YPL100W / ATG21

Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL100W / ATG21

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.69|P-value:1.02E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:4.62|P-value:2.68E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.40|P-value:3.70E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.55|P-value:5.16E-11 ID:SGTC_352|Compound:k048-0007|FD-Score:4.18|P-value:1.91E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.29|P-value:5.58E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.40|P-value:4.15E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.38|P-value:8.00E-6 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.65|P-value:1.64E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.63|P-value:1.73E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.77|P-value:9.16E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:4.53|P-value:4.03E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:3.50|P-value:2.81E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.37|P-value:4.58E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.16|P-value:2.06E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.28|P-value:6.18E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.59|P-value:2.06E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.03|P-value:3.58E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:-4.51|P-value:3.90E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.20|P-value:1.78E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.59|P-value:2.02E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.15|P-value:2.21E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.15|P-value:2.14E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.25|P-value:6.88E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.25|P-value:6.87E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.52|P-value:2.43E-4 ID:SGTC_2012|Compound:4023501|FD-Score:6.84|P-value:7.40E-12 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.16|P-value:8.72E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.15|P-value:9.60E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-4.80|P-value:9.97E-7 ID:SGTC_2246|Compound:7293507|FD-Score:3.82|P-value:8.50E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.16|P-value:9.41E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.81|P-value:8.62E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.16|P-value:9.34E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.04|P-value:1.31E-9 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-10.90|P-value:2.36E-27 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.78|P-value:9.91E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.25|P-value:6.93E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.15|P-value:9.51E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.87|P-value:6.89E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.85|P-value:7.57E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.59|P-value:2.03E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.69|P-value:1.38E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.85|P-value:6.71E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.69|P-value:1.02E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:4.62|P-value:2.68E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.40|P-value:3.70E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.55|P-value:5.16E-11 ID:SGTC_352|Compound:k048-0007|FD-Score:4.18|P-value:1.91E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.29|P-value:5.58E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.40|P-value:4.15E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.38|P-value:8.00E-6 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.65|P-value:1.64E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.63|P-value:1.73E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.77|P-value:9.16E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:4.53|P-value:4.03E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:3.50|P-value:2.81E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.37|P-value:4.58E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.16|P-value:2.06E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.28|P-value:6.18E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.59|P-value:2.06E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.03|P-value:3.58E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:-4.51|P-value:3.90E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.20|P-value:1.78E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.59|P-value:2.02E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.15|P-value:2.21E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.15|P-value:2.14E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.25|P-value:6.88E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.25|P-value:6.87E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.52|P-value:2.43E-4 ID:SGTC_2012|Compound:4023501|FD-Score:6.84|P-value:7.40E-12 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.16|P-value:8.72E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.15|P-value:9.60E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-4.80|P-value:9.97E-7 ID:SGTC_2246|Compound:7293507|FD-Score:3.82|P-value:8.50E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.16|P-value:9.41E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.81|P-value:8.62E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.16|P-value:9.34E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.04|P-value:1.31E-9 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-10.90|P-value:2.36E-27 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.78|P-value:9.91E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.25|P-value:6.93E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.15|P-value:9.51E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.87|P-value:6.89E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.85|P-value:7.57E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.59|P-value:2.03E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.69|P-value:1.38E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.85|P-value:6.71E-5

Top fitness defect scores for YPL100W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2012 4023501 6.84 200.0 µM 7.40E-12 4 3.86E-12
2 SGTC_103 0844-0104 6.55 51.8 µM 5.16E-11 ERAD & cell cycle 66 2.83E-11
3 SGTC_2582 agaric acid 6.04 100.0 µM 1.31E-9 redox potentiating 159 7.81E-10
4 SGTC_58 0957-0393 5.69 9.0 µM 1.02E-8 cell wall 230 6.38E-9
5 SGTC_69 0096-0274 4.62 206.7 µM 2.68E-6 mitochondrial processes 27 1.94E-6
6 SGTC_740 k014-0057 4.53 261.0 µM 4.03E-6 13 2.95E-6
7 SGTC_462 ag-879 4.38 158.0 µM 8.00E-6 19 5.97E-6
8 SGTC_1333 1482-0047 4.20 286.0 µM 1.78E-5 12 1.35E-5
9 SGTC_352 k048-0007 4.18 5.1 µM 1.91E-5 ERAD & cell cycle 71 1.46E-5
10 SGTC_972 1319-0219 4.16 195.0 µM 2.06E-5 22 1.58E-5
11 SGTC_1508 1080-0625 4.15 72.9 µM 2.14E-5 13 1.64E-5
12 SGTC_1341 1486-1360 4.15 280.0 µM 2.21E-5 20 1.69E-5
13 SGTC_1222 0366-0074 4.03 1.2 µM 3.58E-5 TSC3-RPN4 12 2.77E-5
14 SGTC_2786 7743617 3.87 45.5 µM 6.89E-5 28 5.43E-5
15 SGTC_2849 9019321 3.85 13.0 µM 7.57E-5 34 5.98E-5
16 SGTC_2246 7293507 3.82 91.6 µM 8.50E-5 30 6.74E-5
17 SGTC_2466 5983409 3.81 37.1 µM 8.62E-5 21 6.83E-5
18 SGTC_2615 purpurogallin-4-carboxylic acid 3.78 100.0 µM 9.91E-5 redox potentiating 69 7.89E-5
19 SGTC_1754 st042065 3.73 16.1 µM 1.18E-4 NEO1-PIK1 198 9.43E-5
20 SGTC_3138 9097216 3.69 49.5 µM 1.38E-4 19 1.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.270 3.51E-57 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.235 2.93E-43 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.228 6.92E-41 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.208 3.14E-34 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.199 2.82E-31 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.178 3.19E-25 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.176 9.22E-25 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.169 5.61E-23 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.168 1.04E-22 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.165 6.95E-22 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.161 8.17E-21 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.160 1.10E-20 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.158 3.52E-20 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.157 7.55E-20 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.155 2.02E-19 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids