YPL088W_p

Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL088W / YPL088W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.33|P-value:4.59E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.57|P-value:1.87E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.93|P-value:4.52E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-4.91|P-value:6.00E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.35|P-value:4.31E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.22|P-value:1.32E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.46|P-value:4.47E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.33|P-value:4.49E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.44|P-value:4.97E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.22|P-value:1.03E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.38|P-value:3.78E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:5.47|P-value:2.68E-8 ID:SGTC_1450|Compound:4112-4260|FD-Score:-4.29|P-value:1.08E-5 ID:SGTC_1726|Compound:st035556|FD-Score:5.29|P-value:6.97E-8 ID:SGTC_1745|Compound:st081495|FD-Score:3.82|P-value:7.09E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-3.57|P-value:2.10E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.22|P-value:6.70E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.67|P-value:1.30E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-4.05|P-value:3.09E-5 ID:SGTC_2220|Compound:6782180|FD-Score:3.42|P-value:3.27E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.21|P-value:7.57E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.19|P-value:7.44E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.51|P-value:2.38E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.62|P-value:1.58E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.33|P-value:4.60E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.77|P-value:1.02E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.40|P-value:3.59E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.75|P-value:9.56E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.36|P-value:4.12E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-4.88|P-value:6.94E-7 ID:SGTC_3291|Compound:9121177|FD-Score:3.26|P-value:5.88E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-4.65|P-value:2.12E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.33|P-value:4.59E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.57|P-value:1.87E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.93|P-value:4.52E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-4.91|P-value:6.00E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.35|P-value:4.31E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.22|P-value:1.32E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.46|P-value:4.47E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.33|P-value:4.49E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.44|P-value:4.97E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.22|P-value:1.03E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.38|P-value:3.78E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:5.47|P-value:2.68E-8 ID:SGTC_1450|Compound:4112-4260|FD-Score:-4.29|P-value:1.08E-5 ID:SGTC_1726|Compound:st035556|FD-Score:5.29|P-value:6.97E-8 ID:SGTC_1745|Compound:st081495|FD-Score:3.82|P-value:7.09E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-3.57|P-value:2.10E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.22|P-value:6.70E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.67|P-value:1.30E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-4.05|P-value:3.09E-5 ID:SGTC_2220|Compound:6782180|FD-Score:3.42|P-value:3.27E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.21|P-value:7.57E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.19|P-value:7.44E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.51|P-value:2.38E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.62|P-value:1.58E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.33|P-value:4.60E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.77|P-value:1.02E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.40|P-value:3.59E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.75|P-value:9.56E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.36|P-value:4.12E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-4.88|P-value:6.94E-7 ID:SGTC_3291|Compound:9121177|FD-Score:3.26|P-value:5.88E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-4.65|P-value:2.12E-6

Top fitness defect scores for YPL088W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1404 3909-7820 5.47 48.3 µM 2.68E-8 60S ribosome export 3 2.27E-8
2 SGTC_1726 st035556 5.29 14.6 µM 6.97E-8 16 5.98E-8
3 SGTC_1373 2887-0003 5.22 58.5 µM 1.03E-7 Golgi 5 8.89E-8
4 SGTC_3198 9112019 4.77 49.5 µM 1.02E-6 mitochondrial processes 5 9.03E-7
5 SGTC_733 4069-0007 4.46 56.1 µM 4.47E-6 ERAD & cell cycle 72 4.04E-6
6 SGTC_1370 2001-0092 4.44 44.6 µM 4.97E-6 19 4.50E-6
7 SGTC_520 3584-0023 4.22 682.0 µM 1.32E-5 21 1.21E-5
8 SGTC_324 1315-0088 3.93 19.6 µM 4.52E-5 RSC & ERG11 10 4.20E-5
9 SGTC_1745 st081495 3.82 74.0 µM 7.09E-5 RNA processing & uracil transport 78 6.62E-5
10 SGTC_3207 9114163 3.75 49.5 µM 9.56E-5 38 8.96E-5
11 SGTC_2150 5556613 3.67 200.0 µM 1.30E-4 24 1.22E-4
12 SGTC_3002 9075603 3.62 71.4 µM 1.58E-4 31 1.49E-4
13 SGTC_154 3389-1638 3.57 511.1 µM 1.87E-4 35 1.77E-4
14 SGTC_2768 sulfasalazine 3.51 50.2 µM 2.38E-4 29 2.26E-4
15 SGTC_2220 6782180 3.42 200.0 µM 3.27E-4 RNA processing & uracil transport 12 3.11E-4
16 SGTC_3203 9113543 3.40 49.5 µM 3.59E-4 49 3.42E-4
17 SGTC_1381 2324-0066 3.38 62.1 µM 3.78E-4 48 3.60E-4
18 SGTC_3282 9108498 3.36 15.5 µM 4.12E-4 49 3.92E-4
19 SGTC_501 nsc-95397 3.35 161.0 µM 4.31E-4 26 4.11E-4
20 SGTC_1075 aripiprazole 3.33 15.2 µM 4.49E-4 59 4.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.77E-10 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.101 4.90E-9 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.097 1.73E-8 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.094 5.37E-8 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.091 1.38E-7 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.088 3.02E-7 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.088 3.36E-7 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.087 4.93E-7 YLR045C STU2 het Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
0.086 6.41E-7 YBR011C IPP1 het Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
0.085 7.38E-7 YNL127W FAR11 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2
0.083 1.32E-6 YLR306W UBC12 hom Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes
0.083 1.37E-6 YIR018W YAP5 hom Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication
0.083 1.50E-6 YKL204W EAP1 hom eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade
0.082 1.98E-6 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.082 2.27E-6 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids