YPL095C / EEB1

Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL095C / EEB1

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-4.28|P-value:2.78E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.95|P-value:1.06E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.38|P-value:7.61E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.29|P-value:9.56E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.77|P-value:1.89E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.38|P-value:7.76E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.48|P-value:1.23E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-3.43|P-value:6.21E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.61|P-value:3.60E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:4.00|P-value:8.82E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.73|P-value:2.33E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.10|P-value:5.98E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.86|P-value:2.59E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.76|P-value:2.02E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.43|P-value:6.59E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.35|P-value:8.57E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.51|P-value:5.00E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.94|P-value:1.08E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.49|P-value:5.43E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.23|P-value:3.67E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.87|P-value:1.42E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.40|P-value:7.20E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.53|P-value:4.71E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.88|P-value:2.35E-6 ID:SGTC_1959|Compound:st077091|FD-Score:5.79|P-value:2.71E-8 ID:SGTC_2086|Compound:5274770|FD-Score:-3.34|P-value:8.27E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-4.74|P-value:4.00E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.33|P-value:9.01E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-4.97|P-value:1.47E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.48|P-value:5.30E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.40|P-value:7.21E-4 ID:SGTC_2570|Compound:licareol|FD-Score:6.36|P-value:1.23E-9 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.20|P-value:4.10E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.25|P-value:3.39E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.97|P-value:9.26E-5 ID:SGTC_2804|Compound:7954240|FD-Score:4.93|P-value:1.86E-6 ID:SGTC_2805|Compound:7950783|FD-Score:-3.61|P-value:3.42E-4 ID:SGTC_2808|Compound:7946468|FD-Score:4.24|P-value:3.56E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.52|P-value:4.53E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.39|P-value:7.53E-4 ID:SGTC_2863|Compound:9028737|FD-Score:4.73|P-value:4.64E-6 ID:SGTC_2922|Compound:7999257|FD-Score:-4.51|P-value:1.09E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-5.33|P-value:2.63E-7 ID:SGTC_3242|Compound:9133940|FD-Score:3.64|P-value:3.21E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-4.28|P-value:2.78E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.95|P-value:1.06E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.38|P-value:7.61E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.29|P-value:9.56E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.77|P-value:1.89E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.38|P-value:7.76E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.48|P-value:1.23E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-3.43|P-value:6.21E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.61|P-value:3.60E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:4.00|P-value:8.82E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.73|P-value:2.33E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.10|P-value:5.98E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.86|P-value:2.59E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.76|P-value:2.02E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.43|P-value:6.59E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.35|P-value:8.57E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.51|P-value:5.00E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.94|P-value:1.08E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.49|P-value:5.43E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.23|P-value:3.67E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.87|P-value:1.42E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.40|P-value:7.20E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.53|P-value:4.71E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.88|P-value:2.35E-6 ID:SGTC_1959|Compound:st077091|FD-Score:5.79|P-value:2.71E-8 ID:SGTC_2086|Compound:5274770|FD-Score:-3.34|P-value:8.27E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-4.74|P-value:4.00E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.33|P-value:9.01E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-4.97|P-value:1.47E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.48|P-value:5.30E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.40|P-value:7.21E-4 ID:SGTC_2570|Compound:licareol|FD-Score:6.36|P-value:1.23E-9 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.20|P-value:4.10E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.25|P-value:3.39E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.97|P-value:9.26E-5 ID:SGTC_2804|Compound:7954240|FD-Score:4.93|P-value:1.86E-6 ID:SGTC_2805|Compound:7950783|FD-Score:-3.61|P-value:3.42E-4 ID:SGTC_2808|Compound:7946468|FD-Score:4.24|P-value:3.56E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.52|P-value:4.53E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.39|P-value:7.53E-4 ID:SGTC_2863|Compound:9028737|FD-Score:4.73|P-value:4.64E-6 ID:SGTC_2922|Compound:7999257|FD-Score:-4.51|P-value:1.09E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-5.33|P-value:2.63E-7 ID:SGTC_3242|Compound:9133940|FD-Score:3.64|P-value:3.21E-4

Top fitness defect scores for YPL095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2570 licareol 6.36 100.0 µM 1.23E-9 3 1.04E-10
2 SGTC_1959 st077091 5.79 55.8 µM 2.71E-8 RPP1 & pyrimidine depletion 12 3.44E-9
3 SGTC_2804 7954240 4.93 19.5 µM 1.86E-6 11 4.08E-7
4 SGTC_1893 st059353 4.88 36.1 µM 2.35E-6 10 5.30E-7
5 SGTC_1045 1348-1485 4.86 165.0 µM 2.59E-6 11 5.94E-7
6 SGTC_2863 9028737 4.73 58.4 µM 4.64E-6 1 1.14E-6
7 SGTC_2766 oltipraz 4.25 83.9 µM 3.39E-5 heme requiring 21 1.08E-5
8 SGTC_2808 7946468 4.24 45.5 µM 3.56E-5 16 1.14E-5
9 SGTC_1609 st001574 4.23 46.4 µM 3.67E-5 8 1.18E-5
10 SGTC_2763 lisinopril 4.20 49.3 µM 4.10E-5 10 1.34E-5
11 SGTC_1041 0206-0046 4.10 107.0 µM 5.98E-5 32 2.05E-5
12 SGTC_848 0368-0089 4.00 85.6 µM 8.82E-5 iron homeostasis 12 3.17E-5
13 SGTC_72 0744-0168 3.95 198.4 µM 1.06E-4 RPP1 & pyrimidine depletion 28 3.92E-5
14 SGTC_1539 benzyladenosine 3.94 56.0 µM 1.08E-4 16 3.99E-5
15 SGTC_1680 diphenhydramine 3.87 100.0 µM 1.42E-4 NEO1 30 5.43E-5
16 SGTC_1027 k015-0025 3.73 8.7 µM 2.33E-4 31 9.48E-5
17 SGTC_3242 9133940 3.64 49.5 µM 3.21E-4 16 1.36E-4
18 SGTC_648 0375-0473 3.61 33.3 µM 3.60E-4 24 1.55E-4
19 SGTC_1841 st054148 3.53 70.0 µM 4.71E-4 18 2.10E-4
20 SGTC_1375 2910-0797 3.51 186.0 µM 5.00E-4 43 2.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.95E-15 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.102 2.98E-9 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.102 3.44E-9 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.097 1.95E-8 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.095 3.50E-8 YBR043C QDR3 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.085 8.35E-7 YPL211W NIP7 het Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
0.084 1.06E-6 YOR316C-A_p YOR316C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.082 2.10E-6 YML080W DUS1 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
0.080 3.14E-6 YLR233C EST1 hom TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA
0.080 3.58E-6 YKR083C DAD2 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.080 3.57E-6 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.077 7.10E-6 YML023C NSE5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.075 1.27E-5 YFL041W-A_p YFL041W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.075 1.28E-5 YDL004W ATP16 het Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.074 1.85E-5 YMR182C RGM1 hom Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication