YPL102C_d

Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL102C / YPL102C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.41|P-value:3.79E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-4.00|P-value:4.63E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:3.78|P-value:9.53E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.94|P-value:5.05E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:4.93|P-value:5.78E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.19|P-value:2.13E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.80|P-value:8.76E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.59|P-value:1.96E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.12|P-value:9.97E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.38|P-value:4.19E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.14|P-value:2.14E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.64|P-value:2.36E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:5.59|P-value:1.80E-8 ID:SGTC_806|Compound:3966-4455|FD-Score:3.33|P-value:4.97E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.77|P-value:1.29E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:-3.60|P-value:2.25E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.80|P-value:8.71E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:8.04|P-value:1.24E-15 ID:SGTC_901|Compound:1112-0062|FD-Score:3.18|P-value:8.26E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.36|P-value:5.27E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.44|P-value:3.97E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.54|P-value:2.34E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.53|P-value:3.95E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:4.04|P-value:3.37E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:6.62|P-value:3.52E-11 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.30|P-value:8.50E-8 ID:SGTC_1137|Compound:ixabepilone|FD-Score:7.99|P-value:1.82E-15 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.13|P-value:9.70E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.65|P-value:1.87E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.09|P-value:2.67E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.15|P-value:9.04E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.62|P-value:1.77E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:5.40|P-value:5.16E-8 ID:SGTC_1558|Compound:st069300|FD-Score:3.16|P-value:8.93E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.95|P-value:4.69E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.18|P-value:8.23E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.45|P-value:3.21E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.45|P-value:5.62E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.10|P-value:4.17E-28 ID:SGTC_1912|Compound:st060209|FD-Score:4.73|P-value:1.51E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-3.34|P-value:5.54E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.91|P-value:8.02E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:7.66|P-value:2.20E-14 ID:SGTC_1971|Compound:st069429|FD-Score:3.72|P-value:1.20E-4 ID:SGTC_2022|Compound:5136654|FD-Score:4.54|P-value:3.70E-6 ID:SGTC_2036|Compound:5160441|FD-Score:-3.28|P-value:6.84E-4 ID:SGTC_2037|Compound:5169046|FD-Score:-4.03|P-value:4.16E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.50|P-value:2.69E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.39|P-value:4.06E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.64|P-value:2.30E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.40|P-value:6.82E-17 ID:SGTC_2785|Compound:7756463|FD-Score:4.12|P-value:2.33E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.28|P-value:5.88E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.92|P-value:6.11E-7 ID:SGTC_3007|Compound:9078383|FD-Score:6.76|P-value:1.35E-11 ID:SGTC_3132|Compound:9126706|FD-Score:3.87|P-value:6.71E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.81|P-value:9.84E-5 ID:SGTC_3145|Compound:9085516|FD-Score:-3.29|P-value:6.75E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.32|P-value:5.06E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.55|P-value:3.55E-6 ID:SGTC_3242|Compound:9133940|FD-Score:3.25|P-value:6.66E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.41|P-value:6.81E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:3.41|P-value:3.79E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-4.00|P-value:4.63E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:3.78|P-value:9.53E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.94|P-value:5.05E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:4.93|P-value:5.78E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.19|P-value:2.13E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.80|P-value:8.76E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.59|P-value:1.96E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.12|P-value:9.97E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.38|P-value:4.19E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.14|P-value:2.14E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.64|P-value:2.36E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:5.59|P-value:1.80E-8 ID:SGTC_806|Compound:3966-4455|FD-Score:3.33|P-value:4.97E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.77|P-value:1.29E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:-3.60|P-value:2.25E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.80|P-value:8.71E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:8.04|P-value:1.24E-15 ID:SGTC_901|Compound:1112-0062|FD-Score:3.18|P-value:8.26E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.36|P-value:5.27E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.44|P-value:3.97E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.54|P-value:2.34E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.53|P-value:3.95E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:4.04|P-value:3.37E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:6.62|P-value:3.52E-11 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.30|P-value:8.50E-8 ID:SGTC_1137|Compound:ixabepilone|FD-Score:7.99|P-value:1.82E-15 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.13|P-value:9.70E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.65|P-value:1.87E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.09|P-value:2.67E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.15|P-value:9.04E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.62|P-value:1.77E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:5.40|P-value:5.16E-8 ID:SGTC_1558|Compound:st069300|FD-Score:3.16|P-value:8.93E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.95|P-value:4.69E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.18|P-value:8.23E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.45|P-value:3.21E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.45|P-value:5.62E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.10|P-value:4.17E-28 ID:SGTC_1912|Compound:st060209|FD-Score:4.73|P-value:1.51E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-3.34|P-value:5.54E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.91|P-value:8.02E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:7.66|P-value:2.20E-14 ID:SGTC_1971|Compound:st069429|FD-Score:3.72|P-value:1.20E-4 ID:SGTC_2022|Compound:5136654|FD-Score:4.54|P-value:3.70E-6 ID:SGTC_2036|Compound:5160441|FD-Score:-3.28|P-value:6.84E-4 ID:SGTC_2037|Compound:5169046|FD-Score:-4.03|P-value:4.16E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.50|P-value:2.69E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.39|P-value:4.06E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.64|P-value:2.30E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.40|P-value:6.82E-17 ID:SGTC_2785|Compound:7756463|FD-Score:4.12|P-value:2.33E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.28|P-value:5.88E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.92|P-value:6.11E-7 ID:SGTC_3007|Compound:9078383|FD-Score:6.76|P-value:1.35E-11 ID:SGTC_3132|Compound:9126706|FD-Score:3.87|P-value:6.71E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.81|P-value:9.84E-5 ID:SGTC_3145|Compound:9085516|FD-Score:-3.29|P-value:6.75E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.32|P-value:5.06E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.55|P-value:3.55E-6 ID:SGTC_3242|Compound:9133940|FD-Score:3.25|P-value:6.66E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.41|P-value:6.81E-6

Top fitness defect scores for YPL102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 11.10 4.0 nM 4.17E-28 32 5.77E-29
2 SGTC_2679 rapamycin 8.40 1.0 nM 6.82E-17 36 2.29E-17
3 SGTC_882 0843-0131 8.04 351.0 µM 1.24E-15 1 4.59E-16
4 SGTC_1137 ixabepilone 7.99 100.0 µM 1.82E-15 2 6.82E-16
5 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 7.66 70.1 µM 2.20E-14 2 9.00E-15
6 SGTC_3007 9078383 6.76 71.4 µM 1.35E-11 1 6.82E-12
7 SGTC_1126 isoteolin 6.62 1.0 µM 3.52E-11 4 1.84E-11
8 SGTC_800 3448-7362 5.59 155.0 µM 1.80E-8 translation 65 1.15E-8
9 SGTC_1557 sumaresinolic acid 5.40 42.3 µM 5.16E-8 3 3.41E-8
10 SGTC_1134 3477-0009 5.30 42.5 µM 8.50E-8 18 5.70E-8
11 SGTC_364 0083-0097 4.93 67.7 µM 5.78E-7 11 4.13E-7
12 SGTC_2978 9011784 4.92 43.0 µM 6.11E-7 13 4.37E-7
13 SGTC_864 0469-0573 4.77 172.0 µM 1.29E-6 6 9.41E-7
14 SGTC_1912 st060209 4.73 90.8 µM 1.51E-6 20 1.11E-6
15 SGTC_2582 agaric acid 4.64 100.0 µM 2.30E-6 redox potentiating 248 1.71E-6
16 SGTC_742 0kpi-0133 4.64 140.0 µM 2.36E-6 ERG2 9 1.76E-6
17 SGTC_3207 9114163 4.55 49.5 µM 3.55E-6 20 2.68E-6
18 SGTC_2022 5136654 4.54 200.0 µM 3.70E-6 12 2.79E-6
19 SGTC_1114 scopoletin 4.53 1.7 µM 3.95E-6 14 2.99E-6
20 SGTC_1818 st052136 4.45 56.3 µM 5.62E-6 NEO1-PIK1 32 4.30E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.303 2.65E-72 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.261 1.81E-53 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.254 1.61E-50 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.251 2.97E-49 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.248 3.51E-48 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.235 3.00E-43 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.234 7.46E-43 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.199 3.52E-31 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.193 1.70E-29 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.191 5.96E-29 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.190 1.21E-28 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.190 1.60E-28 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.185 4.26E-27 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.185 4.46E-27 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.184 5.26E-27 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity