YPL098C / MGR2

Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL098C / MGR2

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:4.12|P-value:4.20E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.26|P-value:9.65E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.14|P-value:9.24E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-3.13|P-value:9.46E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.75|P-value:1.06E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.23|P-value:6.78E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-4.40|P-value:7.26E-6 ID:SGTC_493|Compound:zm226600|FD-Score:4.60|P-value:5.40E-6 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.37|P-value:4.22E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.38|P-value:6.46E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.67|P-value:2.31E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.19|P-value:7.76E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.84|P-value:1.22E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.37|P-value:6.58E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.19|P-value:7.94E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.59|P-value:3.15E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.70|P-value:2.06E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.29|P-value:8.84E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.69|P-value:2.13E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.39|P-value:6.24E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.44|P-value:5.35E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.36|P-value:4.37E-4 ID:SGTC_1696|Compound:st025591|FD-Score:5.29|P-value:2.01E-7 ID:SGTC_1700|Compound:st030840|FD-Score:4.69|P-value:3.48E-6 ID:SGTC_1708|Compound:st033234|FD-Score:3.48|P-value:4.59E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-3.63|P-value:1.67E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.29|P-value:8.58E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-4.13|P-value:2.35E-5 ID:SGTC_2048|Compound:5246248|FD-Score:-4.51|P-value:4.34E-6 ID:SGTC_2127|Compound:5253358|FD-Score:4.76|P-value:2.57E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:8.16|P-value:1.90E-15 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.97|P-value:4.38E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.71|P-value:3.24E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-4.95|P-value:5.63E-7 ID:SGTC_2860|Compound:9025725|FD-Score:5.07|P-value:5.93E-7 ID:SGTC_2912|Compound:7964298|FD-Score:-4.14|P-value:2.19E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.16|P-value:8.59E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.64|P-value:2.62E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_3224|Compound:9130643|FD-Score:-3.63|P-value:1.64E-4 ID:SGTC_3281|Compound:9140613|FD-Score:5.85|P-value:9.85E-9 ID:SGTC_26|Compound:0302-0163|FD-Score:4.12|P-value:4.20E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.26|P-value:9.65E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.14|P-value:9.24E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-3.13|P-value:9.46E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.75|P-value:1.06E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.23|P-value:6.78E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-4.40|P-value:7.26E-6 ID:SGTC_493|Compound:zm226600|FD-Score:4.60|P-value:5.40E-6 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.37|P-value:4.22E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.38|P-value:6.46E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.67|P-value:2.31E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.19|P-value:7.76E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.84|P-value:1.22E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.37|P-value:6.58E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.19|P-value:7.94E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.59|P-value:3.15E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.70|P-value:2.06E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.29|P-value:8.84E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.69|P-value:2.13E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.39|P-value:6.24E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.44|P-value:5.35E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.36|P-value:4.37E-4 ID:SGTC_1696|Compound:st025591|FD-Score:5.29|P-value:2.01E-7 ID:SGTC_1700|Compound:st030840|FD-Score:4.69|P-value:3.48E-6 ID:SGTC_1708|Compound:st033234|FD-Score:3.48|P-value:4.59E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-3.63|P-value:1.67E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.29|P-value:8.58E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-4.13|P-value:2.35E-5 ID:SGTC_2048|Compound:5246248|FD-Score:-4.51|P-value:4.34E-6 ID:SGTC_2127|Compound:5253358|FD-Score:4.76|P-value:2.57E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:8.16|P-value:1.90E-15 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.97|P-value:4.38E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.71|P-value:3.24E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-4.95|P-value:5.63E-7 ID:SGTC_2860|Compound:9025725|FD-Score:5.07|P-value:5.93E-7 ID:SGTC_2912|Compound:7964298|FD-Score:-4.14|P-value:2.19E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.16|P-value:8.59E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.64|P-value:2.62E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_3224|Compound:9130643|FD-Score:-3.63|P-value:1.64E-4 ID:SGTC_3281|Compound:9140613|FD-Score:5.85|P-value:9.85E-9

Top fitness defect scores for YPL098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2129 girgensonine 8.16 121.0 µM 1.90E-15 heme biosynthesis & mitochondrial translocase 4 1.65E-16
2 SGTC_3281 9140613 5.85 49.5 µM 9.85E-9 RPP1 & pyrimidine depletion 3 2.49E-9
3 SGTC_1696 st025591 5.29 34.8 µM 2.01E-7 SWF1 & branched chain AA biosynthesis 11 6.28E-8
4 SGTC_2860 9025725 5.07 39.0 µM 5.93E-7 RPP1 & pyrimidine depletion 2 2.00E-7
5 SGTC_2127 5253358 4.76 187.9 µM 2.57E-6 10 9.63E-7
6 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.71 66.7 µM 3.24E-6 5 1.23E-6
7 SGTC_1700 st030840 4.69 7.9 µM 3.48E-6 PDR1 13 1.34E-6
8 SGTC_493 zm226600 4.60 134.0 µM 5.40E-6 mitochondrial processes 7 2.14E-6
9 SGTC_3214 9129694 4.36 49.5 µM 1.52E-5 18 6.47E-6
10 SGTC_26 0302-0163 4.12 425.2 µM 4.20E-5 heme biosynthesis & mitochondrial translocase 3 1.93E-5
11 SGTC_936 3005-4620 3.84 401.0 µM 1.22E-4 23 6.08E-5
12 SGTC_1094 duloxetine 3.70 25.4 µM 2.06E-4 RPP1 & pyrimidine depletion 20 1.06E-4
13 SGTC_1605 st000082 3.69 49.1 µM 2.13E-4 60S ribosome export 24 1.10E-4
14 SGTC_695 3505-6186 3.67 243.0 µM 2.31E-4 32 1.20E-4
15 SGTC_3077 9117319 3.64 49.5 µM 2.62E-4 22 1.38E-4
16 SGTC_1049 3226-0134 3.59 66.0 µM 3.15E-4 43 1.67E-4
17 SGTC_1708 st033234 3.48 31.8 µM 4.59E-4 28 2.51E-4
18 SGTC_1677 st019204 3.44 53.9 µM 5.35E-4 37 2.96E-4
19 SGTC_1613 st002381 3.39 52.1 µM 6.24E-4 38 3.50E-4
20 SGTC_655 k060-0012 3.38 42.0 µM 6.46E-4 29 3.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.47E-10 YIL117C PRM5 hom Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
0.102 2.74E-9 YBR026C ETR1 hom 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis
0.100 7.06E-9 YMR258C ROY1 hom GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
0.097 2.05E-8 YAL044W-A_p YAL044W-A_p hom Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
0.081 3.01E-6 YOR361C PRT1 het eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
0.080 3.86E-6 YOR117W RPT5 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
0.076 9.53E-6 YOR120W GCY1 hom Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication
0.075 1.32E-5 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.075 1.55E-5 YPR164W MMS1 hom Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay
0.073 2.37E-5 YDL030W PRP9 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
0.073 2.38E-5 YBR005W RCR1 hom Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication
0.073 2.46E-5 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
0.068 7.32E-5 YNL225C CNM67 hom Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication
0.068 7.60E-5 YPR200C ARR2 hom Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p
0.068 8.37E-5 YDR477W SNF1 hom AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation