YPL105C / SYH1

Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL105C / SYH1

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:3.38|P-value:3.01E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.13|P-value:7.48E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.13|P-value:7.53E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.87|P-value:4.33E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.20|P-value:6.12E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.18|P-value:6.34E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.50|P-value:2.04E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.62|P-value:1.43E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.66|P-value:8.54E-12 ID:SGTC_794|Compound:k038-0031|FD-Score:3.80|P-value:5.90E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.71|P-value:9.46E-7 ID:SGTC_911|Compound:3456-4043|FD-Score:4.15|P-value:1.28E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:5.20|P-value:6.90E-8 ID:SGTC_980|Compound:1473-0395|FD-Score:3.24|P-value:5.04E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.16|P-value:6.82E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.29|P-value:4.18E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.04|P-value:2.12E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.79|P-value:6.42E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.78|P-value:6.27E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.06|P-value:1.93E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.43|P-value:2.51E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.60|P-value:1.30E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.71|P-value:8.39E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.57|P-value:1.49E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.89|P-value:3.99E-5 ID:SGTC_1812|Compound:st052057|FD-Score:3.58|P-value:1.42E-4 ID:SGTC_1820|Compound:st053765|FD-Score:-5.49|P-value:1.44E-8 ID:SGTC_1824|Compound:st053723|FD-Score:-3.63|P-value:1.23E-4 ID:SGTC_1906|Compound:st060206|FD-Score:-3.67|P-value:1.06E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.67|P-value:9.90E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.48|P-value:2.11E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.19|P-value:6.14E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.13|P-value:7.44E-4 ID:SGTC_2188|Compound:6126565|FD-Score:5.46|P-value:1.61E-8 ID:SGTC_2208|Compound:7283366|FD-Score:-3.91|P-value:3.83E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.76|P-value:6.79E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.08|P-value:8.88E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.48|P-value:2.08E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.99|P-value:2.67E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.20|P-value:1.11E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.97|P-value:2.37E-7 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.31|P-value:3.92E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.44|P-value:2.59E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.62|P-value:1.19E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.16|P-value:6.76E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-5.26|P-value:5.35E-8 ID:SGTC_2895|Compound:9054447|FD-Score:3.72|P-value:8.19E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.07|P-value:9.17E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.21|P-value:5.64E-4 ID:SGTC_3112|Compound:9123419|FD-Score:4.14|P-value:1.36E-5 ID:SGTC_3116|Compound:9124943|FD-Score:5.49|P-value:1.34E-8 ID:SGTC_3117|Compound:9124945|FD-Score:5.14|P-value:9.57E-8 ID:SGTC_3148|Compound:9097893|FD-Score:3.73|P-value:7.73E-5 ID:SGTC_3158|Compound:9100007|FD-Score:3.60|P-value:1.29E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.77|P-value:6.50E-5 ID:SGTC_3180|Compound:9109287|FD-Score:-3.29|P-value:4.52E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.38|P-value:3.01E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.13|P-value:7.48E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.13|P-value:7.53E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.87|P-value:4.33E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.20|P-value:6.12E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.18|P-value:6.34E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.50|P-value:2.04E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.62|P-value:1.43E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.66|P-value:8.54E-12 ID:SGTC_794|Compound:k038-0031|FD-Score:3.80|P-value:5.90E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.71|P-value:9.46E-7 ID:SGTC_911|Compound:3456-4043|FD-Score:4.15|P-value:1.28E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:5.20|P-value:6.90E-8 ID:SGTC_980|Compound:1473-0395|FD-Score:3.24|P-value:5.04E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.16|P-value:6.82E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.29|P-value:4.18E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.04|P-value:2.12E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.79|P-value:6.42E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.78|P-value:6.27E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.06|P-value:1.93E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.43|P-value:2.51E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.60|P-value:1.30E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.71|P-value:8.39E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.57|P-value:1.49E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.89|P-value:3.99E-5 ID:SGTC_1812|Compound:st052057|FD-Score:3.58|P-value:1.42E-4 ID:SGTC_1820|Compound:st053765|FD-Score:-5.49|P-value:1.44E-8 ID:SGTC_1824|Compound:st053723|FD-Score:-3.63|P-value:1.23E-4 ID:SGTC_1906|Compound:st060206|FD-Score:-3.67|P-value:1.06E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.67|P-value:9.90E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.48|P-value:2.11E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.19|P-value:6.14E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.13|P-value:7.44E-4 ID:SGTC_2188|Compound:6126565|FD-Score:5.46|P-value:1.61E-8 ID:SGTC_2208|Compound:7283366|FD-Score:-3.91|P-value:3.83E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.76|P-value:6.79E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.08|P-value:8.88E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.48|P-value:2.08E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.99|P-value:2.67E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.20|P-value:1.11E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.97|P-value:2.37E-7 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.31|P-value:3.92E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.44|P-value:2.59E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.62|P-value:1.19E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.16|P-value:6.76E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-5.26|P-value:5.35E-8 ID:SGTC_2895|Compound:9054447|FD-Score:3.72|P-value:8.19E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.07|P-value:9.17E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.21|P-value:5.64E-4 ID:SGTC_3112|Compound:9123419|FD-Score:4.14|P-value:1.36E-5 ID:SGTC_3116|Compound:9124943|FD-Score:5.49|P-value:1.34E-8 ID:SGTC_3117|Compound:9124945|FD-Score:5.14|P-value:9.57E-8 ID:SGTC_3148|Compound:9097893|FD-Score:3.73|P-value:7.73E-5 ID:SGTC_3158|Compound:9100007|FD-Score:3.60|P-value:1.29E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.77|P-value:6.50E-5 ID:SGTC_3180|Compound:9109287|FD-Score:-3.29|P-value:4.52E-4

Top fitness defect scores for YPL105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3116 9124943 5.49 49.5 µM 1.34E-8 4 2.04E-8
2 SGTC_2188 6126565 5.46 140.7 µM 1.61E-8 mitochondrial processes 2 2.43E-8
3 SGTC_963 1269-2853 5.20 151.0 µM 6.90E-8 11 1.01E-7
4 SGTC_3117 9124945 5.14 49.5 µM 9.57E-8 1 1.39E-7
5 SGTC_2578 7,8-dihydroxyflavone 4.97 64.4 µM 2.37E-7 16 3.37E-7
6 SGTC_747 3448-8087 4.62 38.7 µM 1.43E-6 14 1.95E-6
7 SGTC_911 3456-4043 4.15 236.0 µM 1.28E-5 mitochondrial processes 22 1.65E-5
8 SGTC_3112 9123419 4.14 49.5 µM 1.36E-5 RPP1 & pyrimidine depletion 7 1.75E-5
9 SGTC_1329 1447-1697 4.06 50.6 µM 1.93E-5 17 2.46E-5
10 SGTC_1092 toremifene 4.04 6.3 µM 2.12E-5 18 2.70E-5
11 SGTC_2513 baicalein 3.99 25.6 µM 2.67E-5 calcium & mitochondrial duress 27 3.37E-5
12 SGTC_1767 st044992 3.89 70.3 µM 3.99E-5 24 5.00E-5
13 SGTC_286 k060-0067 3.87 22.9 µM 4.33E-5 tubulin folding & SWR complex 27 5.41E-5
14 SGTC_794 k038-0031 3.80 316.0 µM 5.90E-5 ubiquinone biosynthesis & proteasome 114 7.33E-5
15 SGTC_1164 k060-0068 3.78 93.7 µM 6.27E-5 32 7.77E-5
16 SGTC_3179 9107801 3.77 49.5 µM 6.50E-5 11 8.05E-5
17 SGTC_2285 7945142 3.76 200.0 µM 6.79E-5 27 8.40E-5
18 SGTC_3148 9097893 3.73 49.5 µM 7.73E-5 43 9.53E-5
19 SGTC_2895 9054447 3.72 58.4 µM 8.19E-5 12 1.01E-4
20 SGTC_1647 st011722 3.71 22.4 µM 8.39E-5 11 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 1.55E-23 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.116 1.51E-11 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.114 3.56E-11 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.112 7.15E-11 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.109 2.14E-10 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.102 2.63E-9 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.100 7.04E-9 YDR242W AMD2 hom Putative amidase
0.097 2.09E-8 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.094 4.67E-8 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.093 7.99E-8 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.085 7.92E-7 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.080 3.30E-6 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.080 3.67E-6 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.079 4.42E-6 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.078 5.33E-6 YHR184W SSP1 hom Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis