YPL117C / IDI1

Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL117C / IDI1

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.15|P-value:4.73E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.34|P-value:2.24E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.73|P-value:4.36E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:3.02|P-value:7.47E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.63|P-value:6.70E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.22|P-value:4.63E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:10.20|P-value:5.78E-27 ID:SGTC_137|Compound:0438-0332|FD-Score:4.21|P-value:4.73E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.53|P-value:1.03E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.15|P-value:6.48E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.32|P-value:2.43E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.32|P-value:2.38E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.16|P-value:4.55E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.11|P-value:5.44E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-2.94|P-value:9.82E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.14|P-value:4.79E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.79|P-value:3.36E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:4.73|P-value:3.39E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.33|P-value:2.26E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.48|P-value:1.29E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.48|P-value:1.27E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.71|P-value:4.82E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.73|P-value:4.31E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.17|P-value:4.39E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.10|P-value:5.55E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.53|P-value:1.04E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.39|P-value:1.85E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.60|P-value:7.54E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.58|P-value:8.56E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.45|P-value:1.46E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.60|P-value:7.62E-5 ID:SGTC_1941|Compound:st076221|FD-Score:7.25|P-value:1.29E-14 ID:SGTC_1978|Compound:st071761|FD-Score:3.10|P-value:5.53E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.22|P-value:3.56E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.31|P-value:2.50E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-4.33|P-value:2.57E-6 ID:SGTC_2303|Compound:7774051|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.66|P-value:5.93E-5 ID:SGTC_2435|Compound:5706476|FD-Score:4.52|P-value:9.97E-7 ID:SGTC_2445|Compound:5742597|FD-Score:4.19|P-value:5.34E-6 ID:SGTC_2453|Compound:5731132|FD-Score:3.64|P-value:6.57E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.49|P-value:1.21E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.12|P-value:5.25E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.01|P-value:7.76E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.20|P-value:3.91E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.38|P-value:1.89E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-3.74|P-value:4.10E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.54|P-value:9.87E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.54|P-value:1.00E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.14|P-value:4.80E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.40|P-value:1.72E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.15|P-value:4.73E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.34|P-value:2.24E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.73|P-value:4.36E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:3.02|P-value:7.47E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.63|P-value:6.70E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.22|P-value:4.63E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:10.20|P-value:5.78E-27 ID:SGTC_137|Compound:0438-0332|FD-Score:4.21|P-value:4.73E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.53|P-value:1.03E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.15|P-value:6.48E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.32|P-value:2.43E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.32|P-value:2.38E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.16|P-value:4.55E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.11|P-value:5.44E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-2.94|P-value:9.82E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.14|P-value:4.79E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.79|P-value:3.36E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:4.73|P-value:3.39E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.33|P-value:2.26E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.48|P-value:1.29E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.48|P-value:1.27E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.71|P-value:4.82E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.73|P-value:4.31E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.17|P-value:4.39E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.10|P-value:5.55E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.53|P-value:1.04E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.39|P-value:1.85E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.60|P-value:7.54E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.58|P-value:8.56E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.45|P-value:1.46E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.60|P-value:7.62E-5 ID:SGTC_1941|Compound:st076221|FD-Score:7.25|P-value:1.29E-14 ID:SGTC_1978|Compound:st071761|FD-Score:3.10|P-value:5.53E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.22|P-value:3.56E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.31|P-value:2.50E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-4.33|P-value:2.57E-6 ID:SGTC_2303|Compound:7774051|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.66|P-value:5.93E-5 ID:SGTC_2435|Compound:5706476|FD-Score:4.52|P-value:9.97E-7 ID:SGTC_2445|Compound:5742597|FD-Score:4.19|P-value:5.34E-6 ID:SGTC_2453|Compound:5731132|FD-Score:3.64|P-value:6.57E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.49|P-value:1.21E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.12|P-value:5.25E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.01|P-value:7.76E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.20|P-value:3.91E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.38|P-value:1.89E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-3.74|P-value:4.10E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.54|P-value:9.87E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.54|P-value:1.00E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.14|P-value:4.80E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.40|P-value:1.72E-4

Top fitness defect scores for YPL117C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_103 0844-0104 10.20 51.8 µM 5.78E-27 ERAD & cell cycle 9 1.39E-24 0.51
2 SGTC_1941 st076221 7.25 61.8 µM 1.29E-14 sphingolipid biosynthesis & PDR1 1 2.13E-13 1.16
3 SGTC_948 3448-0295 4.73 75.3 µM 3.39E-7 6 1.14E-6 0.20
4 SGTC_2435 5706476 4.52 10.6 µM 9.97E-7 1 3.05E-6 0.78
5 SGTC_1161 k007-0610 4.48 110.0 µM 1.27E-6 ERAD & cell cycle 31 3.80E-6 0.00
6 SGTC_86 0417-1630 4.22 471.9 µM 4.63E-6 ubiquinone biosynthesis & proteasome 25 1.23E-5 0.04
7 SGTC_137 0438-0332 4.21 85.4 µM 4.73E-6 ubiquinone biosynthesis & proteasome 37 1.25E-5 0.02
8 SGTC_2445 5742597 4.19 35.6 µM 5.34E-6 5 1.40E-5 0.05
9 SGTC_217 ketoconazole 4.15 989.0 nM 6.48E-6 ergosterol depletion effects on membrane 11 1.67E-5 0.32
10 SGTC_2303 7774051 4.02 200.0 µM 1.21E-5 4 2.95E-5 0.17
11 SGTC_922 1866-0035 3.79 480.0 µM 3.36E-5 excess fatty acid 12 7.46E-5 0.32
12 SGTC_57 miconazole 3.73 162.5 nM 4.36E-5 ergosterol depletion effects on membrane 28 9.44E-5 0.21
13 SGTC_1204 4049-0315 3.71 18.3 µM 4.82E-5 12 1.04E-4 0.18
14 SGTC_2432 5630864 3.66 12.2 µM 5.93E-5 8 1.25E-4 0.00
15 SGTC_2453 5731132 3.64 22.2 µM 6.57E-5 8 1.37E-4 0.11
16 SGTC_84 0443-0269 3.63 128.8 µM 6.70E-5 3 1.40E-4 0.25
17 SGTC_1936 st074407 3.60 74.3 µM 7.62E-5 DNA damage response 15 1.57E-4 0.02
18 SGTC_1871 st057448 3.58 67.3 µM 8.56E-5 14 1.75E-4 0.22
19 SGTC_2935 9038016 3.54 30.0 µM 9.87E-5 10 1.99E-4 0.07
20 SGTC_3024 9090631 3.54 49.5 µM 1.00E-4 7 2.01E-4 0.56

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.306 1.70E-73 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.231 5.81E-42 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.218 2.68E-37 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.211 5.03E-35 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.193 1.47E-29 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.190 1.73E-28 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.186 2.07E-27 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.183 8.36E-27 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.182 2.31E-26 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.181 5.34E-26 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.180 7.52E-26 YKL020C SPT23 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.177 6.42E-25 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.174 3.48E-24 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.173 5.17E-24 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.173 7.69E-24 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19