YPL114W_d

Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL114W / YPL114W

Click on Significant Values for Screen Details ID:SGTC_79|Compound:0052-0007|FD-Score:3.18|P-value:6.36E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.53|P-value:2.31E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:3.33|P-value:3.67E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.78|P-value:6.56E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:4.66|P-value:1.19E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.17|P-value:7.63E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.23|P-value:9.44E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.06|P-value:2.02E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.42|P-value:2.61E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.17|P-value:6.65E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.48|P-value:2.53E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.98|P-value:3.41E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.16|P-value:8.06E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.45|P-value:2.40E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.26|P-value:4.81E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.07|P-value:9.15E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.24|P-value:6.01E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.23|P-value:6.21E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.53|P-value:1.77E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.28|P-value:4.36E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.15|P-value:7.01E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.88|P-value:4.21E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.17|P-value:1.24E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.58|P-value:1.46E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-4.27|P-value:9.63E-6 ID:SGTC_1757|Compound:st041620|FD-Score:-3.19|P-value:7.36E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.44|P-value:2.46E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.08|P-value:8.82E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.60|P-value:1.34E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.51|P-value:1.91E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.38|P-value:3.03E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.55|P-value:1.61E-4 ID:SGTC_2460|Compound:5552655|FD-Score:5.67|P-value:5.04E-9 ID:SGTC_2534|Compound:helenine|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.75|P-value:4.83E-12 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.35|P-value:6.76E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.23|P-value:5.35E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.34|P-value:3.52E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.26|P-value:4.76E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-4.65|P-value:1.65E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-3.42|P-value:3.20E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.37|P-value:3.23E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.18|P-value:6.36E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.53|P-value:2.31E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:3.33|P-value:3.67E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.78|P-value:6.56E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:4.66|P-value:1.19E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.17|P-value:7.63E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.23|P-value:9.44E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.06|P-value:2.02E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.42|P-value:2.61E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.17|P-value:6.65E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.48|P-value:2.53E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.98|P-value:3.41E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.16|P-value:8.06E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.45|P-value:2.40E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.26|P-value:4.81E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.07|P-value:9.15E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.24|P-value:6.01E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.23|P-value:6.21E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.53|P-value:1.77E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.28|P-value:4.36E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.15|P-value:7.01E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.88|P-value:4.21E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.17|P-value:1.24E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.58|P-value:1.46E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-4.27|P-value:9.63E-6 ID:SGTC_1757|Compound:st041620|FD-Score:-3.19|P-value:7.36E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.44|P-value:2.46E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.08|P-value:8.82E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.60|P-value:1.34E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.51|P-value:1.91E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.38|P-value:3.03E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.55|P-value:1.61E-4 ID:SGTC_2460|Compound:5552655|FD-Score:5.67|P-value:5.04E-9 ID:SGTC_2534|Compound:helenine|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.75|P-value:4.83E-12 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.35|P-value:6.76E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.23|P-value:5.35E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.34|P-value:3.52E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.26|P-value:4.76E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-4.65|P-value:1.65E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-3.42|P-value:3.20E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.37|P-value:3.23E-4

Top fitness defect scores for YPL114W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2581 avocatin a 6.75 64.0 µM 4.83E-12 sphingolipid biosynthesis & PDR1 12 7.64E-12
2 SGTC_2460 5552655 5.67 174.2 µM 5.04E-9 amide catabolism 11 7.16E-9
3 SGTC_164 4100-3994 4.66 89.6 µM 1.19E-6 15 1.54E-6
4 SGTC_88 0180-0332 4.53 8.7 µM 2.31E-6 13 2.97E-6
5 SGTC_439 amiodarone 4.23 34.4 µM 9.44E-6 NEO1-PIK1 86 1.18E-5
6 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 4.17 66.5 µM 1.24E-5 15 1.55E-5
7 SGTC_464 bw-b 70c 4.06 158.0 µM 2.02E-5 22 2.50E-5
8 SGTC_1392 3455-1037 3.88 33.9 µM 4.21E-5 17 5.14E-5
9 SGTC_159 3970-0959 3.78 50.0 µM 6.56E-5 84 7.96E-5
10 SGTC_920 mycophenolic acid 3.64 780.4 nM 1.13E-4 42 1.36E-4
11 SGTC_1967 st070177 3.60 51.4 µM 1.34E-4 23 1.60E-4
12 SGTC_2032 5185112 3.58 26.0 µM 1.41E-4 13 1.69E-4
13 SGTC_1650 st011916 3.58 45.8 µM 1.46E-4 19 1.75E-4
14 SGTC_2215 7188065 3.55 200.0 µM 1.61E-4 10 1.93E-4
15 SGTC_1106 tegaserod maleate 3.53 11.7 µM 1.77E-4 41 2.11E-4
16 SGTC_2172 5754775 3.51 163.9 µM 1.91E-4 27 2.27E-4
17 SGTC_913 3487-1245 3.45 167.0 µM 2.40E-4 52 2.85E-4
18 SGTC_1813 st051246 3.44 8.6 µM 2.46E-4 TSC3-RPN4 17 2.91E-4
19 SGTC_474 dl-dihydrosphingosine 3.42 5.0 µM 2.61E-4 51 3.09E-4
20 SGTC_2185 6113692 3.38 200.0 µM 3.03E-4 ergosterol biosynthesis 32 3.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.17E-14 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.109 2.88E-10 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.101 4.02E-9 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.094 4.96E-8 YJR008W MHO1 hom Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility
0.094 5.31E-8 YOL017W ESC8 hom Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
0.087 3.88E-7 YGR091W PRP31 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.085 8.80E-7 YDR288W NSE3 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
0.083 1.30E-6 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.083 1.35E-6 YNL031C HHT2 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
0.083 1.36E-6 YDL175C AIR2 hom RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication
0.083 1.42E-6 YOL086W-A MHF1 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.083 1.60E-6 YDR480W DIG2 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.083 1.62E-6 YJR044C VPS55 hom Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
0.080 3.67E-6 YBR015C MNN2 hom Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
0.079 4.03E-6 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans