YPL111W / CAR1

Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL111W / CAR1

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:3.28|P-value:7.29E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.25|P-value:7.09E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.62|P-value:1.93E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.63|P-value:2.17E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-4.20|P-value:1.88E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.49|P-value:3.09E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.79|P-value:1.18E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.13|P-value:2.57E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.77|P-value:1.27E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.73|P-value:1.48E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.95|P-value:7.75E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:3.61|P-value:2.36E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.76|P-value:1.33E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.32|P-value:6.46E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.47|P-value:3.90E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.37|P-value:5.37E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-3.50|P-value:2.97E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.17|P-value:2.60E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.37|P-value:5.46E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.18|P-value:2.48E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.81|P-value:1.10E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.62|P-value:2.20E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.60|P-value:2.39E-4 ID:SGTC_1819|Compound:st053448|FD-Score:5.48|P-value:5.06E-8 ID:SGTC_1822|Compound:st052468|FD-Score:4.13|P-value:3.07E-5 ID:SGTC_1825|Compound:st052143|FD-Score:-4.16|P-value:2.28E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-4.04|P-value:3.79E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.25|P-value:8.09E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.13|P-value:2.08E-12 ID:SGTC_2625|Compound:euphol|FD-Score:3.52|P-value:3.16E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.87|P-value:5.74E-9 ID:SGTC_2644|Compound:guaiazulene|FD-Score:-4.23|P-value:1.71E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.45|P-value:3.58E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:7.71|P-value:3.32E-14 ID:SGTC_3016|Compound:9080866|FD-Score:3.27|P-value:7.55E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.22|P-value:2.07E-5 ID:SGTC_3246|Compound:9135460|FD-Score:-3.70|P-value:1.42E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.28|P-value:7.29E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.25|P-value:7.09E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.62|P-value:1.93E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.63|P-value:2.17E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-4.20|P-value:1.88E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.49|P-value:3.09E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.79|P-value:1.18E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.13|P-value:2.57E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.77|P-value:1.27E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.73|P-value:1.48E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.95|P-value:7.75E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:3.61|P-value:2.36E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.76|P-value:1.33E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.32|P-value:6.46E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.47|P-value:3.90E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.37|P-value:5.37E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-3.50|P-value:2.97E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.17|P-value:2.60E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.37|P-value:5.46E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.18|P-value:2.48E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.81|P-value:1.10E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.62|P-value:2.20E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.60|P-value:2.39E-4 ID:SGTC_1819|Compound:st053448|FD-Score:5.48|P-value:5.06E-8 ID:SGTC_1822|Compound:st052468|FD-Score:4.13|P-value:3.07E-5 ID:SGTC_1825|Compound:st052143|FD-Score:-4.16|P-value:2.28E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-4.04|P-value:3.79E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.25|P-value:8.09E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.13|P-value:2.08E-12 ID:SGTC_2625|Compound:euphol|FD-Score:3.52|P-value:3.16E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.87|P-value:5.74E-9 ID:SGTC_2644|Compound:guaiazulene|FD-Score:-4.23|P-value:1.71E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.45|P-value:3.58E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:7.71|P-value:3.32E-14 ID:SGTC_3016|Compound:9080866|FD-Score:3.27|P-value:7.55E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.22|P-value:2.07E-5 ID:SGTC_3246|Compound:9135460|FD-Score:-3.70|P-value:1.42E-4

Top fitness defect scores for YPL111W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2758 dehydroepiandrosterone 7.71 69.3 µM 3.32E-14 15 6.53E-15
2 SGTC_2617 dihydrotanshinone i 7.13 20.8 µM 2.08E-12 copper-dependent oxidative stress 9 5.09E-13
3 SGTC_2627 acetyl isogambogic acid 5.87 100.0 µM 5.74E-9 TSC3-RPN4 14 2.15E-9
4 SGTC_1819 st053448 5.48 58.6 µM 5.06E-8 amide catabolism 4 2.13E-8
5 SGTC_686 1319-0111 4.95 510.0 µM 7.75E-7 60S ribosome export 10 3.76E-7
6 SGTC_3200 9114385 4.22 49.5 µM 2.07E-5 26 1.20E-5
7 SGTC_1390 3413-2614 4.18 145.0 µM 2.48E-5 fatty acid desaturase (OLE1) 22 1.45E-5
8 SGTC_1232 0279-0259 4.17 161.0 µM 2.60E-5 12 1.52E-5
9 SGTC_1822 st052468 4.13 42.0 µM 3.07E-5 9 1.81E-5
10 SGTC_1433 4060-0023 3.81 7.6 µM 1.10E-4 tubulin folding & SWR complex 22 6.93E-5
11 SGTC_590 k048-0076 3.79 22.4 µM 1.18E-4 RSC & ERG11 15 7.50E-5
12 SGTC_608 k048-0125 3.77 159.0 µM 1.27E-4 36 8.10E-5
13 SGTC_777 1315-0167 3.76 517.0 µM 1.33E-4 Golgi 32 8.48E-5
14 SGTC_685 1278-0033 3.73 54.9 µM 1.48E-4 60S ribosome export 28 9.50E-5
15 SGTC_494 Boc-Gly-Val-Val-CHO 3.63 140.0 µM 2.17E-4 13 1.43E-4
16 SGTC_1537 2',6'-dihydroxyflavanone 3.62 78.0 µM 2.20E-4 27 1.45E-4
17 SGTC_691 1548-0686 3.61 185.0 µM 2.36E-4 53 1.56E-4
18 SGTC_1551 6-bromo-3'-methylflavone 3.60 63.5 µM 2.39E-4 30 1.58E-4
19 SGTC_2625 euphol 3.52 100.0 µM 3.16E-4 40 2.12E-4
20 SGTC_892 0929-0076 3.47 29.0 µM 3.90E-4 TRP & mitochondrial translation 64 2.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.05E-14 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.110 2.01E-10 YJL026W RNR2 het Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
0.104 1.67E-9 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.097 1.76E-8 YHR181W SVP26 hom Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
0.096 2.62E-8 YPR121W THI22 hom Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
0.095 3.30E-8 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.51E-8 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.093 6.27E-8 YCL041C_d YCL041C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
0.092 8.65E-8 YNL282W POP3 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.085 7.29E-7 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.085 8.10E-7 YOR130C ORT1 hom Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
0.084 1.15E-6 YLR456W_p YLR456W_p hom Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication
0.083 1.29E-6 YER065C ICL1 hom Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
0.081 2.57E-6 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.074 1.61E-5 YGL117W_p YGL117W_p hom Putative protein of unknown function