YPL075W / GCR1

Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL075W / GCR1

Click on Significant Values for Screen Details ID:SGTC_128|Compound:0906-2981|FD-Score:7.99|P-value:1.08E-16 ID:SGTC_144|Compound:4161-2749|FD-Score:4.04|P-value:1.63E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.66|P-value:8.24E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:6.56|P-value:7.44E-12 ID:SGTC_264|Compound:promethazine|FD-Score:4.34|P-value:3.92E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:3.40|P-value:2.32E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.02|P-value:9.25E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.40|P-value:2.32E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.99|P-value:2.20E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.09|P-value:7.71E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:5.11|P-value:7.13E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.20|P-value:4.93E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.78|P-value:4.28E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.82|P-value:3.59E-7 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.08|P-value:8.17E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.61|P-value:1.01E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.08|P-value:8.50E-8 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.18|P-value:5.21E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.36|P-value:2.73E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.25|P-value:4.00E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.78|P-value:5.05E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.89|P-value:3.04E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.25|P-value:6.74E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:3.32|P-value:3.12E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:-3.26|P-value:4.28E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-4.68|P-value:8.14E-7 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.11|P-value:7.21E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.27|P-value:2.94E-8 ID:SGTC_1717|Compound:st033143|FD-Score:3.04|P-value:8.57E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.90|P-value:2.96E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.42|P-value:2.13E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.52|P-value:1.43E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.06|P-value:8.18E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.27|P-value:4.13E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.95|P-value:2.35E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.97|P-value:2.20E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.28|P-value:5.84E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.26|P-value:3.88E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.07|P-value:7.85E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.84|P-value:3.15E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.28|P-value:5.32E-6 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.36|P-value:2.92E-4 ID:SGTC_2780|Compound:5215298|FD-Score:5.22|P-value:4.00E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-3.18|P-value:5.62E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-3.36|P-value:2.93E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.12|P-value:6.46E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.45|P-value:1.88E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-3.97|P-value:2.36E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-4.19|P-value:8.89E-6 ID:SGTC_3113|Compound:9123498|FD-Score:3.69|P-value:7.26E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.13|P-value:6.41E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.68|P-value:7.12E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-3.05|P-value:9.04E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:7.99|P-value:1.08E-16 ID:SGTC_144|Compound:4161-2749|FD-Score:4.04|P-value:1.63E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.66|P-value:8.24E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:6.56|P-value:7.44E-12 ID:SGTC_264|Compound:promethazine|FD-Score:4.34|P-value:3.92E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:3.40|P-value:2.32E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.02|P-value:9.25E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.40|P-value:2.32E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.99|P-value:2.20E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.09|P-value:7.71E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:5.11|P-value:7.13E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.20|P-value:4.93E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.78|P-value:4.28E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.82|P-value:3.59E-7 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.08|P-value:8.17E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.61|P-value:1.01E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.08|P-value:8.50E-8 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.18|P-value:5.21E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.36|P-value:2.73E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.25|P-value:4.00E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.78|P-value:5.05E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.89|P-value:3.04E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.25|P-value:6.74E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:3.32|P-value:3.12E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:-3.26|P-value:4.28E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-4.68|P-value:8.14E-7 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.11|P-value:7.21E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.27|P-value:2.94E-8 ID:SGTC_1717|Compound:st033143|FD-Score:3.04|P-value:8.57E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.90|P-value:2.96E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.42|P-value:2.13E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.52|P-value:1.43E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.06|P-value:8.18E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.27|P-value:4.13E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.95|P-value:2.35E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.97|P-value:2.20E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.28|P-value:5.84E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.26|P-value:3.88E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.07|P-value:7.85E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.84|P-value:3.15E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.28|P-value:5.32E-6 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.36|P-value:2.92E-4 ID:SGTC_2780|Compound:5215298|FD-Score:5.22|P-value:4.00E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-3.18|P-value:5.62E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-3.36|P-value:2.93E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.12|P-value:6.46E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.45|P-value:1.88E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-3.97|P-value:2.36E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-4.19|P-value:8.89E-6 ID:SGTC_3113|Compound:9123498|FD-Score:3.69|P-value:7.26E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.13|P-value:6.41E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.68|P-value:7.12E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-3.05|P-value:9.04E-4

Top fitness defect scores for YPL075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_128 0906-2981 7.99 13.4 µM 1.08E-16 1 6.90E-16 2.15
2 SGTC_219 mitoxanthrone 6.56 164.4 µM 7.44E-12 DNA intercalators 4 2.66E-11 0.12
3 SGTC_1597 7-benzyloxygramine 5.27 47.5 µM 2.94E-8 calcium & mitochondrial duress 41 6.82E-8 0.32
4 SGTC_2780 5215298 5.22 71.4 µM 4.00E-8 8 9.15E-8 0.24
5 SGTC_781 4335-2806 5.11 94.4 µM 7.13E-8 2 1.58E-7 1.17
6 SGTC_1170 0310-0127 5.08 64.8 µM 8.50E-8 4 1.87E-7 0.15
7 SGTC_2679 rapamycin 4.84 1.0 nM 3.15E-7 39 6.47E-7 0.00
8 SGTC_1112 tnp00069 4.82 1.2 µM 3.59E-7 2 7.32E-7 0.76
9 SGTC_1054 3429-0080 4.78 167.0 µM 4.28E-7 2 8.65E-7 0.09
10 SGTC_3186 9110464 4.68 49.5 µM 7.12E-7 RPP1 & pyrimidine depletion 1 1.40E-6 0.98
11 SGTC_264 promethazine 4.34 12.5 mM 3.92E-6 DNA intercalators 19 7.06E-6 0.23
12 SGTC_2697 mebhydrolin 4.28 72.4 µM 5.32E-6 NEO1 4 9.43E-6 0.09
13 SGTC_144 4161-2749 4.04 112.4 µM 1.63E-5 DNA intercalators 16 2.73E-5 0.01
14 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.97 63.6 µM 2.20E-5 10 3.62E-5 0.20
15 SGTC_2517 totarol 3.95 10.0 µM 2.35E-5 6 3.86E-5 0.44
16 SGTC_1844 rapamycin 3.90 4.0 nM 2.96E-5 53 4.81E-5 0.03
17 SGTC_1465 k213-0056 3.89 144.0 µM 3.04E-5 DNA intercalators 13 4.92E-5 0.15
18 SGTC_1293 1000-1278 3.78 195.0 µM 5.05E-5 8 7.97E-5 0.03
19 SGTC_3113 9123498 3.69 49.5 µM 7.26E-5 8 1.12E-4 0.07
20 SGTC_145 3737-0113 3.66 38.4 µM 8.24E-5 DNA intercalators 57 1.27E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 1.18E-43 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.219 1.22E-37 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.197 9.16E-31 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.170 4.55E-23 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.165 8.79E-22 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.162 3.69E-21 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.154 3.97E-19 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.145 3.05E-17 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.144 7.42E-17 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.139 6.11E-16 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.133 9.09E-15 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.132 1.62E-14 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.131 2.36E-14 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.128 1.23E-13 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.95E-13 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4