YPL079W / RPL21B

Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL079W / RPL21B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.23|P-value:7.65E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.15|P-value:6.25E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.14|P-value:7.67E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.63|P-value:1.01E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:4.92|P-value:2.58E-7 ID:SGTC_747|Compound:3448-8087|FD-Score:3.42|P-value:2.30E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.73|P-value:6.67E-7 ID:SGTC_753|Compound:1322-0200|FD-Score:3.91|P-value:3.24E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.37|P-value:2.85E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:5.02|P-value:1.46E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.07|P-value:1.56E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:5.06|P-value:1.18E-7 ID:SGTC_977|Compound:1348-1378|FD-Score:3.50|P-value:1.72E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:5.35|P-value:2.39E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.13|P-value:6.82E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.18|P-value:6.82E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-5.63|P-value:6.07E-9 ID:SGTC_1137|Compound:ixabepilone|FD-Score:8.91|P-value:5.48E-20 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.34|P-value:2.54E-8 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.12|P-value:6.85E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.52|P-value:1.59E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.21|P-value:6.11E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.69|P-value:8.09E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.70|P-value:7.61E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.15|P-value:6.26E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.99|P-value:2.25E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.00|P-value:2.17E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.12|P-value:1.26E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.50|P-value:1.70E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-5.09|P-value:1.36E-7 ID:SGTC_1936|Compound:st074407|FD-Score:4.28|P-value:6.06E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.95|P-value:3.37E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.25|P-value:4.37E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.84|P-value:5.36E-5 ID:SGTC_2105|Compound:5350118|FD-Score:3.22|P-value:4.80E-4 ID:SGTC_2109|Compound:5483026|FD-Score:10.20|P-value:9.12E-26 ID:SGTC_2114|Compound:5491910|FD-Score:-3.85|P-value:5.15E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.78|P-value:5.45E-5 ID:SGTC_2167|Compound:5876490|FD-Score:5.49|P-value:1.02E-8 ID:SGTC_2338|Compound:7999974|FD-Score:-3.31|P-value:4.21E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.88|P-value:4.56E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.14|P-value:7.81E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-4.06|P-value:2.12E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.68|P-value:1.04E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.70|P-value:7.54E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.23|P-value:4.70E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.49|P-value:2.19E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-3.68|P-value:1.03E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.18|P-value:5.70E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.64|P-value:1.08E-6 ID:SGTC_2913|Compound:7966556|FD-Score:5.40|P-value:1.73E-8 ID:SGTC_2933|Compound:9026794|FD-Score:3.21|P-value:4.99E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.95|P-value:2.72E-5 ID:SGTC_2947|Compound:9072639|FD-Score:4.67|P-value:9.21E-7 ID:SGTC_3002|Compound:9075603|FD-Score:4.83|P-value:3.96E-7 ID:SGTC_3004|Compound:9076122|FD-Score:3.23|P-value:4.79E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.07|P-value:1.62E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.41|P-value:2.90E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.19|P-value:5.38E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.07|P-value:1.59E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.14|P-value:6.46E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.73|P-value:6.79E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.48|P-value:2.24E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.40|P-value:3.08E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.42|P-value:2.80E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.23|P-value:7.65E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.15|P-value:6.25E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.14|P-value:7.67E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.63|P-value:1.01E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:4.92|P-value:2.58E-7 ID:SGTC_747|Compound:3448-8087|FD-Score:3.42|P-value:2.30E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.73|P-value:6.67E-7 ID:SGTC_753|Compound:1322-0200|FD-Score:3.91|P-value:3.24E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.37|P-value:2.85E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:5.02|P-value:1.46E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.07|P-value:1.56E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:5.06|P-value:1.18E-7 ID:SGTC_977|Compound:1348-1378|FD-Score:3.50|P-value:1.72E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:5.35|P-value:2.39E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.13|P-value:6.82E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.18|P-value:6.82E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-5.63|P-value:6.07E-9 ID:SGTC_1137|Compound:ixabepilone|FD-Score:8.91|P-value:5.48E-20 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.34|P-value:2.54E-8 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.12|P-value:6.85E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.52|P-value:1.59E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.21|P-value:6.11E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.69|P-value:8.09E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.70|P-value:7.61E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.15|P-value:6.26E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.99|P-value:2.25E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.00|P-value:2.17E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.12|P-value:1.26E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.50|P-value:1.70E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-5.09|P-value:1.36E-7 ID:SGTC_1936|Compound:st074407|FD-Score:4.28|P-value:6.06E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.95|P-value:3.37E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.25|P-value:4.37E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.84|P-value:5.36E-5 ID:SGTC_2105|Compound:5350118|FD-Score:3.22|P-value:4.80E-4 ID:SGTC_2109|Compound:5483026|FD-Score:10.20|P-value:9.12E-26 ID:SGTC_2114|Compound:5491910|FD-Score:-3.85|P-value:5.15E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.78|P-value:5.45E-5 ID:SGTC_2167|Compound:5876490|FD-Score:5.49|P-value:1.02E-8 ID:SGTC_2338|Compound:7999974|FD-Score:-3.31|P-value:4.21E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.88|P-value:4.56E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.14|P-value:7.81E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-4.06|P-value:2.12E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.68|P-value:1.04E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.70|P-value:7.54E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.23|P-value:4.70E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.49|P-value:2.19E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-3.68|P-value:1.03E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.18|P-value:5.70E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.64|P-value:1.08E-6 ID:SGTC_2913|Compound:7966556|FD-Score:5.40|P-value:1.73E-8 ID:SGTC_2933|Compound:9026794|FD-Score:3.21|P-value:4.99E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.95|P-value:2.72E-5 ID:SGTC_2947|Compound:9072639|FD-Score:4.67|P-value:9.21E-7 ID:SGTC_3002|Compound:9075603|FD-Score:4.83|P-value:3.96E-7 ID:SGTC_3004|Compound:9076122|FD-Score:3.23|P-value:4.79E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.07|P-value:1.62E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.41|P-value:2.90E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.19|P-value:5.38E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.07|P-value:1.59E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.14|P-value:6.46E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.73|P-value:6.79E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.48|P-value:2.24E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.40|P-value:3.08E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.42|P-value:2.80E-4

Top fitness defect scores for YPL079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2109 5483026 10.20 200.0 µM 9.12E-26 RSC complex & mRNA processing 1 6.56E-25
2 SGTC_1137 ixabepilone 8.91 100.0 µM 5.48E-20 1 2.53E-19
3 SGTC_2167 5876490 5.49 200.0 µM 1.02E-8 8 1.96E-8
4 SGTC_2913 7966556 5.40 36.6 µM 1.73E-8 60S ribosome export 2 3.26E-8
5 SGTC_979 1426-2828 5.35 121.0 µM 2.39E-8 6 4.45E-8
6 SGTC_1369 1866-0067 5.34 208.0 µM 2.54E-8 RPP1 & pyrimidine depletion 16 4.72E-8
7 SGTC_974 1326-0144 5.06 138.0 µM 1.18E-7 ERG2 20 2.08E-7
8 SGTC_873 0591-4978 5.02 488.0 µM 1.46E-7 7 2.56E-7
9 SGTC_538 2922-0838 4.92 53.3 µM 2.58E-7 Golgi 14 4.43E-7
10 SGTC_3002 9075603 4.83 71.4 µM 3.96E-7 7 6.69E-7
11 SGTC_751 0833-0568 4.73 350.0 µM 6.67E-7 9 1.11E-6
12 SGTC_2947 9072639 4.67 7.7 µM 9.21E-7 tubulin folding & SWR complex 25 1.51E-6
13 SGTC_2907 7721985 4.64 69.9 µM 1.08E-6 8 1.76E-6
14 SGTC_2760 etidronate 4.49 98.0 µM 2.19E-6 15 3.48E-6
15 SGTC_1936 st074407 4.28 74.3 µM 6.06E-6 DNA damage response 25 9.30E-6
16 SGTC_118 0083-0097 4.23 135.3 µM 7.65E-6 translation 107 1.16E-5
17 SGTC_1916 st067606 4.12 49.2 µM 1.26E-5 32 1.88E-5
18 SGTC_961 1252-1571 4.07 372.0 µM 1.56E-5 28 2.31E-5
19 SGTC_3052 9092717 4.07 49.5 µM 1.59E-5 24 2.36E-5
20 SGTC_3033 9090887 4.07 49.5 µM 1.62E-5 fatty acid desaturase (OLE1) 22 2.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.63E-11 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.107 5.71E-10 YEL057C_p YEL057C_p hom Protein of unknown function involved in telomere maintenance; target of UME6 regulation
0.092 8.28E-8 YGL127C SOH1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
0.091 1.24E-7 YGL053W PRM8 hom Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
0.091 1.45E-7 YGR124W ASN2 hom Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication
0.085 7.92E-7 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.085 8.06E-7 YMR194W RPL36A hom Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication
0.084 9.65E-7 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.084 9.88E-7 YFR018C_p YFR018C_p hom Putative protein of unknown function
0.084 1.05E-6 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.079 4.51E-6 YCL033C MXR2 hom Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.078 6.27E-6 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.078 6.68E-6 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.077 8.38E-6 YDR207C UME6 hom Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
0.077 8.84E-6 YJR125C ENT3 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p