YPL109C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL109C / YPL109C

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-4.81|P-value:5.31E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.80|P-value:5.97E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:-4.40|P-value:4.09E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.63|P-value:1.22E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.53|P-value:2.22E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.18|P-value:6.60E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.24|P-value:4.11E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.04|P-value:1.63E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:4.08|P-value:1.34E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.63|P-value:1.23E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.67|P-value:1.03E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.58|P-value:1.13E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.51|P-value:1.48E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.08|P-value:9.32E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:5.33|P-value:2.12E-8 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.97|P-value:4.33E-10 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.30|P-value:3.38E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.41|P-value:2.21E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.34|P-value:2.90E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.20|P-value:6.15E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.21|P-value:5.83E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.18|P-value:5.10E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.08|P-value:7.42E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.03|P-value:8.64E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.12|P-value:6.50E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.42|P-value:2.77E-6 ID:SGTC_2244|Compound:6635614|FD-Score:-3.50|P-value:2.03E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.29|P-value:3.47E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.97|P-value:2.99E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.93|P-value:2.56E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.56|P-value:1.39E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-3.83|P-value:5.21E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-3.16|P-value:7.14E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.59|P-value:1.42E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-4.45|P-value:3.31E-6 ID:SGTC_2826|Compound:7992541|FD-Score:-4.94|P-value:2.76E-7 ID:SGTC_2922|Compound:7999257|FD-Score:3.11|P-value:6.58E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.66|P-value:8.17E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.05|P-value:8.27E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.20|P-value:4.84E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.81|P-value:5.31E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.80|P-value:5.97E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:-4.40|P-value:4.09E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.63|P-value:1.22E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.53|P-value:2.22E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.18|P-value:6.60E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.24|P-value:4.11E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.04|P-value:1.63E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:4.08|P-value:1.34E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.63|P-value:1.23E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.67|P-value:1.03E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.58|P-value:1.13E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.51|P-value:1.48E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.08|P-value:9.32E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:5.33|P-value:2.12E-8 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.97|P-value:4.33E-10 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.30|P-value:3.38E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.41|P-value:2.21E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.34|P-value:2.90E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.20|P-value:6.15E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.21|P-value:5.83E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.18|P-value:5.10E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.08|P-value:7.42E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.03|P-value:8.64E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.12|P-value:6.50E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.42|P-value:2.77E-6 ID:SGTC_2244|Compound:6635614|FD-Score:-3.50|P-value:2.03E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.29|P-value:3.47E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.97|P-value:2.99E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.93|P-value:2.56E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.56|P-value:1.39E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-3.83|P-value:5.21E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-3.16|P-value:7.14E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.59|P-value:1.42E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-4.45|P-value:3.31E-6 ID:SGTC_2826|Compound:7992541|FD-Score:-4.94|P-value:2.76E-7 ID:SGTC_2922|Compound:7999257|FD-Score:3.11|P-value:6.58E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.66|P-value:8.17E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.05|P-value:8.27E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.20|P-value:4.84E-4

Top fitness defect scores for YPL109C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1221 2958-7315 5.97 257.0 µM 4.33E-10 1 1.17E-9
2 SGTC_1216 1165-0504 5.33 9.7 µM 2.12E-8 2 4.82E-8
3 SGTC_2780 5215298 4.56 71.4 µM 1.39E-6 24 2.60E-6
4 SGTC_2068 5226020 4.42 147.0 µM 2.77E-6 21 5.04E-6
5 SGTC_527 4476-4215 4.08 268.0 µM 1.34E-5 PDR1 31 2.27E-5
6 SGTC_328 k915-0120 4.04 63.5 µM 1.63E-5 TSC3-RPN4 19 2.72E-5
7 SGTC_2466 5983409 3.93 37.1 µM 2.56E-5 18 4.21E-5
8 SGTC_2985 9022375 3.66 71.4 µM 8.17E-5 RPP1 & pyrimidine depletion 43 1.27E-4
9 SGTC_875 0709-0210 3.58 25.7 µM 1.13E-4 fatty acid desaturase (OLE1) 44 1.73E-4
10 SGTC_2488 5268135 3.52 45.7 µM 1.41E-4 70 2.14E-4
11 SGTC_1016 4226-1401 3.51 38.0 µM 1.48E-4 RNA pol III & RNase P/MRP 30 2.24E-4
12 SGTC_1345 1488-0192 3.41 31.4 µM 2.21E-4 27 3.27E-4
13 SGTC_1426 4048-4480 3.34 71.7 µM 2.90E-4 60S ribosome export 35 4.25E-4
14 SGTC_1296 1068-0102 3.30 11.9 µM 3.38E-4 19 4.92E-4
15 SGTC_2269 7935389 3.29 174.4 µM 3.47E-4 tubulin folding & SWR complex 47 5.04E-4
16 SGTC_282 k297-0036 3.24 65.7 µM 4.11E-4 10 5.93E-4
17 SGTC_3181 9108277 3.20 49.5 µM 4.84E-4 iron homeostasis 46 6.92E-4
18 SGTC_1935 st074532 3.18 41.6 µM 5.10E-4 69 7.27E-4
19 SGTC_1971 st069429 3.12 63.5 µM 6.50E-4 60S ribosome export 39 9.18E-4
20 SGTC_2922 7999257 3.11 32.5 µM 6.58E-4 31 9.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.27E-15 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.100 6.84E-9 YDL149W ATG9 hom Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
0.092 8.29E-8 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.088 3.10E-7 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.088 3.37E-7 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.088 3.46E-7 YLL061W MMP1 hom High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
0.087 5.14E-7 YOR334W MRS2 hom Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns
0.084 1.14E-6 YCR025C_d YCR025C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
0.083 1.66E-6 YMR047C NUP116 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
0.081 2.37E-6 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.081 2.90E-6 YGR060W ERG25 het C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.078 6.58E-6 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.077 7.13E-6 YDL184C RPL41A hom Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.077 7.90E-6 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.075 1.53E-5 YAR014C BUD14 hom Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress