YPL106C / SSE1

ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL106C / SSE1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.47|P-value:1.09E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.81|P-value:1.54E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.83|P-value:1.40E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.39|P-value:5.19E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.35|P-value:7.46E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.23|P-value:3.00E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.34|P-value:7.70E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:5.87|P-value:1.18E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.56|P-value:5.44E-6 ID:SGTC_259|Compound:usnic acid|FD-Score:4.54|P-value:7.99E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:4.48|P-value:1.04E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.64|P-value:2.14E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.41|P-value:6.11E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.28|P-value:2.44E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.32|P-value:2.02E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.30|P-value:8.96E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.13|P-value:4.53E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:5.52|P-value:7.47E-8 ID:SGTC_607|Compound:4491-0986|FD-Score:3.67|P-value:2.53E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.92|P-value:1.00E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.51|P-value:4.45E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.51|P-value:3.42E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.86|P-value:1.26E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.42|P-value:5.94E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.73|P-value:2.58E-8 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.67|P-value:1.91E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.02|P-value:6.86E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.45|P-value:1.20E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.57|P-value:7.09E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.38|P-value:6.84E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.40|P-value:6.32E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.29|P-value:7.16E-4 ID:SGTC_1571|Compound:st070080|FD-Score:4.12|P-value:4.60E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.28|P-value:9.39E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.54|P-value:3.92E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.28|P-value:7.57E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.62|P-value:3.04E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.58|P-value:2.64E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.62|P-value:5.71E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-4.40|P-value:1.06E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.62|P-value:2.27E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.28|P-value:9.40E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.75|P-value:1.87E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.80|P-value:1.58E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.72|P-value:3.70E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.36|P-value:7.23E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.41|P-value:6.21E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-3.25|P-value:8.35E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.81|P-value:1.16E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-5.79|P-value:1.22E-8 ID:SGTC_3214|Compound:9129694|FD-Score:6.37|P-value:6.48E-10 ID:SGTC_3219|Compound:9131112|FD-Score:-4.20|P-value:2.50E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.67|P-value:1.96E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.78|P-value:1.28E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.87|P-value:1.20E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.47|P-value:1.09E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.81|P-value:1.54E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.83|P-value:1.40E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.39|P-value:5.19E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.35|P-value:7.46E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.23|P-value:3.00E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.34|P-value:7.70E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:5.87|P-value:1.18E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.56|P-value:5.44E-6 ID:SGTC_259|Compound:usnic acid|FD-Score:4.54|P-value:7.99E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:4.48|P-value:1.04E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.64|P-value:2.14E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.41|P-value:6.11E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.28|P-value:2.44E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.32|P-value:2.02E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.30|P-value:8.96E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.13|P-value:4.53E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:5.52|P-value:7.47E-8 ID:SGTC_607|Compound:4491-0986|FD-Score:3.67|P-value:2.53E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.92|P-value:1.00E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.51|P-value:4.45E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.51|P-value:3.42E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.86|P-value:1.26E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.42|P-value:5.94E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.73|P-value:2.58E-8 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.67|P-value:1.91E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.02|P-value:6.86E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.45|P-value:1.20E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.57|P-value:7.09E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.38|P-value:6.84E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.40|P-value:6.32E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.29|P-value:7.16E-4 ID:SGTC_1571|Compound:st070080|FD-Score:4.12|P-value:4.60E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.28|P-value:9.39E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.54|P-value:3.92E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.28|P-value:7.57E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.62|P-value:3.04E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.58|P-value:2.64E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.62|P-value:5.71E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-4.40|P-value:1.06E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.62|P-value:2.27E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.28|P-value:9.40E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.75|P-value:1.87E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.80|P-value:1.58E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.72|P-value:3.70E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.36|P-value:7.23E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.41|P-value:6.21E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-3.25|P-value:8.35E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.81|P-value:1.16E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-5.79|P-value:1.22E-8 ID:SGTC_3214|Compound:9129694|FD-Score:6.37|P-value:6.48E-10 ID:SGTC_3219|Compound:9131112|FD-Score:-4.20|P-value:2.50E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.67|P-value:1.96E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.78|P-value:1.28E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.87|P-value:1.20E-4

Top fitness defect scores for YPL106C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3214 9129694 6.37 49.5 µM 6.48E-10 3 9.17E-11
2 SGTC_140 0062-0056 5.87 502.5 µM 1.18E-8 4 2.21E-9
3 SGTC_1032 k061-1018 5.73 98.7 µM 2.58E-8 4 5.17E-9
4 SGTC_596 1155-0152 5.52 116.0 µM 7.47E-8 TRP & mitochondrial translation 11 1.66E-8
5 SGTC_2804 7954240 4.72 19.5 µM 3.70E-6 18 1.19E-6
6 SGTC_2467 5474540 4.62 200.0 µM 5.71E-6 6 1.92E-6
7 SGTC_1173 0443-0020 4.57 122.0 µM 7.09E-6 TSC3-RPN4 23 2.42E-6
8 SGTC_259 usnic acid 4.54 108.9 µM 7.99E-6 8 2.76E-6
9 SGTC_301 4119-0100 4.48 24.5 µM 1.04E-5 NEO1 69 3.70E-6
10 SGTC_16 erodoxin 4.47 22.8 µM 1.09E-5 unfolded protein response 46 3.90E-6
11 SGTC_1171 0368-0077 4.45 21.4 µM 1.20E-5 15 4.30E-6
12 SGTC_449 xestospongin c 4.32 11.2 µM 2.02E-5 NEO1-PIK1 51 7.63E-6
13 SGTC_439 amiodarone 4.28 34.4 µM 2.44E-5 NEO1-PIK1 85 9.40E-6
14 SGTC_99 0109-0120 4.23 622.8 µM 3.00E-5 11 1.18E-5
15 SGTC_528 3492-0019 4.13 172.0 µM 4.53E-5 calcium & mitochondrial duress 205 1.85E-5
16 SGTC_1571 st070080 4.12 73.4 µM 4.60E-5 11 1.88E-5
17 SGTC_1160 4092-0570 4.02 10.5 µM 6.86E-5 plasma membrane duress 35 2.91E-5
18 SGTC_711 k292-0785 3.92 179.0 µM 1.00E-4 DNA intercalators 23 4.41E-5
19 SGTC_3314 9135860 3.87 59.4 µM 1.20E-4 19 5.36E-5
20 SGTC_795 0685-0265 3.86 78.0 µM 1.26E-4 excess fatty acid 30 5.67E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 4.18E-11 YDR200C VPS64 hom Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance
0.112 7.84E-11 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.107 4.84E-10 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.100 5.74E-9 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.100 6.70E-9 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.096 2.15E-8 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.089 2.54E-7 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.088 3.40E-7 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.086 5.60E-7 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.085 8.48E-7 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.085 8.64E-7 YKR016W FCJ1 hom Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane
0.082 2.26E-6 YIL133C RPL16A hom Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.078 6.42E-6 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.078 6.27E-6 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.078 6.35E-6 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact