HIPHOP chemogenomics database

YPL087W / YDC1

Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL087W / YDC1

Click on Significant Values for Screen Details

Top fitness defect scores for YPL087W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1757	st041620	7.10	31.8 µM	3.40E-14		9	6.38E-13
2	SGTC_2286	7945697	6.93	125.0 µM	1.31E-13		10	2.17E-12
3	SGTC_2766	oltipraz	5.93	83.9 µM	1.83E-10	heme requiring	8	1.51E-9
4	SGTC_1277	0873-0036	5.62	22.0 µM	1.45E-9	PDR1	9	9.81E-9
5	SGTC_2835	9006588	5.52	71.4 µM	2.73E-9		12	1.73E-8
6	SGTC_1370	2001-0092	5.47	44.6 µM	3.57E-9		10	2.21E-8
7	SGTC_3212	9128307	5.40	49.5 µM	5.49E-9		21	3.26E-8
8	SGTC_1075	aripiprazole	5.31	15.2 µM	9.80E-9		7	5.50E-8
9	SGTC_2288	7946289	4.85	167.3 µM	1.44E-7		11	6.24E-7
10	SGTC_741	4582-0002	4.47	126.0 µM	1.09E-6		8	3.87E-6
11	SGTC_1677	st019204	4.23	53.9 µM	3.76E-6		11	1.19E-5
12	SGTC_2177	5811945	4.21	192.0 µM	4.12E-6		23	1.29E-5
13	SGTC_1246	0422-0085	4.19	105.0 µM	4.53E-6		22	1.41E-5
14	SGTC_1473	k844-0725	3.97	134.0 µM	1.27E-5		12	3.56E-5
15	SGTC_2045	5106652	3.91	78.0 µM	1.69E-5		12	4.61E-5
16	SGTC_2887	9044784	3.84	58.4 µM	2.35E-5	fatty acid desaturase (OLE1)	29	6.22E-5
17	SGTC_1586	deoxycorticosterone acetate	3.80	53.7 µM	2.80E-5		13	7.28E-5
18	SGTC_2147	5545932	3.76	89.7 µM	3.33E-5	ergosterol biosynthesis	16	8.52E-5
19	SGTC_179	1273-0063	3.75	6.8 µM	3.41E-5		27	8.71E-5
20	SGTC_2473	5854593	3.75	8.9 µM	3.51E-5		16	8.93E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.095	3.52E-8	YBL098W	BNA4	hom	Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.094	4.50E-8	YMR172W	HOT1	hom	Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
0.085	9.30E-7	YDR210W_p	YDR210W_p	hom	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.085	9.54E-7	YGR110W	CLD1	hom	Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.084	1.13E-6	YPL167C	REV3	hom	Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.081	2.69E-6	YER023W	PRO3	het	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.080	3.59E-6	YHL021C	AIM17	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.079	4.76E-6	YML069W	POB3	het	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.079	5.05E-6	YMR005W	TAF4	het	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
0.079	5.31E-6	YBR171W	SEC66	hom	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.078	6.47E-6	YDR291W	HRQ1	hom	3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.077	7.70E-6	YNL316C	PHA2	hom	Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
0.076	1.03E-5	YLR079W	SIC1	hom	Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
0.075	1.50E-5	YOR290C	SNF2	hom	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
0.073	2.13E-5	YOR379C_d	YOR379C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W