YPL107W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL107W / YPL107W

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:-3.40|P-value:5.41E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.42|P-value:1.04E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.90|P-value:1.11E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.17|P-value:2.98E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.72|P-value:1.18E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-3.56|P-value:3.12E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.27|P-value:6.01E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.23|P-value:6.85E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.45|P-value:3.18E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.31|P-value:7.46E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.98|P-value:4.17E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.90|P-value:8.74E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-3.48|P-value:4.15E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.61|P-value:2.69E-6 ID:SGTC_1859|Compound:st055998|FD-Score:3.86|P-value:6.74E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.26|P-value:6.13E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.50|P-value:7.21E-6 ID:SGTC_1979|Compound:st071809|FD-Score:-3.40|P-value:5.51E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.26|P-value:1.28E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-5.56|P-value:3.79E-8 ID:SGTC_2282|Compound:7944268|FD-Score:3.41|P-value:3.60E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.12|P-value:2.39E-5 ID:SGTC_2307|Compound:7538926|FD-Score:3.50|P-value:2.68E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.23|P-value:9.79E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-5.24|P-value:2.05E-7 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.26|P-value:8.77E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.70|P-value:1.00E-8 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-4.49|P-value:7.64E-6 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.69|P-value:1.29E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.53|P-value:2.41E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.59|P-value:1.92E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.36|P-value:4.31E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.34|P-value:4.73E-4 ID:SGTC_2816|Compound:7982706|FD-Score:6.62|P-value:3.87E-11 ID:SGTC_2888|Compound:9058547|FD-Score:-3.76|P-value:1.51E-4 ID:SGTC_2890|Compound:9046729|FD-Score:-3.68|P-value:2.00E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.28|P-value:5.75E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.58|P-value:1.96E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.26|P-value:6.20E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.18|P-value:8.06E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.52|P-value:3.57E-4 ID:SGTC_3091|Compound:9116372|FD-Score:5.63|P-value:1.49E-8 ID:SGTC_3154|Compound:9100113|FD-Score:3.16|P-value:8.64E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.37|P-value:1.29E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-4.37|P-value:1.28E-5 ID:SGTC_3223|Compound:9129970|FD-Score:3.99|P-value:4.10E-5 ID:SGTC_3224|Compound:9130643|FD-Score:-3.84|P-value:1.12E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.23|P-value:9.83E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.40|P-value:5.41E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.42|P-value:1.04E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.90|P-value:1.11E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.17|P-value:2.98E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.72|P-value:1.18E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-3.56|P-value:3.12E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.27|P-value:6.01E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.23|P-value:6.85E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.45|P-value:3.18E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.31|P-value:7.46E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.98|P-value:4.17E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.90|P-value:8.74E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-3.48|P-value:4.15E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.61|P-value:2.69E-6 ID:SGTC_1859|Compound:st055998|FD-Score:3.86|P-value:6.74E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.26|P-value:6.13E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.50|P-value:7.21E-6 ID:SGTC_1979|Compound:st071809|FD-Score:-3.40|P-value:5.51E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.26|P-value:1.28E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-5.56|P-value:3.79E-8 ID:SGTC_2282|Compound:7944268|FD-Score:3.41|P-value:3.60E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.12|P-value:2.39E-5 ID:SGTC_2307|Compound:7538926|FD-Score:3.50|P-value:2.68E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.23|P-value:9.79E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-5.24|P-value:2.05E-7 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.26|P-value:8.77E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.70|P-value:1.00E-8 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-4.49|P-value:7.64E-6 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.69|P-value:1.29E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.53|P-value:2.41E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.59|P-value:1.92E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.36|P-value:4.31E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.34|P-value:4.73E-4 ID:SGTC_2816|Compound:7982706|FD-Score:6.62|P-value:3.87E-11 ID:SGTC_2888|Compound:9058547|FD-Score:-3.76|P-value:1.51E-4 ID:SGTC_2890|Compound:9046729|FD-Score:-3.68|P-value:2.00E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.28|P-value:5.75E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.58|P-value:1.96E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.26|P-value:6.20E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.18|P-value:8.06E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.52|P-value:3.57E-4 ID:SGTC_3091|Compound:9116372|FD-Score:5.63|P-value:1.49E-8 ID:SGTC_3154|Compound:9100113|FD-Score:3.16|P-value:8.64E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.37|P-value:1.29E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-4.37|P-value:1.28E-5 ID:SGTC_3223|Compound:9129970|FD-Score:3.99|P-value:4.10E-5 ID:SGTC_3224|Compound:9130643|FD-Score:-3.84|P-value:1.12E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.23|P-value:9.83E-4

Top fitness defect scores for YPL107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2816 7982706 6.62 58.4 µM 3.87E-11 azole & statin 13 1.83E-11
2 SGTC_2621 lithochol-11-enic acid 5.70 100.0 µM 1.00E-8 3 5.97E-9
3 SGTC_3091 9116372 5.63 49.5 µM 1.49E-8 4 9.02E-9
4 SGTC_1788 fluconazole 4.61 20.0 µM 2.69E-6 azole & statin 51 2.00E-6
5 SGTC_2268 7933382 4.26 153.8 µM 1.28E-5 33 1.01E-5
6 SGTC_2305 7443522 4.12 69.2 µM 2.39E-5 11 1.92E-5
7 SGTC_3223 9129970 3.99 49.5 µM 4.10E-5 23 3.37E-5
8 SGTC_1037 k284-1091 3.98 78.7 µM 4.17E-5 14 3.43E-5
9 SGTC_1859 st055998 3.86 20.0 µM 6.74E-5 26 5.64E-5
10 SGTC_774 k060-0086 3.72 136.0 µM 1.18E-4 22 1.01E-4
11 SGTC_2674 ligustilide 3.69 100.0 µM 1.29E-4 10 1.11E-4
12 SGTC_2760 etidronate 3.59 98.0 µM 1.92E-4 39 1.66E-4
13 SGTC_2897 9048598 3.58 13.0 µM 1.96E-4 23 1.70E-4
14 SGTC_2684 capsaicin 3.53 100.0 µM 2.41E-4 22 2.10E-4
15 SGTC_2307 7538926 3.50 6.3 µM 2.68E-4 58 2.36E-4
16 SGTC_971 1315-0384 3.45 26.7 µM 3.18E-4 cell wall signaling 43 2.81E-4
17 SGTC_2282 7944268 3.41 200.0 µM 3.60E-4 RPP1 & pyrimidine depletion 57 3.19E-4
18 SGTC_2791 5663188 3.36 71.4 µM 4.31E-4 RPP1 & pyrimidine depletion 43 3.85E-4
19 SGTC_2805 7950783 3.34 58.4 µM 4.73E-4 51 4.23E-4
20 SGTC_2896 9052656 3.28 71.4 µM 5.75E-4 endomembrane recycling 173 5.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.61E-16 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.139 5.37E-16 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.130 3.79E-14 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.114 4.17E-11 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.113 5.49E-11 YER053C PIC2 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.111 1.11E-10 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.108 3.28E-10 YLR203C MSS51 hom Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis
0.108 3.44E-10 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.108 3.81E-10 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.106 7.36E-10 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.103 2.36E-9 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.103 2.57E-9 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.102 2.99E-9 YKL174C TPO5 hom Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
0.099 1.00E-8 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.099 1.00E-8 YOR345C_d YOR345C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2