YPL085W / SEC16

COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL085W / SEC16

Click on Significant Values for Screen Details ID:SGTC_114|Compound:0364-0001|FD-Score:2.93|P-value:7.25E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:2.96|P-value:6.38E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.40|P-value:1.09E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.05|P-value:5.07E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:3.96|P-value:8.07E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:-2.84|P-value:9.92E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.05|P-value:4.41E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.54|P-value:7.79E-10 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.47|P-value:7.97E-5 ID:SGTC_489|Compound:paxilline|FD-Score:-2.91|P-value:7.50E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.54|P-value:5.78E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.23|P-value:2.21E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.25|P-value:1.99E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:2.88|P-value:8.45E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.17|P-value:2.79E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.84|P-value:9.83E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-6.68|P-value:1.73E-13 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.01|P-value:5.10E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:8.77|P-value:6.12E-22 ID:SGTC_916|Compound:4466-0038|FD-Score:3.14|P-value:3.18E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.53|P-value:6.20E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:2.87|P-value:9.03E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.54|P-value:5.81E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:2.99|P-value:5.67E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-2.84|P-value:9.88E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.44|P-value:8.67E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.06|P-value:4.27E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.93|P-value:7.02E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.10|P-value:3.64E-4 ID:SGTC_1626|Compound:st003712|FD-Score:2.87|P-value:8.85E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.06|P-value:4.27E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.70|P-value:1.54E-7 ID:SGTC_1713|Compound:st033146|FD-Score:-3.94|P-value:8.70E-6 ID:SGTC_1714|Compound:st033236|FD-Score:-3.42|P-value:9.70E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-4.11|P-value:3.72E-6 ID:SGTC_1812|Compound:st052057|FD-Score:-2.98|P-value:5.86E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.72|P-value:2.47E-5 ID:SGTC_2032|Compound:5185112|FD-Score:3.64|P-value:3.62E-5 ID:SGTC_2036|Compound:5160441|FD-Score:8.23|P-value:1.54E-19 ID:SGTC_2149|Compound:5554786|FD-Score:3.40|P-value:1.05E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.10|P-value:3.65E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.36|P-value:1.29E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.36|P-value:1.27E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.32|P-value:1.51E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.00|P-value:5.54E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.92|P-value:7.31E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.94|P-value:8.98E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.26|P-value:1.70E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.20|P-value:2.46E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.20|P-value:2.52E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.03|P-value:4.77E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.35|P-value:1.29E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.42|P-value:7.36E-7 ID:SGTC_2986|Compound:9022445|FD-Score:3.85|P-value:1.40E-5 ID:SGTC_3087|Compound:9117406|FD-Score:3.06|P-value:4.37E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.89|P-value:1.11E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-4.53|P-value:3.96E-7 ID:SGTC_3186|Compound:9110464|FD-Score:3.24|P-value:2.06E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.21|P-value:2.22E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-4.62|P-value:2.41E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:2.93|P-value:7.25E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:2.96|P-value:6.38E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.40|P-value:1.09E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.05|P-value:5.07E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:3.96|P-value:8.07E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:-2.84|P-value:9.92E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.05|P-value:4.41E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.54|P-value:7.79E-10 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.47|P-value:7.97E-5 ID:SGTC_489|Compound:paxilline|FD-Score:-2.91|P-value:7.50E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.54|P-value:5.78E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.23|P-value:2.21E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.25|P-value:1.99E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:2.88|P-value:8.45E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.17|P-value:2.79E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.84|P-value:9.83E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-6.68|P-value:1.73E-13 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.01|P-value:5.10E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:8.77|P-value:6.12E-22 ID:SGTC_916|Compound:4466-0038|FD-Score:3.14|P-value:3.18E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.53|P-value:6.20E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:2.87|P-value:9.03E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.54|P-value:5.81E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:2.99|P-value:5.67E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-2.84|P-value:9.88E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.44|P-value:8.67E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.06|P-value:4.27E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.93|P-value:7.02E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.10|P-value:3.64E-4 ID:SGTC_1626|Compound:st003712|FD-Score:2.87|P-value:8.85E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.06|P-value:4.27E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.70|P-value:1.54E-7 ID:SGTC_1713|Compound:st033146|FD-Score:-3.94|P-value:8.70E-6 ID:SGTC_1714|Compound:st033236|FD-Score:-3.42|P-value:9.70E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-4.11|P-value:3.72E-6 ID:SGTC_1812|Compound:st052057|FD-Score:-2.98|P-value:5.86E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.72|P-value:2.47E-5 ID:SGTC_2032|Compound:5185112|FD-Score:3.64|P-value:3.62E-5 ID:SGTC_2036|Compound:5160441|FD-Score:8.23|P-value:1.54E-19 ID:SGTC_2149|Compound:5554786|FD-Score:3.40|P-value:1.05E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.10|P-value:3.65E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.36|P-value:1.29E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.36|P-value:1.27E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.32|P-value:1.51E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.00|P-value:5.54E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.92|P-value:7.31E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.94|P-value:8.98E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.26|P-value:1.70E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.20|P-value:2.46E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.20|P-value:2.52E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.03|P-value:4.77E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.35|P-value:1.29E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.42|P-value:7.36E-7 ID:SGTC_2986|Compound:9022445|FD-Score:3.85|P-value:1.40E-5 ID:SGTC_3087|Compound:9117406|FD-Score:3.06|P-value:4.37E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.89|P-value:1.11E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-4.53|P-value:3.96E-7 ID:SGTC_3186|Compound:9110464|FD-Score:3.24|P-value:2.06E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.21|P-value:2.22E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-4.62|P-value:2.41E-7

Top fitness defect scores for YPL085W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_913 3487-1245 8.77 167.0 µM 6.12E-22 1 8.66E-19 1.95
2 SGTC_2036 5160441 8.23 105.0 µM 1.54E-19 NEO1 8 9.25E-17 1.16
3 SGTC_464 bw-b 70c 5.54 158.0 µM 7.79E-10 4 1.47E-8 1.30
4 SGTC_1694 st024011 4.70 44.9 µM 1.54E-7 ERG2 3 1.30E-6 0.43
5 SGTC_2973 9094665 4.42 18.0 µM 7.36E-7 NEO1 15 4.89E-6 0.19
6 SGTC_3200 9114385 4.21 49.5 µM 2.22E-6 15 1.25E-5 0.04
7 SGTC_310 1273-0058 4.05 1.1 µM 5.07E-6 mitochondrial stress 1 2.52E-5 0.69
8 SGTC_314 1671-0008 3.96 2.7 µM 8.07E-6 8 3.74E-5 0.10
9 SGTC_2688 kanamycin b 3.94 96.7 µM 8.98E-6 calcium & mitochondrial duress 23 4.09E-5 0.03
10 SGTC_2986 9022445 3.85 71.4 µM 1.40E-5 6 5.97E-5 0.13
11 SGTC_2032 5185112 3.64 26.0 µM 3.62E-5 1 1.34E-4 0.72
12 SGTC_497 capsazepine 3.54 133.0 µM 5.78E-5 9 1.99E-4 0.00
13 SGTC_961 1252-1571 3.54 372.0 µM 5.81E-5 6 2.00E-4 0.01
14 SGTC_925 2064-1272 3.53 59.6 µM 6.20E-5 9 2.11E-4 0.07
15 SGTC_471 1-acyl-paf 3.47 4.0 µM 7.97E-5 DNA intercalators 23 2.62E-4 0.09
16 SGTC_2149 5554786 3.40 194.8 µM 1.05E-4 cell wall signaling 11 3.32E-4 0.05
17 SGTC_286 k060-0067 3.40 22.9 µM 1.09E-4 tubulin folding & SWR complex 13 3.43E-4 0.08
18 SGTC_2288 7946289 3.36 167.3 µM 1.27E-4 10 3.90E-4 0.17
19 SGTC_2286 7945697 3.36 125.0 µM 1.29E-4 19 3.95E-4 0.08
20 SGTC_2329 6138490 3.32 200.0 µM 1.51E-4 20 4.50E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.17E-14 YPL114W_d YPL114W_d hom Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
0.121 2.38E-12 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.119 5.36E-12 YOR351C MEK1 hom Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
0.118 7.14E-12 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.116 1.84E-11 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.116 1.90E-11 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.115 2.11E-11 YMR316C-B_d YMR316C-B_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111 1.15E-10 YNL006W LST8 het Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
0.110 1.59E-10 YDR053W_d YDR053W_d het Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
0.098 1.43E-8 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.098 1.43E-8 YLR218C COA4 hom Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors
0.097 1.98E-8 YHR038W RRF1 hom Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
0.096 2.15E-8 YOR140W SFL1 hom Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
0.094 5.58E-8 YOR276W CAF20 hom Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
0.091 1.36E-7 YKR046C PET10 hom Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange