YPL087W / YDC1

Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL087W / YDC1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:-3.05|P-value:7.76E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.75|P-value:3.41E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-4.19|P-value:6.51E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.31|P-value:2.22E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:2.95|P-value:8.46E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.63|P-value:5.95E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.59|P-value:6.99E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.52|P-value:9.38E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:4.47|P-value:1.09E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:3.24|P-value:2.86E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.23|P-value:4.01E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.27|P-value:3.54E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.27|P-value:2.54E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.20|P-value:4.60E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:2.98|P-value:7.51E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.85|P-value:3.17E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.09|P-value:5.11E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:5.31|P-value:9.80E-9 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.35|P-value:1.88E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.19|P-value:4.53E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:2.95|P-value:8.36E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:5.62|P-value:1.45E-9 ID:SGTC_1370|Compound:2001-0092|FD-Score:5.47|P-value:3.57E-9 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.97|P-value:1.27E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.80|P-value:2.80E-5 ID:SGTC_1677|Compound:st019204|FD-Score:4.23|P-value:3.76E-6 ID:SGTC_1757|Compound:st041620|FD-Score:7.10|P-value:3.40E-14 ID:SGTC_1845|Compound:st056753|FD-Score:2.96|P-value:8.07E-4 ID:SGTC_1958|Compound:st076513|FD-Score:2.95|P-value:8.48E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.91|P-value:1.69E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.31|P-value:2.23E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.06|P-value:7.53E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.76|P-value:3.33E-5 ID:SGTC_2177|Compound:5811945|FD-Score:4.21|P-value:4.12E-6 ID:SGTC_2184|Compound:6075246|FD-Score:3.68|P-value:4.68E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.38|P-value:1.63E-4 ID:SGTC_2286|Compound:7945697|FD-Score:6.93|P-value:1.31E-13 ID:SGTC_2288|Compound:7946289|FD-Score:4.85|P-value:1.44E-7 ID:SGTC_2462|Compound:5162487|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.75|P-value:3.51E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:2.92|P-value:9.53E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.46|P-value:1.18E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.10|P-value:4.86E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-5.13|P-value:4.65E-8 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.93|P-value:1.83E-10 ID:SGTC_2767|Compound:sibutramine|FD-Score:-5.43|P-value:7.85E-9 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.54|P-value:8.49E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.40|P-value:1.53E-4 ID:SGTC_2835|Compound:9006588|FD-Score:5.52|P-value:2.73E-9 ID:SGTC_2838|Compound:9002687|FD-Score:-3.61|P-value:8.78E-5 ID:SGTC_2868|Compound:9035608|FD-Score:-3.56|P-value:1.11E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.14|P-value:4.18E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.84|P-value:2.35E-5 ID:SGTC_2921|Compound:7974240|FD-Score:2.99|P-value:7.31E-4 ID:SGTC_3096|Compound:9117468|FD-Score:3.05|P-value:5.81E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.12|P-value:6.16E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.27|P-value:3.51E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.30|P-value:3.10E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.40|P-value:5.49E-9 ID:SGTC_17|Compound:0960-0276|FD-Score:-3.05|P-value:7.76E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.75|P-value:3.41E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-4.19|P-value:6.51E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.31|P-value:2.22E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:2.95|P-value:8.46E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.63|P-value:5.95E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.59|P-value:6.99E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.52|P-value:9.38E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:4.47|P-value:1.09E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:3.24|P-value:2.86E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.23|P-value:4.01E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.27|P-value:3.54E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.27|P-value:2.54E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.20|P-value:4.60E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:2.98|P-value:7.51E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.85|P-value:3.17E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.09|P-value:5.11E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:5.31|P-value:9.80E-9 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.35|P-value:1.88E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.19|P-value:4.53E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:2.95|P-value:8.36E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:5.62|P-value:1.45E-9 ID:SGTC_1370|Compound:2001-0092|FD-Score:5.47|P-value:3.57E-9 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.97|P-value:1.27E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.80|P-value:2.80E-5 ID:SGTC_1677|Compound:st019204|FD-Score:4.23|P-value:3.76E-6 ID:SGTC_1757|Compound:st041620|FD-Score:7.10|P-value:3.40E-14 ID:SGTC_1845|Compound:st056753|FD-Score:2.96|P-value:8.07E-4 ID:SGTC_1958|Compound:st076513|FD-Score:2.95|P-value:8.48E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.91|P-value:1.69E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.31|P-value:2.23E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.06|P-value:7.53E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.76|P-value:3.33E-5 ID:SGTC_2177|Compound:5811945|FD-Score:4.21|P-value:4.12E-6 ID:SGTC_2184|Compound:6075246|FD-Score:3.68|P-value:4.68E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.38|P-value:1.63E-4 ID:SGTC_2286|Compound:7945697|FD-Score:6.93|P-value:1.31E-13 ID:SGTC_2288|Compound:7946289|FD-Score:4.85|P-value:1.44E-7 ID:SGTC_2462|Compound:5162487|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.75|P-value:3.51E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:2.92|P-value:9.53E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.46|P-value:1.18E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.10|P-value:4.86E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-5.13|P-value:4.65E-8 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.93|P-value:1.83E-10 ID:SGTC_2767|Compound:sibutramine|FD-Score:-5.43|P-value:7.85E-9 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.54|P-value:8.49E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.40|P-value:1.53E-4 ID:SGTC_2835|Compound:9006588|FD-Score:5.52|P-value:2.73E-9 ID:SGTC_2838|Compound:9002687|FD-Score:-3.61|P-value:8.78E-5 ID:SGTC_2868|Compound:9035608|FD-Score:-3.56|P-value:1.11E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.14|P-value:4.18E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.84|P-value:2.35E-5 ID:SGTC_2921|Compound:7974240|FD-Score:2.99|P-value:7.31E-4 ID:SGTC_3096|Compound:9117468|FD-Score:3.05|P-value:5.81E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.12|P-value:6.16E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.27|P-value:3.51E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.30|P-value:3.10E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.40|P-value:5.49E-9

Top fitness defect scores for YPL087W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1757 st041620 7.10 31.8 µM 3.40E-14 9 6.38E-13
2 SGTC_2286 7945697 6.93 125.0 µM 1.31E-13 10 2.17E-12
3 SGTC_2766 oltipraz 5.93 83.9 µM 1.83E-10 heme requiring 8 1.51E-9
4 SGTC_1277 0873-0036 5.62 22.0 µM 1.45E-9 PDR1 9 9.81E-9
5 SGTC_2835 9006588 5.52 71.4 µM 2.73E-9 12 1.73E-8
6 SGTC_1370 2001-0092 5.47 44.6 µM 3.57E-9 10 2.21E-8
7 SGTC_3212 9128307 5.40 49.5 µM 5.49E-9 21 3.26E-8
8 SGTC_1075 aripiprazole 5.31 15.2 µM 9.80E-9 7 5.50E-8
9 SGTC_2288 7946289 4.85 167.3 µM 1.44E-7 11 6.24E-7
10 SGTC_741 4582-0002 4.47 126.0 µM 1.09E-6 8 3.87E-6
11 SGTC_1677 st019204 4.23 53.9 µM 3.76E-6 11 1.19E-5
12 SGTC_2177 5811945 4.21 192.0 µM 4.12E-6 23 1.29E-5
13 SGTC_1246 0422-0085 4.19 105.0 µM 4.53E-6 22 1.41E-5
14 SGTC_1473 k844-0725 3.97 134.0 µM 1.27E-5 12 3.56E-5
15 SGTC_2045 5106652 3.91 78.0 µM 1.69E-5 12 4.61E-5
16 SGTC_2887 9044784 3.84 58.4 µM 2.35E-5 fatty acid desaturase (OLE1) 29 6.22E-5
17 SGTC_1586 deoxycorticosterone acetate 3.80 53.7 µM 2.80E-5 13 7.28E-5
18 SGTC_2147 5545932 3.76 89.7 µM 3.33E-5 ergosterol biosynthesis 16 8.52E-5
19 SGTC_179 1273-0063 3.75 6.8 µM 3.41E-5 27 8.71E-5
20 SGTC_2473 5854593 3.75 8.9 µM 3.51E-5 16 8.93E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.52E-8 YBL098W BNA4 hom Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.094 4.50E-8 YMR172W HOT1 hom Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
0.085 9.30E-7 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.085 9.54E-7 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.084 1.13E-6 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.081 2.69E-6 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.080 3.59E-6 YHL021C AIM17 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.079 4.76E-6 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.079 5.05E-6 YMR005W TAF4 het TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
0.079 5.31E-6 YBR171W SEC66 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.078 6.47E-6 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.077 7.70E-6 YNL316C PHA2 hom Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
0.076 1.03E-5 YLR079W SIC1 hom Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
0.075 1.50E-5 YOR290C SNF2 hom Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
0.073 2.13E-5 YOR379C_d YOR379C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W