:1.49E-4 ID:SGTC_1748|Compound:st037455|FD-Score:2.91|P-value:7.52E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.28|P-value:1.72E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.23|P-value:2.09E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.12|P-value:3.40E-4 ID:SGTC_1921|Compound:5740136|FD-Score:2.89|P-value:8.02E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.17|P-value:2.76E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.80|P-value:1.68E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.75|P-value:2.13E-5 ID:SGTC_2166|Compound:5933061|FD-Score:4.02|P-value:5.67E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.52|P-value:5.64E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.74|P-value:2.09E-5 ID:SGTC_2255|Compound:7941087|FD-Score:4.31|P-value:1.25E-6 ID:SGTC_2355|Compound:9061122|FD-Score:3.13|P-value:3.15E-4 ID:SGTC_2415|Compound:st077333|FD-Score:5.41|P-value:1.68E-9 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.10|P-value:3.37E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.19|P-value:2.42E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.48|P-value:7.24E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.98|P-value:5.71E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.78|P-value:1.71E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-3.38|P-value:1.03E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.60|P-value:3.89E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.89|P-value:1.08E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-3.69|P-value:2.57E-5 ID:SGTC_2938|Compound:9059746|FD-Score:2.98|P-value:5.72E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.18|P-value:2.44E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.23|P-value:2.13E-4 ID:SGTC_3076|Compound:9116187|FD-Score:4.20|P-value:2.24E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.17|P-value:2.50E-4 ID:SGTC_3284|Compound:9108171|FD-Score:4.67|P-value:1.75E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:3.29|P-value:1.66E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.62|P-value:3.59E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:4.57|P-value:3.10E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:3.06|P-value:4.22E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.23|P-value:1.99E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.12|P-value:3.27E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.85|P-value:1.35E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:-4.26|P-value:1.50E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.09|P-value:3.53E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-2.88|P-value:7.79E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.56|P-value:4.75E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.24|P-value:2.07E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.95|P-value:6.10E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.57|P-value:4.90E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.39|P-value:1.02E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.67|P-value:2.83E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.88|P-value:1.15E-5 ID:SGTC_1709|Compound:st033179|FD-Score:3.29|P-value:1.63E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.51|P-value:6.37E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.30|P-value:1.49E-4 ID:SGTC_1748|Compound:st037455|FD-Score:2.91|P-value:7.52E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.28|P-value:1.72E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.23|P-value:2.09E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.12|P-value:3.40E-4 ID:SGTC_1921|Compound:5740136|FD-Score:2.89|P-value:8.02E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.17|P-value:2.76E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.80|P-value:1.68E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.75|P-value:2.13E-5 ID:SGTC_2166|Compound:5933061|FD-Score:4.02|P-value:5.67E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.52|P-value:5.64E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.74|P-value:2.09E-5 ID:SGTC_2255|Compound:7941087|FD-Score:4.31|P-value:1.25E-6 ID:SGTC_2355|Compound:9061122|FD-Score:3.13|P-value:3.15E-4 ID:SGTC_2415|Compound:st077333|FD-Score:5.41|P-value:1.68E-9 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.10|P-value:3.37E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.19|P-value:2.42E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.48|P-value:7.24E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.98|P-value:5.71E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.78|P-value:1.71E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-3.38|P-value:1.03E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.60|P-value:3.89E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.89|P-value:1.08E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-3.69|P-value:2.57E-5 ID:SGTC_2938|Compound:9059746|FD-Score:2.98|P-value:5.72E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.18|P-value:2.44E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.23|P-value:2.13E-4 ID:SGTC_3076|Compound:9116187|FD-Score:4.20|P-value:2.24E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.17|P-value:2.50E-4 ID:SGTC_3284|Compound:9108171|FD-Score:4.67|P-value:1.75E-7

Top fitness defect scores for YPL073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2415 st077333 5.41 57.7 µM 1.68E-9 15 3.07E-8
2 SGTC_3284 9108171 4.67 64.9 µM 1.75E-7 12 1.53E-6
3 SGTC_519 k048-0011 4.57 62.8 µM 3.10E-7 10 2.48E-6
4 SGTC_2255 7941087 4.31 197.4 µM 1.25E-6 22 8.03E-6
5 SGTC_3076 9116187 4.20 49.5 µM 2.24E-6 15 1.32E-5
6 SGTC_2426 5582046 4.19 32.2 µM 2.42E-6 22 1.40E-5
7 SGTC_2166 5933061 4.02 31.5 µM 5.67E-6 tubulin folding & SWR complex 43 2.88E-5
8 SGTC_2742 clothiapine 3.89 36.3 µM 1.08E-5 NEO1 12 4.96E-5
9 SGTC_1631 benzylvanillin 3.88 81.9 µM 1.15E-5 Golgi 30 5.22E-5
10 SGTC_1003 4049-0218 3.85 100.0 µM 1.35E-5 21 5.99E-5
11 SGTC_1929 genistein trimethyl ether 3.80 50.5 µM 1.68E-5 20 7.22E-5
12 SGTC_2014 4013930 3.75 200.0 µM 2.13E-5 40 8.81E-5
13 SGTC_1304 1165-0502 3.57 251.0 µM 4.90E-5 77 1.78E-4
14 SGTC_1726 st035556 3.51 14.6 µM 6.37E-5 55 2.23E-4
15 SGTC_2564 betulinic acid 3.48 100.0 µM 7.24E-5 46 2.48E-4
16 SGTC_1709 st033179 3.29 39.1 µM 1.63E-4 35 4.93E-4
17 SGTC_145 3737-0113 3.29 38.4 µM 1.66E-4 DNA intercalators 112 5.02E-4
18 SGTC_1813 st051246 3.28 8.6 µM 1.72E-4 TSC3-RPN4 19 5.17E-4
19 SGTC_1230 0170-0365 3.24 3.8 µM 2.07E-4 endomembrane recycling 114 6.04E-4
20 SGTC_1815 st051655 3.23 58.2 µM 2.09E-4 TSC3-RPN4 21 6.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.03E-14 YDR248C_p YDR248C_p hom Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
0.116 1.46E-11 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.108 3.44E-10 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.107 4.90E-10 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.106 6.59E-10 YLR011W LOT6 hom FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
0.100 6.33E-9 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.095 3.24E-8 YMR093W UTP15 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.091 1.17E-7 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.089 2.08E-7 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
0.084 1.21E-6 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.081 2.33E-6 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.081 2.37E-6 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.081 2.73E-6 YDL011C_d YDL011C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
0.080 3.04E-6 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.080 3.41E-6 YOL075C_p YOL075C_p hom Putative ABC transporter