YPL096C-A / ERI1

Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL096C-A / ERI1

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:4.31|P-value:8.16E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.74|P-value:5.40E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.18|P-value:1.09E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.33|P-value:7.65E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.54|P-value:2.98E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:3.64|P-value:7.26E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.69|P-value:6.32E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.39|P-value:5.99E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:3.92|P-value:2.99E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.54|P-value:3.59E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.88|P-value:9.49E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:3.64|P-value:7.30E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.59|P-value:2.91E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.84|P-value:3.98E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.04|P-value:2.03E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.86|P-value:3.69E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.49|P-value:9.82E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.65|P-value:6.98E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.23|P-value:1.05E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.63|P-value:7.63E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.10|P-value:4.04E-6 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:5.09|P-value:4.08E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.47|P-value:4.61E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.71|P-value:5.94E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.77|P-value:4.93E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.24|P-value:1.05E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.68|P-value:5.59E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.90|P-value:3.21E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-5.43|P-value:8.06E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.51|P-value:5.68E-7 ID:SGTC_1829|Compound:berberine|FD-Score:-3.52|P-value:8.97E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.85|P-value:3.85E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.84|P-value:3.90E-4 ID:SGTC_1891|Compound:st059073|FD-Score:5.62|P-value:4.20E-7 ID:SGTC_1933|Compound:st074711|FD-Score:5.26|P-value:2.07E-6 ID:SGTC_2065|Compound:5221596|FD-Score:-3.58|P-value:7.57E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.66|P-value:2.27E-5 ID:SGTC_2119|Compound:5528445|FD-Score:4.13|P-value:1.49E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.76|P-value:5.04E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.11|P-value:1.38E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.43|P-value:5.20E-5 ID:SGTC_2292|Compound:7671323|FD-Score:5.46|P-value:8.73E-7 ID:SGTC_2293|Compound:7624732|FD-Score:4.43|P-value:5.35E-5 ID:SGTC_2342|Compound:7990637|FD-Score:4.94|P-value:7.50E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.92|P-value:3.05E-4 ID:SGTC_2370|Compound:9071495|FD-Score:6.43|P-value:8.61E-9 ID:SGTC_2416|Compound:tofa|FD-Score:3.60|P-value:8.21E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.64|P-value:7.37E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.29|P-value:8.65E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:6.08|P-value:4.86E-8 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.55|P-value:9.65E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.71|P-value:5.05E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.54|P-value:9.87E-4 ID:SGTC_2744|Compound:captopril|FD-Score:4.36|P-value:6.83E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.49|P-value:9.93E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.98|P-value:2.46E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.65|P-value:6.18E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.68|P-value:1.73E-5 ID:SGTC_3122|Compound:9126309|FD-Score:5.53|P-value:6.19E-7 ID:SGTC_3151|Compound:9099821|FD-Score:-4.71|P-value:1.55E-5 ID:SGTC_3210|Compound:9128157|FD-Score:4.20|P-value:1.19E-4 ID:SGTC_3244|Compound:9134489|FD-Score:4.11|P-value:1.60E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.74|P-value:5.42E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:4.31|P-value:8.16E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.74|P-value:5.40E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.18|P-value:1.09E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.33|P-value:7.65E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.54|P-value:2.98E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:3.64|P-value:7.26E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.69|P-value:6.32E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.39|P-value:5.99E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:3.92|P-value:2.99E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.54|P-value:3.59E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.88|P-value:9.49E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:3.64|P-value:7.30E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.59|P-value:2.91E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.84|P-value:3.98E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.04|P-value:2.03E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.86|P-value:3.69E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.49|P-value:9.82E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.65|P-value:6.98E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.23|P-value:1.05E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.63|P-value:7.63E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.10|P-value:4.04E-6 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:5.09|P-value:4.08E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.47|P-value:4.61E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.71|P-value:5.94E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.77|P-value:4.93E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.24|P-value:1.05E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.68|P-value:5.59E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.90|P-value:3.21E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-5.43|P-value:8.06E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.51|P-value:5.68E-7 ID:SGTC_1829|Compound:berberine|FD-Score:-3.52|P-value:8.97E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.85|P-value:3.85E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.84|P-value:3.90E-4 ID:SGTC_1891|Compound:st059073|FD-Score:5.62|P-value:4.20E-7 ID:SGTC_1933|Compound:st074711|FD-Score:5.26|P-value:2.07E-6 ID:SGTC_2065|Compound:5221596|FD-Score:-3.58|P-value:7.57E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.66|P-value:2.27E-5 ID:SGTC_2119|Compound:5528445|FD-Score:4.13|P-value:1.49E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.76|P-value:5.04E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.11|P-value:1.38E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.43|P-value:5.20E-5 ID:SGTC_2292|Compound:7671323|FD-Score:5.46|P-value:8.73E-7 ID:SGTC_2293|Compound:7624732|FD-Score:4.43|P-value:5.35E-5 ID:SGTC_2342|Compound:7990637|FD-Score:4.94|P-value:7.50E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.92|P-value:3.05E-4 ID:SGTC_2370|Compound:9071495|FD-Score:6.43|P-value:8.61E-9 ID:SGTC_2416|Compound:tofa|FD-Score:3.60|P-value:8.21E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.64|P-value:7.37E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.29|P-value:8.65E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:6.08|P-value:4.86E-8 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.55|P-value:9.65E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.71|P-value:5.05E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.54|P-value:9.87E-4 ID:SGTC_2744|Compound:captopril|FD-Score:4.36|P-value:6.83E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.49|P-value:9.93E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.98|P-value:2.46E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.65|P-value:6.18E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.68|P-value:1.73E-5 ID:SGTC_3122|Compound:9126309|FD-Score:5.53|P-value:6.19E-7 ID:SGTC_3151|Compound:9099821|FD-Score:-4.71|P-value:1.55E-5 ID:SGTC_3210|Compound:9128157|FD-Score:4.20|P-value:1.19E-4 ID:SGTC_3244|Compound:9134489|FD-Score:4.11|P-value:1.60E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.74|P-value:5.42E-4

Top fitness defect scores for YPL096C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2370 9071495 6.43 200.0 µM 8.61E-9 mitochondrial processes 5 6.37E-11
2 SGTC_2628 lathosterol 6.08 100.0 µM 4.86E-8 5 5.91E-10
3 SGTC_1891 st059073 5.62 26.2 µM 4.20E-7 TSC3-RPN4 7 9.48E-9
4 SGTC_3122 9126309 5.53 49.5 µM 6.19E-7 cell wall signaling 3 1.56E-8
5 SGTC_2292 7671323 5.46 168.1 µM 8.73E-7 RNA processing & uracil transport 12 2.43E-8
6 SGTC_1933 st074711 5.26 15.9 µM 2.07E-6 16 7.39E-8
7 SGTC_1394 3474-0001 5.10 65.7 µM 4.04E-6 endomembrane recycling 21 1.74E-7
8 SGTC_1420 4'-methoxyflavone 5.09 42.0 µM 4.08E-6 2 1.76E-7
9 SGTC_2342 7990637 4.94 118.9 µM 7.50E-6 RNA processing & uracil transport 14 3.85E-7
10 SGTC_710 3448-4187 4.88 58.0 µM 9.49E-6 fatty acid desaturase (OLE1) 28 5.21E-7
11 SGTC_2083 5306046 4.66 65.9 µM 2.27E-5 10 1.60E-6
12 SGTC_851 0394-0702 4.59 453.0 µM 2.91E-5 mitochondrial processes 2 2.19E-6
13 SGTC_708 3448-5400 4.54 146.0 µM 3.59E-5 26 2.87E-6
14 SGTC_1446 4239-0190 4.47 62.0 µM 4.61E-5 24 3.97E-6
15 SGTC_2289 7946404 4.43 165.1 µM 5.20E-5 76 4.62E-6
16 SGTC_2293 7624732 4.43 200.0 µM 5.35E-5 18 4.79E-6
17 SGTC_686 1319-0111 4.39 510.0 µM 5.99E-5 60S ribosome export 20 5.54E-6
18 SGTC_2744 captopril 4.36 92.0 µM 6.83E-5 60S ribosome export 7 6.55E-6
19 SGTC_238 5hr heat shock (37°C) + nsc-638432 4.33 8.9 µM 7.65E-5 heat shock/prefoldin 32 7.58E-6
20 SGTC_34 0469-0683 4.31 81.8 µM 8.16E-5 SWF1 & branched chain AA biosynthesis 19 8.24E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.090 1.60E-7 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.085 7.46E-7 YJL139C YUR1 hom Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication
0.084 1.15E-6 YER078C ICP55 hom Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family
0.078 6.59E-6 YBL091C MAP2 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
0.076 1.03E-5 YIL076W SEC28 hom Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress
0.074 1.79E-5 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.074 1.95E-5 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.072 3.31E-5 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.071 4.35E-5 YPL193W RSA1 hom Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly
0.070 4.49E-5 YML112W CTK3 hom Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress
0.070 4.54E-5 YPR186C PZF1 het Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA
0.070 5.39E-5 YBR017C KAP104 hom Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis
0.069 5.79E-5 YDL075W RPL31A hom Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication
0.069 6.05E-5 YGR180C RNR4 hom Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.068 7.62E-5 YBR027C_d YBR027C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data