YPL074W / YTA6

Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL074W / YTA6

Click on Significant Values for Screen Details ID:SGTC_105|Compound:0111-0055|FD-Score:3.28|P-value:5.30E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.30|P-value:7.05E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:2.70|P-value:6.83E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:6.22|P-value:1.27E-13 ID:SGTC_274|Compound:sirtinol|FD-Score:-2.95|P-value:3.48E-4 ID:SGTC_398|Compound:bronopol|FD-Score:2.65|P-value:8.31E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.55|P-value:1.34E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:-2.74|P-value:8.07E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.63|P-value:9.01E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.31|P-value:4.43E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:5.24|P-value:3.30E-10 ID:SGTC_781|Compound:4335-2806|FD-Score:2.75|P-value:5.51E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.22|P-value:3.22E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:2.85|P-value:3.69E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:2.61|P-value:9.65E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.96|P-value:3.36E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.56|P-value:1.29E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:2.68|P-value:7.46E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:2.77|P-value:5.06E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.32|P-value:4.28E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:-2.75|P-value:7.93E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.01|P-value:1.79E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.13|P-value:1.06E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:2.74|P-value:5.72E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:5.66|P-value:1.36E-11 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.17|P-value:1.34E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.86|P-value:3.54E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.94|P-value:2.45E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-2.70|P-value:9.79E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.87|P-value:2.41E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.08|P-value:2.02E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.84|P-value:5.56E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.88|P-value:4.36E-9 ID:SGTC_1654|Compound:st012436|FD-Score:-3.37|P-value:5.27E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.30|P-value:1.95E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-4.06|P-value:1.34E-6 ID:SGTC_1790|Compound:st045711|FD-Score:-2.73|P-value:8.69E-4 ID:SGTC_1791|Compound:st048313|FD-Score:2.99|P-value:1.94E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.46|P-value:2.13E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.76|P-value:1.00E-8 ID:SGTC_2068|Compound:5226020|FD-Score:4.96|P-value:2.53E-9 ID:SGTC_2165|Compound:5727197|FD-Score:3.80|P-value:3.66E-6 ID:SGTC_2239|Compound:6685329|FD-Score:2.64|P-value:8.69E-4 ID:SGTC_2276|Compound:7947513|FD-Score:2.96|P-value:2.27E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-4.92|P-value:6.45E-9 ID:SGTC_2318|Compound:6029776|FD-Score:-2.83|P-value:5.75E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.37|P-value:3.31E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.10|P-value:1.20E-4 ID:SGTC_2340|Compound:7987427|FD-Score:7.11|P-value:3.46E-17 ID:SGTC_2344|Compound:7990960|FD-Score:-4.35|P-value:2.45E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.74|P-value:7.78E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.32|P-value:3.53E-10 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.16|P-value:1.35E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.71|P-value:5.98E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.37|P-value:5.11E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.03|P-value:1.62E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.09|P-value:1.24E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.17|P-value:1.96E-13 ID:SGTC_2484|Compound:5809818|FD-Score:-3.22|P-value:1.03E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:2.77|P-value:5.07E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-2.77|P-value:7.17E-4 ID:SGTC_2671|Compound:danthron|FD-Score:2.81|P-value:4.29E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.28|P-value:2.16E-7 ID:SGTC_2691|Compound:st077356|FD-Score:3.20|P-value:7.46E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.41|P-value:4.31E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-5.93|P-value:3.06E-12 ID:SGTC_2875|Compound:9039966|FD-Score:-3.27|P-value:8.13E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.13|P-value:1.05E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-2.72|P-value:8.82E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.63|P-value:8.88E-6 ID:SGTC_3220|Compound:9131269|FD-Score:2.80|P-value:4.53E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.10|P-value:6.61E-7 ID:SGTC_3331|Compound:9141060|FD-Score:-2.94|P-value:3.59E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.28|P-value:5.30E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.30|P-value:7.05E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:2.70|P-value:6.83E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:6.22|P-value:1.27E-13 ID:SGTC_274|Compound:sirtinol|FD-Score:-2.95|P-value:3.48E-4 ID:SGTC_398|Compound:bronopol|FD-Score:2.65|P-value:8.31E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.55|P-value:1.34E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:-2.74|P-value:8.07E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.63|P-value:9.01E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.31|P-value:4.43E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:5.24|P-value:3.30E-10 ID:SGTC_781|Compound:4335-2806|FD-Score:2.75|P-value:5.51E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.22|P-value:3.22E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:2.85|P-value:3.69E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:2.61|P-value:9.65E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.96|P-value:3.36E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.56|P-value:1.29E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:2.68|P-value:7.46E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:2.77|P-value:5.06E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.32|P-value:4.28E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:-2.75|P-value:7.93E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.01|P-value:1.79E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.13|P-value:1.06E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:2.74|P-value:5.72E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:5.66|P-value:1.36E-11 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.17|P-value:1.34E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.86|P-value:3.54E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.94|P-value:2.45E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-2.70|P-value:9.79E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.87|P-value:2.41E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.08|P-value:2.02E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.84|P-value:5.56E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.88|P-value:4.36E-9 ID:SGTC_1654|Compound:st012436|FD-Score:-3.37|P-value:5.27E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.30|P-value:1.95E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-4.06|P-value:1.34E-6 ID:SGTC_1790|Compound:st045711|FD-Score:-2.73|P-value:8.69E-4 ID:SGTC_1791|Compound:st048313|FD-Score:2.99|P-value:1.94E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.46|P-value:2.13E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.76|P-value:1.00E-8 ID:SGTC_2068|Compound:5226020|FD-Score:4.96|P-value:2.53E-9 ID:SGTC_2165|Compound:5727197|FD-Score:3.80|P-value:3.66E-6 ID:SGTC_2239|Compound:6685329|FD-Score:2.64|P-value:8.69E-4 ID:SGTC_2276|Compound:7947513|FD-Score:2.96|P-value:2.27E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-4.92|P-value:6.45E-9 ID:SGTC_2318|Compound:6029776|FD-Score:-2.83|P-value:5.75E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.37|P-value:3.31E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.10|P-value:1.20E-4 ID:SGTC_2340|Compound:7987427|FD-Score:7.11|P-value:3.46E-17 ID:SGTC_2344|Compound:7990960|FD-Score:-4.35|P-value:2.45E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.74|P-value:7.78E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.32|P-value:3.53E-10 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.16|P-value:1.35E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.71|P-value:5.98E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.37|P-value:5.11E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.03|P-value:1.62E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.09|P-value:1.24E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.17|P-value:1.96E-13 ID:SGTC_2484|Compound:5809818|FD-Score:-3.22|P-value:1.03E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:2.77|P-value:5.07E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-2.77|P-value:7.17E-4 ID:SGTC_2671|Compound:danthron|FD-Score:2.81|P-value:4.29E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.28|P-value:2.16E-7 ID:SGTC_2691|Compound:st077356|FD-Score:3.20|P-value:7.46E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.41|P-value:4.31E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-5.93|P-value:3.06E-12 ID:SGTC_2875|Compound:9039966|FD-Score:-3.27|P-value:8.13E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.13|P-value:1.05E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-2.72|P-value:8.82E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.63|P-value:8.88E-6 ID:SGTC_3220|Compound:9131269|FD-Score:2.80|P-value:4.53E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.10|P-value:6.61E-7 ID:SGTC_3331|Compound:9141060|FD-Score:-2.94|P-value:3.59E-4

Top fitness defect scores for YPL074W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2340 7987427 7.11 183.4 µM 3.46E-17 3 5.96E-13
2 SGTC_234 nsc-17383 6.22 10.7 µM 1.27E-13 ERG2 10 2.44E-10
3 SGTC_2479 5617353 6.17 43.9 µM 1.96E-13 7 3.36E-10
4 SGTC_1254 0550-0035 5.66 264.0 µM 1.36E-11 4 7.53E-9
5 SGTC_757 1066-0008 5.24 322.0 µM 3.30E-10 Golgi 7 7.82E-8
6 SGTC_2068 5226020 4.96 147.0 µM 2.53E-9 12 3.48E-7
7 SGTC_1522 st012842 4.88 45.6 µM 4.36E-9 RNA pol III & RNase P/MRP 11 5.20E-7
8 SGTC_1968 st069590 4.76 43.6 µM 1.00E-8 7 9.58E-7
9 SGTC_1742 st038235 4.30 28.9 µM 1.95E-7 mitochondrial stress 103 8.47E-6
10 SGTC_2690 usnic acid 4.28 100.0 µM 2.16E-7 22 9.14E-6
11 SGTC_798 1287-0182 4.22 476.0 µM 3.22E-7 16 1.23E-5
12 SGTC_3305 9127027 4.10 53.8 µM 6.61E-7 13 2.08E-5
13 SGTC_1450 4112-4260 3.87 37.6 µM 2.41E-6 calcium & mitochondrial duress 30 5.39E-5
14 SGTC_2165 5727197 3.80 32.1 µM 3.66E-6 36 7.34E-5
15 SGTC_2415 st077333 3.71 57.7 µM 5.98E-6 60 1.05E-4
16 SGTC_3205 9113483 3.63 49.5 µM 8.88E-6 40 1.41E-4
17 SGTC_1045 1348-1485 3.56 165.0 µM 1.29E-5 50 1.86E-4
18 SGTC_402 epigallocatechin gallate 3.55 10.0 µM 1.34E-5 41 1.91E-4
19 SGTC_1956 st077085 3.46 54.0 µM 2.13E-5 33 2.69E-4
20 SGTC_2327 6189656 3.37 200.0 µM 3.31E-5 38 3.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.00E-13 YOL134C_d YOL134C_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
0.123 7.94E-13 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.123 8.33E-13 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.113 6.29E-11 YJR141W_p YJR141W_p het Essential protein of unknown function
0.110 1.54E-10 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.110 1.72E-10 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.102 3.08E-9 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.100 7.58E-9 YIR004W DJP1 hom Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
0.097 1.93E-8 YAL003W EFB1 het Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
0.096 2.89E-8 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.094 5.68E-8 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.091 1.15E-7 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.089 2.38E-7 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.088 3.36E-7 YJL144W YJL144W hom Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress
0.088 3.52E-7 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p