YPL080C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL080C / YPL080C

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:6.72|P-value:7.03E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:7.43|P-value:1.18E-11 ID:SGTC_76|Compound:0433-0009|FD-Score:7.94|P-value:5.18E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.75|P-value:8.86E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:6.37|P-value:4.62E-9 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.73|P-value:9.45E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.84|P-value:2.09E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.95|P-value:4.87E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.76|P-value:2.74E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.53|P-value:5.65E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.60|P-value:4.52E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.74|P-value:9.25E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:5.05|P-value:2.19E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.88|P-value:1.79E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.41|P-value:8.02E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.72|P-value:9.93E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.34|P-value:9.97E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.36|P-value:3.35E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.69|P-value:3.42E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.36|P-value:9.23E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.61|P-value:1.33E-5 ID:SGTC_1684|Compound:st024538|FD-Score:5.88|P-value:5.26E-8 ID:SGTC_1759|Compound:st043059|FD-Score:3.46|P-value:6.83E-4 ID:SGTC_1778|Compound:st046819|FD-Score:5.75|P-value:9.49E-8 ID:SGTC_1941|Compound:st076221|FD-Score:-3.76|P-value:8.59E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.64|P-value:3.94E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.15|P-value:7.13E-5 ID:SGTC_2023|Compound:5144124|FD-Score:5.14|P-value:1.53E-6 ID:SGTC_2105|Compound:5350118|FD-Score:3.66|P-value:3.74E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.38|P-value:3.14E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.62|P-value:4.27E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.10|P-value:1.80E-6 ID:SGTC_2966|Compound:9084041|FD-Score:4.19|P-value:6.18E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-5.82|P-value:3.97E-7 ID:SGTC_2987|Compound:9018338|FD-Score:6.69|P-value:8.25E-10 ID:SGTC_3055|Compound:9094636|FD-Score:6.48|P-value:2.48E-9 ID:SGTC_3056|Compound:9094900|FD-Score:4.07|P-value:9.64E-5 ID:SGTC_3058|Compound:9093861|FD-Score:9.41|P-value:1.93E-17 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.18|P-value:2.32E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:-4.84|P-value:2.23E-5 ID:SGTC_3097|Compound:9117246|FD-Score:5.16|P-value:1.37E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-3.82|P-value:7.21E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.75|P-value:8.88E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.38|P-value:1.21E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.64|P-value:3.92E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-5.15|P-value:6.73E-6 ID:SGTC_3274|Compound:9138298|FD-Score:-4.36|P-value:1.26E-4 ID:SGTC_3275|Compound:9138069|FD-Score:5.15|P-value:1.47E-6 ID:SGTC_3280|Compound:9140961|FD-Score:3.74|P-value:2.91E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.56|P-value:5.11E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-5.97|P-value:2.02E-7 ID:SGTC_3320|Compound:9137005|FD-Score:-3.74|P-value:9.30E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:6.72|P-value:7.03E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:7.43|P-value:1.18E-11 ID:SGTC_76|Compound:0433-0009|FD-Score:7.94|P-value:5.18E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.75|P-value:8.86E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:6.37|P-value:4.62E-9 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.73|P-value:9.45E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.84|P-value:2.09E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.95|P-value:4.87E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.76|P-value:2.74E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.53|P-value:5.65E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.60|P-value:4.52E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.74|P-value:9.25E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:5.05|P-value:2.19E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.88|P-value:1.79E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.41|P-value:8.02E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.72|P-value:9.93E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.34|P-value:9.97E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.36|P-value:3.35E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.69|P-value:3.42E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.36|P-value:9.23E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.61|P-value:1.33E-5 ID:SGTC_1684|Compound:st024538|FD-Score:5.88|P-value:5.26E-8 ID:SGTC_1759|Compound:st043059|FD-Score:3.46|P-value:6.83E-4 ID:SGTC_1778|Compound:st046819|FD-Score:5.75|P-value:9.49E-8 ID:SGTC_1941|Compound:st076221|FD-Score:-3.76|P-value:8.59E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.64|P-value:3.94E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.15|P-value:7.13E-5 ID:SGTC_2023|Compound:5144124|FD-Score:5.14|P-value:1.53E-6 ID:SGTC_2105|Compound:5350118|FD-Score:3.66|P-value:3.74E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.38|P-value:3.14E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.62|P-value:4.27E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.10|P-value:1.80E-6 ID:SGTC_2966|Compound:9084041|FD-Score:4.19|P-value:6.18E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-5.82|P-value:3.97E-7 ID:SGTC_2987|Compound:9018338|FD-Score:6.69|P-value:8.25E-10 ID:SGTC_3055|Compound:9094636|FD-Score:6.48|P-value:2.48E-9 ID:SGTC_3056|Compound:9094900|FD-Score:4.07|P-value:9.64E-5 ID:SGTC_3058|Compound:9093861|FD-Score:9.41|P-value:1.93E-17 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.18|P-value:2.32E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:-4.84|P-value:2.23E-5 ID:SGTC_3097|Compound:9117246|FD-Score:5.16|P-value:1.37E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-3.82|P-value:7.21E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.75|P-value:8.88E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.38|P-value:1.21E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.64|P-value:3.92E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-5.15|P-value:6.73E-6 ID:SGTC_3274|Compound:9138298|FD-Score:-4.36|P-value:1.26E-4 ID:SGTC_3275|Compound:9138069|FD-Score:5.15|P-value:1.47E-6 ID:SGTC_3280|Compound:9140961|FD-Score:3.74|P-value:2.91E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.56|P-value:5.11E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-5.97|P-value:2.02E-7 ID:SGTC_3320|Compound:9137005|FD-Score:-3.74|P-value:9.30E-4

Top fitness defect scores for YPL080C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3058 9093861 9.41 49.5 µM 1.93E-17 1 2.37E-21
2 SGTC_76 0433-0009 7.94 400.3 µM 5.18E-13 1 1.00E-15
3 SGTC_74 000s-0487 7.43 160.3 µM 1.18E-11 3 5.25E-14
4 SGTC_69 0096-0274 6.72 206.7 µM 7.03E-10 mitochondrial processes 7 9.11E-12
5 SGTC_2987 9018338 6.69 71.4 µM 8.25E-10 RPP1 & pyrimidine depletion 2 1.11E-11
6 SGTC_3055 9094636 6.48 49.5 µM 2.48E-9 2 4.45E-11
7 SGTC_262 fenpropimorph 6.37 62.5 µM 4.62E-9 ergosterol depletion effects on membrane 10 9.75E-11
8 SGTC_1684 st024538 5.88 14.6 µM 5.26E-8 1 2.07E-9
9 SGTC_1778 st046819 5.75 58.9 µM 9.49E-8 8 4.34E-9
10 SGTC_3097 9117246 5.16 49.5 µM 1.37E-6 1 1.23E-7
11 SGTC_3275 9138069 5.15 49.5 µM 1.47E-6 2 1.33E-7
12 SGTC_2023 5144124 5.14 124.0 µM 1.53E-6 8 1.40E-7
13 SGTC_2592 piperlongumine 5.10 83.3 µM 1.80E-6 TSC3-RPN4 12 1.72E-7
14 SGTC_639 0833-0042 5.05 114.0 µM 2.19E-6 20 2.19E-7
15 SGTC_1468 k284-1086 4.61 134.0 µM 1.33E-5 DNA intercalators 16 2.06E-6
16 SGTC_2410 aloe-emodin-8-o-glycoside 4.38 46.3 µM 3.14E-5 mitochondrial processes 18 5.98E-6
17 SGTC_1038 k292-0204 4.36 154.0 µM 3.35E-5 8 6.49E-6
18 SGTC_2966 9084041 4.19 48.0 µM 6.18E-5 26 1.39E-5
19 SGTC_2017 5132927 4.15 60.6 µM 7.13E-5 26 1.65E-5
20 SGTC_3056 9094900 4.07 49.5 µM 9.64E-5 20 2.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.28E-7 YHR183W GND1 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication
0.083 1.59E-6 YGL069C_d YGL069C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
0.082 1.99E-6 YDL026W_d YDL026W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.077 8.32E-6 YPR049C ATG11 hom Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)
0.076 1.09E-5 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.075 1.30E-5 YLR183C TOS4 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication
0.074 1.70E-5 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.074 1.69E-5 YGR192C TDH3 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication
0.073 2.49E-5 YNL207W RIO2 het Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
0.071 3.66E-5 YPL103C FMP30 hom Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D
0.068 7.63E-5 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.068 9.03E-5 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.066 1.24E-4 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.066 1.22E-4 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.065 1.51E-4 YGL063W PUS2 hom Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification