YPL081W / RPS9A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL081W / RPS9A

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:4.14|P-value:1.66E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:3.21|P-value:6.47E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:4.12|P-value:1.81E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:3.86|P-value:5.38E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.42|P-value:4.00E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.34|P-value:3.67E-4 ID:SGTC_512|Compound:prima-1|FD-Score:4.92|P-value:3.99E-7 ID:SGTC_718|Compound:1130-0073|FD-Score:3.09|P-value:9.63E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.78|P-value:7.44E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.17|P-value:7.34E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.28|P-value:5.00E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.45|P-value:2.68E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.26|P-value:5.39E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:7.42|P-value:4.51E-14 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.67|P-value:1.03E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.64|P-value:1.31E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.48|P-value:2.38E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.19|P-value:6.90E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.76|P-value:7.96E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.23|P-value:6.00E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.74|P-value:8.68E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.19|P-value:6.92E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.44|P-value:2.76E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.33|P-value:6.87E-6 ID:SGTC_1807|Compound:st050092|FD-Score:3.68|P-value:1.13E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.43|P-value:2.66E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.54|P-value:1.93E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.44|P-value:2.79E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.03|P-value:2.62E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.79|P-value:7.06E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.11|P-value:9.12E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.65|P-value:1.24E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.25|P-value:5.62E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.37|P-value:3.40E-8 ID:SGTC_3137|Compound:9097352|FD-Score:3.24|P-value:5.76E-4 ID:SGTC_3301|Compound:9125354|FD-Score:5.72|P-value:4.49E-9 ID:SGTC_17|Compound:0960-0276|FD-Score:4.14|P-value:1.66E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:3.21|P-value:6.47E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:4.12|P-value:1.81E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:3.86|P-value:5.38E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.42|P-value:4.00E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.34|P-value:3.67E-4 ID:SGTC_512|Compound:prima-1|FD-Score:4.92|P-value:3.99E-7 ID:SGTC_718|Compound:1130-0073|FD-Score:3.09|P-value:9.63E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.78|P-value:7.44E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.17|P-value:7.34E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.28|P-value:5.00E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.45|P-value:2.68E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.26|P-value:5.39E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:7.42|P-value:4.51E-14 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.67|P-value:1.03E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.64|P-value:1.31E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.48|P-value:2.38E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.19|P-value:6.90E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.76|P-value:7.96E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.23|P-value:6.00E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.74|P-value:8.68E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.19|P-value:6.92E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.44|P-value:2.76E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.33|P-value:6.87E-6 ID:SGTC_1807|Compound:st050092|FD-Score:3.68|P-value:1.13E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.43|P-value:2.66E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.54|P-value:1.93E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.44|P-value:2.79E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.03|P-value:2.62E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.79|P-value:7.06E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.11|P-value:9.12E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.65|P-value:1.24E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.25|P-value:5.62E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.37|P-value:3.40E-8 ID:SGTC_3137|Compound:9097352|FD-Score:3.24|P-value:5.76E-4 ID:SGTC_3301|Compound:9125354|FD-Score:5.72|P-value:4.49E-9

Top fitness defect scores for YPL081W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1045 1348-1485 7.42 165.0 µM 4.51E-14 1 5.98E-14
2 SGTC_3301 9125354 5.72 19.8 µM 4.49E-9 4 5.21E-9
3 SGTC_2601 securinine 5.37 100.0 µM 3.40E-8 9 3.86E-8
4 SGTC_512 prima-1 4.92 270.0 µM 3.99E-7 DNA intercalators 10 4.42E-7
5 SGTC_1726 st035556 4.33 14.6 µM 6.87E-6 27 7.38E-6
6 SGTC_17 0960-0276 4.14 49.8 µM 1.66E-5 27 1.77E-5
7 SGTC_22 0964-0034 4.12 14.5 µM 1.81E-5 unfolded protein response 43 1.93E-5
8 SGTC_1945 st075991 4.03 56.6 µM 2.62E-5 60S ribosome export 15 2.78E-5
9 SGTC_23 0213-0011 3.86 40.0 µM 5.38E-5 copper-dependent oxidative stress 29 5.66E-5
10 SGTC_1963 st076565 3.79 50.3 µM 7.06E-5 14 7.41E-5
11 SGTC_728 3030-5151 3.78 22.5 µM 7.44E-5 19 7.80E-5
12 SGTC_1366 1683-0113 3.76 21.9 µM 7.96E-5 15 8.35E-5
13 SGTC_1530 rhein 3.74 70.4 µM 8.68E-5 24 9.10E-5
14 SGTC_1807 st050092 3.68 58.9 µM 1.13E-4 60S ribosome export 19 1.18E-4
15 SGTC_1673 st016611 3.67 27.3 µM 1.14E-4 57 1.19E-4
16 SGTC_2466 5983409 3.65 37.1 µM 1.24E-4 27 1.29E-4
17 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 3.64 15.5 µM 1.31E-4 36 1.37E-4
18 SGTC_1912 st060209 3.54 90.8 µM 1.93E-4 47 2.01E-4
19 SGTC_1135 dihydrocapsaicin 3.48 536.7 nM 2.38E-4 52 2.47E-4
20 SGTC_914 3820-6779 3.45 408.0 µM 2.68E-4 38 2.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.81E-10 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.102 3.81E-9 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.093 6.41E-8 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.093 6.83E-8 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.091 1.20E-7 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.091 1.26E-7 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.091 1.30E-7 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.090 1.84E-7 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.089 2.33E-7 YHR182W YHR182W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.084 9.99E-7 YMR182C RGM1 hom Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.082 2.24E-6 YCL025C AGP1 hom Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication
0.080 3.39E-6 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.080 3.91E-6 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.079 4.06E-6 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.077 8.42E-6 YPR007C REC8 hom Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p