YPL108W_p

Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL108W / YPL108W

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:4.06|P-value:5.80E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.64|P-value:2.83E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.17|P-value:3.86E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.79|P-value:1.63E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.89|P-value:1.11E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.62|P-value:3.00E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.27|P-value:9.64E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.98|P-value:8.08E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.96|P-value:8.75E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.52|P-value:4.22E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.31|P-value:8.54E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.40|P-value:6.40E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.79|P-value:1.67E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.62|P-value:2.96E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.59|P-value:6.70E-6 ID:SGTC_1617|Compound:st002906|FD-Score:3.29|P-value:9.12E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-4.24|P-value:2.88E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.27|P-value:9.66E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-4.07|P-value:5.65E-5 ID:SGTC_1866|Compound:st057638|FD-Score:4.49|P-value:1.01E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.48|P-value:4.90E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.13|P-value:4.42E-5 ID:SGTC_2140|Compound:5586273|FD-Score:3.58|P-value:3.44E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.82|P-value:1.47E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-4.01|P-value:7.21E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.92|P-value:1.00E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.46|P-value:5.13E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.75|P-value:1.85E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.06|P-value:5.98E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.51|P-value:4.37E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.27|P-value:9.48E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.42|P-value:5.98E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.76|P-value:1.83E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.30|P-value:8.77E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.18|P-value:3.67E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.89|P-value:1.10E-4 ID:SGTC_3298|Compound:9116858|FD-Score:4.12|P-value:4.59E-5 ID:SGTC_3349|Compound:9149703|FD-Score:4.39|P-value:1.56E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:4.06|P-value:5.80E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.64|P-value:2.83E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.17|P-value:3.86E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.79|P-value:1.63E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.89|P-value:1.11E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.62|P-value:3.00E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.27|P-value:9.64E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.98|P-value:8.08E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.96|P-value:8.75E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.52|P-value:4.22E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.31|P-value:8.54E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.40|P-value:6.40E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.79|P-value:1.67E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.62|P-value:2.96E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.59|P-value:6.70E-6 ID:SGTC_1617|Compound:st002906|FD-Score:3.29|P-value:9.12E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-4.24|P-value:2.88E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.27|P-value:9.66E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-4.07|P-value:5.65E-5 ID:SGTC_1866|Compound:st057638|FD-Score:4.49|P-value:1.01E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.48|P-value:4.90E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.13|P-value:4.42E-5 ID:SGTC_2140|Compound:5586273|FD-Score:3.58|P-value:3.44E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.82|P-value:1.47E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-4.01|P-value:7.21E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.92|P-value:1.00E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.46|P-value:5.13E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.75|P-value:1.85E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.06|P-value:5.98E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.51|P-value:4.37E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.27|P-value:9.48E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.42|P-value:5.98E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.76|P-value:1.83E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.30|P-value:8.77E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.18|P-value:3.67E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.89|P-value:1.10E-4 ID:SGTC_3298|Compound:9116858|FD-Score:4.12|P-value:4.59E-5 ID:SGTC_3349|Compound:9149703|FD-Score:4.39|P-value:1.56E-5

Top fitness defect scores for YPL108W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 4.59 19.1 µM 6.70E-6 12 2.22E-6
2 SGTC_1866 st057638 4.49 64.0 µM 1.01E-5 9 3.50E-6
3 SGTC_3349 9149703 4.39 23.0 µM 1.56E-5 10 5.66E-6
4 SGTC_1999 st074831 4.13 12.5 µM 4.42E-5 plasma membrane duress 26 1.79E-5
5 SGTC_3298 9116858 4.12 71.4 µM 4.59E-5 7 1.86E-5
6 SGTC_11 0438-0307 4.06 1.3 µM 5.80E-5 8 2.42E-5
7 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.06 66.7 µM 5.98E-5 18 2.50E-5
8 SGTC_946 3434-1334 3.98 87.4 µM 8.08E-5 30 3.49E-5
9 SGTC_1023 4482-3888 3.96 16.0 µM 8.75E-5 TSC3-RPN4 17 3.81E-5
10 SGTC_2850 9015429 3.89 58.4 µM 1.10E-4 13 4.93E-5
11 SGTC_518 1021-0119 3.89 62.6 µM 1.11E-4 ERG2 43 4.97E-5
12 SGTC_2148 5546263 3.82 113.6 µM 1.47E-4 23 6.75E-5
13 SGTC_194 1486-1323 3.79 56.9 µM 1.63E-4 23 7.58E-5
14 SGTC_2552 juarezic acid 3.75 87.0 µM 1.85E-4 TSC3-RPN4 44 8.69E-5
15 SGTC_1592 4',5'-dihydroxyflavone 3.62 8.8 µM 2.96E-4 60S ribosome export 21 1.46E-4
16 SGTC_835 0312-0010 3.62 67.2 µM 3.00E-4 18 1.48E-4
17 SGTC_2140 5586273 3.58 200.0 µM 3.44E-4 RSC complex & mRNA processing 11 1.73E-4
18 SGTC_1040 k898-0338 3.52 155.0 µM 4.22E-4 31 2.16E-4
19 SGTC_2533 agelasine 3.46 13.7 µM 5.13E-4 ERG2 69 2.69E-4
20 SGTC_2802 7925815 3.42 54.5 µM 5.98E-4 61 3.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 6.04E-10 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.083 1.68E-6 YKL107W_p YKL107W_p hom Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein
0.073 2.60E-5 YPR089W_p YPR089W_p hom Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p
0.071 3.44E-5 YOR313C SPS4 hom Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
0.069 6.02E-5 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.066 1.20E-4 YOR239W ABP140 hom AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift
0.066 1.45E-4 YOR171C LCB4 hom Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
0.065 1.53E-4 YOL129W VPS68 hom Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
0.065 1.67E-4 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
0.064 2.14E-4 YER024W YAT2 hom Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
0.062 3.59E-4 YNL172W APC1 het Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
0.061 4.39E-4 YOR384W FRE5 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.060 4.98E-4 YKR088C TVP38 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.059 6.57E-4 YMR085W_p YMR085W_p hom Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.057 8.78E-4 YDR152W GIR2 hom Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein