YPL101W / ELP4

Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL101W / ELP4

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.55|P-value:7.83E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.55|P-value:7.86E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.55|P-value:7.77E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.64|P-value:2.36E-7 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.48|P-value:8.46E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.21|P-value:8.86E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.76|P-value:1.08E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.83|P-value:6.79E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:3.83|P-value:3.21E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.64|P-value:5.98E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:7.86|P-value:1.09E-12 ID:SGTC_697|Compound:0508-1955|FD-Score:8.22|P-value:9.91E-14 ID:SGTC_699|Compound:0375-0592|FD-Score:-4.13|P-value:9.93E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:5.01|P-value:3.95E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.99|P-value:1.85E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.53|P-value:8.33E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-4.17|P-value:8.68E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.53|P-value:8.44E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.21|P-value:8.75E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.20|P-value:9.07E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.93|P-value:2.30E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.28|P-value:6.67E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.71|P-value:4.82E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.25|P-value:7.57E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.53|P-value:8.47E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.10|P-value:1.25E-23 ID:SGTC_1862|Compound:st057513|FD-Score:4.17|P-value:1.01E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.88|P-value:2.69E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.15|P-value:1.09E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.75|P-value:4.12E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.91|P-value:2.44E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.58|P-value:1.86E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-5.62|P-value:2.15E-7 ID:SGTC_2330|Compound:7979373|FD-Score:4.20|P-value:9.19E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.13|P-value:1.17E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.71|P-value:4.82E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.14|P-value:1.11E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.21|P-value:8.86E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.96|P-value:4.90E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-5.02|P-value:3.12E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.60|P-value:5.85E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.50|P-value:2.58E-21 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.98|P-value:4.40E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.73|P-value:3.86E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.83|P-value:3.23E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.90|P-value:6.17E-6 ID:SGTC_2827|Compound:7993847|FD-Score:5.33|P-value:9.97E-7 ID:SGTC_2877|Compound:9040724|FD-Score:-3.77|P-value:3.38E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.96|P-value:1.82E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.53|P-value:7.40E-4 ID:SGTC_3105|Compound:9121040|FD-Score:-3.56|P-value:6.67E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.55|P-value:7.83E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.55|P-value:7.86E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.55|P-value:7.77E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.64|P-value:2.36E-7 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.48|P-value:8.46E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.21|P-value:8.86E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.76|P-value:1.08E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.83|P-value:6.79E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:3.83|P-value:3.21E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.64|P-value:5.98E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:7.86|P-value:1.09E-12 ID:SGTC_697|Compound:0508-1955|FD-Score:8.22|P-value:9.91E-14 ID:SGTC_699|Compound:0375-0592|FD-Score:-4.13|P-value:9.93E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:5.01|P-value:3.95E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.99|P-value:1.85E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.53|P-value:8.33E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-4.17|P-value:8.68E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.53|P-value:8.44E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.21|P-value:8.75E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.20|P-value:9.07E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.93|P-value:2.30E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.28|P-value:6.67E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.71|P-value:4.82E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.25|P-value:7.57E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.53|P-value:8.47E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.10|P-value:1.25E-23 ID:SGTC_1862|Compound:st057513|FD-Score:4.17|P-value:1.01E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.88|P-value:2.69E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.15|P-value:1.09E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.75|P-value:4.12E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.91|P-value:2.44E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.58|P-value:1.86E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-5.62|P-value:2.15E-7 ID:SGTC_2330|Compound:7979373|FD-Score:4.20|P-value:9.19E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.13|P-value:1.17E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.71|P-value:4.82E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.14|P-value:1.11E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.21|P-value:8.86E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.96|P-value:4.90E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-5.02|P-value:3.12E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.60|P-value:5.85E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.50|P-value:2.58E-21 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.98|P-value:4.40E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.73|P-value:3.86E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.83|P-value:3.23E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.90|P-value:6.17E-6 ID:SGTC_2827|Compound:7993847|FD-Score:5.33|P-value:9.97E-7 ID:SGTC_2877|Compound:9040724|FD-Score:-3.77|P-value:3.38E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.96|P-value:1.82E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.53|P-value:7.40E-4 ID:SGTC_3105|Compound:9121040|FD-Score:-3.56|P-value:6.67E-4

Top fitness defect scores for YPL101W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 11.10 4.0 nM 1.25E-23 31 4.68E-29
2 SGTC_2679 rapamycin 10.50 1.0 nM 2.58E-21 23 3.58E-26
3 SGTC_697 0508-1955 8.22 564.0 µM 9.91E-14 2 9.87E-17
4 SGTC_694 1315-0438 7.86 43.2 µM 1.09E-12 1 1.95E-15
5 SGTC_258 haloperidol 5.64 50.8 µM 2.36E-7 fatty acid desaturase (OLE1) 10 8.34E-9
6 SGTC_2827 7993847 5.33 71.4 µM 9.97E-7 7 5.00E-8
7 SGTC_799 1310-0557 5.01 151.0 µM 3.95E-6 superoxide 9 2.76E-7
8 SGTC_2688 kanamycin b 4.98 96.7 µM 4.40E-6 calcium & mitochondrial duress 247 3.15E-7
9 SGTC_2582 agaric acid 4.96 100.0 µM 4.90E-6 redox potentiating 225 3.60E-7
10 SGTC_2810 7959871 4.90 45.5 µM 6.17E-6 copper-dependent oxidative stress 22 4.79E-7
11 SGTC_351 caspofungin 4.76 25.0 nM 1.08E-5 cell wall 61 9.54E-7
12 SGTC_1248 0469-0687 4.28 58.6 µM 6.67E-5 17 9.15E-6
13 SGTC_1578 josamycin 4.25 24.2 µM 7.57E-5 9 1.07E-5
14 SGTC_1147 3809-1045 4.21 12.3 µM 8.75E-5 17 1.28E-5
15 SGTC_317 4495-0002 4.21 170.0 µM 8.86E-5 7 1.30E-5
16 SGTC_2496 diffractaic acid 4.21 79.8 µM 8.86E-5 16 1.30E-5
17 SGTC_1195 1502-0147 4.20 41.1 µM 9.07E-5 19 1.34E-5
18 SGTC_2330 7979373 4.20 200.0 µM 9.19E-5 60S ribosome export 29 1.36E-5
19 SGTC_1862 st057513 4.17 3.8 µM 1.01E-4 7 1.53E-5
20 SGTC_1935 st074532 4.15 41.6 µM 1.09E-4 23 1.68E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.300 5.97E-71 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.283 6.55E-63 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.278 1.54E-60 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.274 1.01E-58 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.274 9.46E-59 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.258 4.69E-52 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.253 5.90E-50 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.227 2.20E-40 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.225 1.34E-39 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.222 8.45E-39 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.221 2.05E-38 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.210 7.63E-35 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.207 9.18E-34 YKR035W-A DID2 hom Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
0.203 1.05E-32 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.199 2.96E-31 YHR111W UBA4 hom Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p