YPL103C / FMP30

Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL103C / FMP30

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:4.52|P-value:1.82E-6 ID:SGTC_76|Compound:0433-0009|FD-Score:3.95|P-value:2.68E-5 ID:SGTC_229|Compound:benomyl|FD-Score:4.76|P-value:5.39E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:3.27|P-value:4.25E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.39|P-value:2.66E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.49|P-value:1.81E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.63|P-value:1.05E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.13|P-value:7.16E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.18|P-value:9.26E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:3.08|P-value:8.34E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.81|P-value:5.00E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.15|P-value:6.44E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.70|P-value:7.92E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.16|P-value:6.42E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.03|P-value:9.92E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.44|P-value:2.17E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.29|P-value:3.92E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.65|P-value:9.66E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.04|P-value:9.76E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-4.44|P-value:1.83E-6 ID:SGTC_2047|Compound:4141938|FD-Score:4.60|P-value:1.24E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.16|P-value:6.40E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.00|P-value:8.44E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.42|P-value:2.36E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.62|P-value:1.07E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.47|P-value:2.41E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.19|P-value:5.72E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.19|P-value:5.58E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.31|P-value:3.61E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.88|P-value:3.69E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-4.47|P-value:1.60E-6 ID:SGTC_2887|Compound:9044784|FD-Score:-3.03|P-value:7.70E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.73|P-value:6.33E-7 ID:SGTC_3203|Compound:9113543|FD-Score:4.16|P-value:1.03E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-3.72|P-value:5.27E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.03|P-value:9.95E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.39|P-value:1.96E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.24|P-value:4.74E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.38|P-value:2.76E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:4.52|P-value:1.82E-6 ID:SGTC_76|Compound:0433-0009|FD-Score:3.95|P-value:2.68E-5 ID:SGTC_229|Compound:benomyl|FD-Score:4.76|P-value:5.39E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:3.27|P-value:4.25E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.39|P-value:2.66E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.49|P-value:1.81E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.63|P-value:1.05E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.13|P-value:7.16E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.18|P-value:9.26E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:3.08|P-value:8.34E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.81|P-value:5.00E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.15|P-value:6.44E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.70|P-value:7.92E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.16|P-value:6.42E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.03|P-value:9.92E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.44|P-value:2.17E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.29|P-value:3.92E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.65|P-value:9.66E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.04|P-value:9.76E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-4.44|P-value:1.83E-6 ID:SGTC_2047|Compound:4141938|FD-Score:4.60|P-value:1.24E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.16|P-value:6.40E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.00|P-value:8.44E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.42|P-value:2.36E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.62|P-value:1.07E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.47|P-value:2.41E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.19|P-value:5.72E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.19|P-value:5.58E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.31|P-value:3.61E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.88|P-value:3.69E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-4.47|P-value:1.60E-6 ID:SGTC_2887|Compound:9044784|FD-Score:-3.03|P-value:7.70E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.73|P-value:6.33E-7 ID:SGTC_3203|Compound:9113543|FD-Score:4.16|P-value:1.03E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-3.72|P-value:5.27E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.03|P-value:9.95E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.39|P-value:1.96E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.24|P-value:4.74E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.38|P-value:2.76E-4

Top fitness defect scores for YPL103C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_229 benomyl 4.76 22.9 µM 5.39E-7 tubulin folding & SWR complex 22 9.67E-7
2 SGTC_3083 9117465 4.73 49.5 µM 6.33E-7 6 1.13E-6
3 SGTC_2047 4141938 4.60 200.0 µM 1.24E-6 1 2.13E-6
4 SGTC_23 0213-0011 4.52 40.0 µM 1.82E-6 copper-dependent oxidative stress 16 3.05E-6
5 SGTC_2420 aureobasidin a 4.47 50.0 nM 2.41E-6 29 3.99E-6
6 SGTC_602 3130-1533 4.18 38.1 µM 9.26E-6 14 1.43E-5
7 SGTC_3203 9113543 4.16 49.5 µM 1.03E-5 26 1.58E-5
8 SGTC_76 0433-0009 3.95 400.3 µM 2.68E-5 14 3.92E-5
9 SGTC_2768 sulfasalazine 3.88 50.2 µM 3.69E-5 17 5.30E-5
10 SGTC_1022 4477-0945 3.81 21.3 µM 5.00E-5 29 7.07E-5
11 SGTC_1142 3253-1408 3.70 9.8 µM 7.92E-5 16 1.09E-4
12 SGTC_1843 st055809 3.65 45.5 µM 9.66E-5 23 1.32E-4
13 SGTC_2586 curcumin 3.63 80.0 µM 1.04E-4 iron homeostasis 67 1.42E-4
14 SGTC_537 1334-0398 3.63 209.0 µM 1.05E-4 37 1.43E-4
15 SGTC_2377 9073351 3.62 62.6 µM 1.07E-4 ergosterol biosynthesis 30 1.46E-4
16 SGTC_396 dithiazanine 3.49 1.2 µM 1.81E-4 13 2.41E-4
17 SGTC_2625 euphol 3.46 100.0 µM 2.04E-4 47 2.69E-4
18 SGTC_1680 diphenhydramine 3.44 100.0 µM 2.17E-4 NEO1 47 2.86E-4
19 SGTC_2291 7917025 3.42 104.3 µM 2.36E-4 iron homeostasis 72 3.09E-4
20 SGTC_3214 9129694 3.40 49.5 µM 2.60E-4 43 3.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.82E-12 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.114 3.79E-11 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.113 4.38E-11 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.103 2.10E-9 YDR243C PRP28 het RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
0.096 2.92E-8 YOR353C SOG2 het Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
0.087 3.88E-7 YNL173C MDG1 hom Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
0.087 4.51E-7 YLR379W_d YLR379W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
0.085 9.46E-7 YNL254C RTC4 hom Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.079 4.25E-6 YKR094C RPL40B hom Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
0.078 6.19E-6 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.078 6.49E-6 YLR045C STU2 het Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
0.077 8.16E-6 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.077 8.48E-6 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.076 9.16E-6 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes
0.076 1.15E-5 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data