YPL083C / SEN54

Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL083C / SEN54

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:3.36|P-value:2.19E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.15|P-value:3.64E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.43|P-value:1.21E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.00|P-value:6.48E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.18|P-value:4.39E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.48|P-value:1.27E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.40|P-value:1.93E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.83|P-value:2.92E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.19|P-value:4.14E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:2.98|P-value:9.11E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.07|P-value:9.80E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.29|P-value:2.15E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:5.36|P-value:8.75E-9 ID:SGTC_1635|Compound:st007035|FD-Score:-3.38|P-value:1.50E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.25|P-value:3.33E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.99|P-value:1.43E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.59|P-value:6.94E-7 ID:SGTC_1848|Compound:st056003|FD-Score:3.08|P-value:6.27E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-4.84|P-value:1.17E-7 ID:SGTC_1862|Compound:st057513|FD-Score:4.35|P-value:2.43E-6 ID:SGTC_2020|Compound:4017018|FD-Score:4.05|P-value:1.06E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.41|P-value:1.77E-4 ID:SGTC_2102|Compound:5377816|FD-Score:-2.91|P-value:9.13E-4 ID:SGTC_2158|Compound:5657123|FD-Score:-3.01|P-value:6.29E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.79|P-value:3.50E-5 ID:SGTC_2269|Compound:7935389|FD-Score:-2.92|P-value:8.69E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-2.90|P-value:9.48E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-5.42|P-value:3.71E-9 ID:SGTC_2284|Compound:7945075|FD-Score:-2.89|P-value:9.53E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:2.97|P-value:9.32E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.15|P-value:4.91E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.89|P-value:1.63E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.13|P-value:4.00E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.35|P-value:2.27E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.13|P-value:5.27E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.05|P-value:7.12E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.60|P-value:5.83E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.51|P-value:1.18E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-3.95|P-value:1.18E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.52|P-value:1.14E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.36|P-value:2.19E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.15|P-value:3.64E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.43|P-value:1.21E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.00|P-value:6.48E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.18|P-value:4.39E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.48|P-value:1.27E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.40|P-value:1.93E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.83|P-value:2.92E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.19|P-value:4.14E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:2.98|P-value:9.11E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.07|P-value:9.80E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.29|P-value:2.15E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:5.36|P-value:8.75E-9 ID:SGTC_1635|Compound:st007035|FD-Score:-3.38|P-value:1.50E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.25|P-value:3.33E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.99|P-value:1.43E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.59|P-value:6.94E-7 ID:SGTC_1848|Compound:st056003|FD-Score:3.08|P-value:6.27E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-4.84|P-value:1.17E-7 ID:SGTC_1862|Compound:st057513|FD-Score:4.35|P-value:2.43E-6 ID:SGTC_2020|Compound:4017018|FD-Score:4.05|P-value:1.06E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.41|P-value:1.77E-4 ID:SGTC_2102|Compound:5377816|FD-Score:-2.91|P-value:9.13E-4 ID:SGTC_2158|Compound:5657123|FD-Score:-3.01|P-value:6.29E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.79|P-value:3.50E-5 ID:SGTC_2269|Compound:7935389|FD-Score:-2.92|P-value:8.69E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-2.90|P-value:9.48E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-5.42|P-value:3.71E-9 ID:SGTC_2284|Compound:7945075|FD-Score:-2.89|P-value:9.53E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:2.97|P-value:9.32E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.15|P-value:4.91E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.89|P-value:1.63E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.13|P-value:4.00E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.35|P-value:2.27E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.13|P-value:5.27E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.05|P-value:7.12E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.60|P-value:5.83E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.51|P-value:1.18E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-3.95|P-value:1.18E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.52|P-value:1.14E-4

Top fitness defect scores for YPL083C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1575 cyproterone acetate 5.36 48.0 µM 8.75E-9 2 4.22E-8 0.91
2 SGTC_1823 3-hydroxy-2-naphthoic acid 4.59 106.0 µM 6.94E-7 1 2.17E-6 0.51
3 SGTC_1124 fisetin 4.48 1.2 µM 1.27E-6 9 3.75E-6 0.32
4 SGTC_1127 asiatic acid 4.40 681.4 nM 1.93E-6 5 5.46E-6 0.09
5 SGTC_1862 st057513 4.35 3.8 µM 2.43E-6 3 6.74E-6 0.12
6 SGTC_1513 0337-0559 4.07 19.0 µM 9.80E-6 6 2.37E-5 0.14
7 SGTC_2020 4017018 4.05 200.0 µM 1.06E-5 7 2.55E-5 0.11
8 SGTC_1714 st033236 3.99 13.6 µM 1.43E-5 7 3.34E-5 0.15
9 SGTC_1266 0828-0227 3.83 32.9 µM 2.92E-5 14 6.36E-5 0.29
10 SGTC_2160 5660466 3.79 132.9 µM 3.50E-5 60S ribosome export 17 7.50E-5 0.15
11 SGTC_3341 9147222 3.52 25.9 µM 1.14E-4 RNA processing & uracil transport 16 2.19E-4 0.10
12 SGTC_3234 9132280 3.51 49.5 µM 1.18E-4 7 2.26E-4 0.20
13 SGTC_2021 4019055 3.41 173.0 µM 1.77E-4 endomembrane recycling 45 3.25E-4 0.03
14 SGTC_91 0417-1751 3.36 58.4 µM 2.19E-4 Golgi 14 3.94E-4 0.08
15 SGTC_2758 dehydroepiandrosterone 3.35 69.3 µM 2.27E-4 15 4.08E-4 0.01
16 SGTC_1658 st012944 3.25 20.0 µM 3.33E-4 iron homeostasis 14 5.77E-4 0.08
17 SGTC_1372 2752-0194 3.19 270.0 µM 4.14E-4 7 7.03E-4 0.05
18 SGTC_699 0375-0592 3.18 111.0 µM 4.39E-4 iron homeostasis 8 7.41E-4 0.01
19 SGTC_2502 avocadyne acetate 3.15 18.6 µM 4.91E-4 12 8.21E-4 0.04
20 SGTC_2908 7930301 3.13 100.0 µM 5.27E-4 15 8.75E-4 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.92E-14 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.108 3.24E-10 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.094 4.92E-8 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.092 8.50E-8 YKR005C_p YKR005C_p hom Putative protein of unknown function
0.092 1.04E-7 YBR045C GIP1 hom Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
0.088 3.06E-7 YPL176C TRE1 hom Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication
0.086 5.80E-7 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.084 1.10E-6 YNL296W_d YNL296W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog
0.081 2.53E-6 YOR367W SCP1 hom Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
0.081 2.67E-6 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.88E-6 YMR084W_p YMR084W_p hom Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.080 3.62E-6 YFR018C_p YFR018C_p hom Putative protein of unknown function
0.080 3.83E-6 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.080 4.00E-6 YDR482C CWC21 hom Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p
0.076 9.34E-6 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase