YPL094C / SEC62

Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL094C / SEC62

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.16|P-value:6.18E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.08|P-value:6.38E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.90|P-value:2.17E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.77|P-value:3.82E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.22|P-value:4.76E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:5.25|P-value:1.61E-8 ID:SGTC_204|Compound:1543-0184|FD-Score:3.12|P-value:5.50E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.09|P-value:6.20E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:-3.17|P-value:3.21E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.18|P-value:4.36E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.04|P-value:7.29E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.23|P-value:1.86E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:3.43|P-value:1.64E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.04|P-value:5.17E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.00|P-value:1.35E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.19|P-value:4.22E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-2.97|P-value:6.91E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.20|P-value:4.03E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.06|P-value:1.01E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.07|P-value:6.55E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.86|P-value:1.57E-7 ID:SGTC_642|Compound:0335-0876|FD-Score:3.59|P-value:8.34E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:4.21|P-value:4.91E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:3.12|P-value:5.52E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.53|P-value:9.48E-7 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.33|P-value:9.96E-9 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.61|P-value:7.60E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:3.12|P-value:5.51E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.09|P-value:6.24E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.97|P-value:9.56E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:2.99|P-value:8.74E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.12|P-value:5.59E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-2.97|P-value:6.75E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.34|P-value:1.64E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.27|P-value:3.09E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.94|P-value:1.03E-7 ID:SGTC_1672|Compound:st016598|FD-Score:4.39|P-value:2.01E-6 ID:SGTC_1682|Compound:st012968|FD-Score:-3.47|P-value:9.59E-5 ID:SGTC_1739|Compound:st037196|FD-Score:2.97|P-value:9.63E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.46|P-value:1.47E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.37|P-value:2.06E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.05|P-value:7.17E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.13|P-value:5.40E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.29|P-value:2.89E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.03|P-value:7.61E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.03|P-value:1.17E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-4.08|P-value:5.77E-6 ID:SGTC_2390|Compound:9097792|FD-Score:3.10|P-value:5.86E-4 ID:SGTC_2482|Compound:5981709|FD-Score:2.97|P-value:9.60E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.59|P-value:8.43E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.02|P-value:5.67E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.13|P-value:5.39E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.39|P-value:1.33E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.03|P-value:5.47E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.27|P-value:3.12E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.80|P-value:3.41E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.36|P-value:2.18E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.21|P-value:3.84E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.75|P-value:4.21E-5 ID:SGTC_3118|Compound:9124250|FD-Score:3.57|P-value:9.04E-5 ID:SGTC_3157|Compound:9099274|FD-Score:5.27|P-value:1.48E-8 ID:SGTC_3202|Compound:9113761|FD-Score:3.52|P-value:1.14E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.16|P-value:6.18E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.08|P-value:6.38E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.90|P-value:2.17E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.77|P-value:3.82E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.22|P-value:4.76E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:5.25|P-value:1.61E-8 ID:SGTC_204|Compound:1543-0184|FD-Score:3.12|P-value:5.50E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.09|P-value:6.20E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:-3.17|P-value:3.21E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.18|P-value:4.36E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.04|P-value:7.29E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.23|P-value:1.86E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:3.43|P-value:1.64E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.04|P-value:5.17E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.00|P-value:1.35E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.19|P-value:4.22E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-2.97|P-value:6.91E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.20|P-value:4.03E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.06|P-value:1.01E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.07|P-value:6.55E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.86|P-value:1.57E-7 ID:SGTC_642|Compound:0335-0876|FD-Score:3.59|P-value:8.34E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:4.21|P-value:4.91E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:3.12|P-value:5.52E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.53|P-value:9.48E-7 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.33|P-value:9.96E-9 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.61|P-value:7.60E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:3.12|P-value:5.51E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.09|P-value:6.24E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.97|P-value:9.56E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:2.99|P-value:8.74E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.12|P-value:5.59E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-2.97|P-value:6.75E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.34|P-value:1.64E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.27|P-value:3.09E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.94|P-value:1.03E-7 ID:SGTC_1672|Compound:st016598|FD-Score:4.39|P-value:2.01E-6 ID:SGTC_1682|Compound:st012968|FD-Score:-3.47|P-value:9.59E-5 ID:SGTC_1739|Compound:st037196|FD-Score:2.97|P-value:9.63E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.46|P-value:1.47E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.37|P-value:2.06E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.05|P-value:7.17E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.13|P-value:5.40E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.29|P-value:2.89E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.03|P-value:7.61E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.03|P-value:1.17E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-4.08|P-value:5.77E-6 ID:SGTC_2390|Compound:9097792|FD-Score:3.10|P-value:5.86E-4 ID:SGTC_2482|Compound:5981709|FD-Score:2.97|P-value:9.60E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.59|P-value:8.43E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.02|P-value:5.67E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.13|P-value:5.39E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.39|P-value:1.33E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.03|P-value:5.47E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.27|P-value:3.12E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.80|P-value:3.41E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.36|P-value:2.18E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.21|P-value:3.84E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.75|P-value:4.21E-5 ID:SGTC_3118|Compound:9124250|FD-Score:3.57|P-value:9.04E-5 ID:SGTC_3157|Compound:9099274|FD-Score:5.27|P-value:1.48E-8 ID:SGTC_3202|Compound:9113761|FD-Score:3.52|P-value:1.14E-4

Top fitness defect scores for YPL094C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1012 4112-3522 5.33 18.0 µM 9.96E-9 2 4.83E-8 1.62
2 SGTC_3157 9099274 5.27 49.5 µM 1.48E-8 1 6.89E-8 0.60
3 SGTC_200 k038-0079 5.25 37.5 µM 1.61E-8 ubiquinone biosynthesis & proteasome 6 7.43E-8 0.54
4 SGTC_367 0335-0881 5.23 7.1 µM 1.86E-8 ubiquinone biosynthesis & proteasome 11 8.45E-8 0.08
5 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 4.94 19.1 µM 1.03E-7 2 3.93E-7 1.04
6 SGTC_635 k038-0028 4.86 24.7 µM 1.57E-7 ubiquinone biosynthesis & proteasome 8 5.75E-7 0.23
7 SGTC_958 1222-0007 4.53 33.0 µM 9.48E-7 2 2.90E-6 0.36
8 SGTC_1672 st016598 4.39 6.5 µM 2.01E-6 endomembrane recycling 15 5.71E-6 0.03
9 SGTC_158 k038-0087 4.22 26.4 µM 4.76E-6 ubiquinone biosynthesis & proteasome 30 1.24E-5 0.04
10 SGTC_700 3453-2283 4.21 142.0 µM 4.91E-6 amide catabolism 6 1.27E-5 0.10
11 SGTC_18 0111-0177 4.16 500.0 nM 6.18E-6 4 1.57E-5 0.42
12 SGTC_619 1652-1634 4.06 108.0 µM 1.01E-5 PDR1 6 2.44E-5 0.38
13 SGTC_2354 9060492 4.03 162.0 µM 1.17E-5 6 2.79E-5 0.32
14 SGTC_429 1112-0049 4.00 25.5 µM 1.35E-5 DNA damage response 10 3.17E-5 0.30
15 SGTC_99 0109-0120 3.90 622.8 µM 2.17E-5 5 4.86E-5 0.07
16 SGTC_2913 7966556 3.80 36.6 µM 3.41E-5 60S ribosome export 9 7.30E-5 0.17
17 SGTC_137 0438-0332 3.77 85.4 µM 3.82E-5 ubiquinone biosynthesis & proteasome 47 8.09E-5 0.03
18 SGTC_3100 9120536 3.75 49.5 µM 4.21E-5 10 8.83E-5 0.12
19 SGTC_1020 4335-0961 3.61 93.3 µM 7.60E-5 9 1.51E-4 0.03
20 SGTC_642 0335-0876 3.59 158.0 µM 8.34E-5 ubiquinone biosynthesis & proteasome 12 1.64E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.30E-29 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.191 5.01E-29 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.175 2.01E-24 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.174 3.37E-24 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.169 6.11E-23 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.165 5.81E-22 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.163 2.11E-21 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.158 3.25E-20 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.157 5.81E-20 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.152 6.43E-19 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.149 3.63E-18 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.139 5.13E-16 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.135 4.66E-15 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.128 1.14E-13 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.23E-13 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p