Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YPL108W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.107 | 6.04E-10 | YDR032C | PST2 | hom | Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication |
0.083 | 1.68E-6 | YKL107W_p | YKL107W_p | hom | Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein |
0.073 | 2.60E-5 | YPR089W_p | YPR089W_p | hom | Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p |
0.071 | 3.44E-5 | YOR313C | SPS4 | hom | Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage |
0.069 | 6.02E-5 | YJL174W | KRE9 | het | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects |
0.066 | 1.20E-4 | YOR239W | ABP140 | hom | AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift |
0.066 | 1.45E-4 | YOR171C | LCB4 | hom | Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes |
0.065 | 1.53E-4 | YOL129W | VPS68 | hom | Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria |
0.065 | 1.67E-4 | YGR038W | ORM1 | hom | Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control |
0.064 | 2.14E-4 | YER024W | YAT2 | hom | Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane |
0.062 | 3.59E-4 | YNL172W | APC1 | het | Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress |
0.061 | 4.39E-4 | YOR384W | FRE5 | hom | Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.060 | 4.98E-4 | YKR088C | TVP38 | hom | Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern |
0.059 | 6.57E-4 | YMR085W_p | YMR085W_p | hom | Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 |
0.057 | 8.78E-4 | YDR152W | GIR2 | hom | Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein |