YPL118W / MRP51

Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL118W / MRP51

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.59|P-value:8.15E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:3.37|P-value:7.83E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.63|P-value:3.36E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.31|P-value:1.46E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:10.30|P-value:1.22E-22 ID:SGTC_236|Compound:1509-0011|FD-Score:6.28|P-value:1.72E-9 ID:SGTC_251|Compound:melphalan|FD-Score:4.24|P-value:3.44E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.34|P-value:8.65E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.08|P-value:5.34E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:3.39|P-value:7.44E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.79|P-value:1.51E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.47|P-value:5.66E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:5.02|P-value:1.16E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:6.14|P-value:3.66E-9 ID:SGTC_735|Compound:3076-0345|FD-Score:4.22|P-value:3.74E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.34|P-value:8.66E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.42|P-value:6.79E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.36|P-value:8.06E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.43|P-value:6.58E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.97|P-value:9.42E-9 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.40|P-value:1.89E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.81|P-value:3.13E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:6.39|P-value:9.01E-10 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.21|P-value:3.80E-5 ID:SGTC_1642|Compound:st009582|FD-Score:-3.25|P-value:9.57E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.42|P-value:5.46E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.87|P-value:1.14E-4 ID:SGTC_1713|Compound:st033146|FD-Score:8.26|P-value:3.39E-15 ID:SGTC_1715|Compound:st032160|FD-Score:5.93|P-value:1.20E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.96|P-value:1.20E-6 ID:SGTC_1732|Compound:st034308|FD-Score:5.27|P-value:3.62E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.28|P-value:2.32E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.32|P-value:9.41E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.81|P-value:3.03E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.33|P-value:8.88E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.11|P-value:5.79E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.50|P-value:5.13E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.49|P-value:5.34E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.74|P-value:2.22E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.42|P-value:6.62E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.25|P-value:3.98E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.60|P-value:3.61E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.76|P-value:1.67E-4 ID:SGTC_2842|Compound:9000675|FD-Score:5.27|P-value:3.64E-7 ID:SGTC_2846|Compound:9008642|FD-Score:3.55|P-value:4.36E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.18|P-value:5.45E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-5.79|P-value:1.87E-8 ID:SGTC_2908|Compound:7930301|FD-Score:5.10|P-value:8.28E-7 ID:SGTC_2948|Compound:9070189|FD-Score:3.48|P-value:5.45E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.38|P-value:7.54E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.69|P-value:5.31E-6 ID:SGTC_3094|Compound:9117742|FD-Score:4.13|P-value:5.28E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.33|P-value:8.87E-4 ID:SGTC_3233|Compound:9132340|FD-Score:4.56|P-value:9.07E-6 ID:SGTC_3290|Compound:9121031|FD-Score:3.64|P-value:3.14E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.59|P-value:8.15E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:3.37|P-value:7.83E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.63|P-value:3.36E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.31|P-value:1.46E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:10.30|P-value:1.22E-22 ID:SGTC_236|Compound:1509-0011|FD-Score:6.28|P-value:1.72E-9 ID:SGTC_251|Compound:melphalan|FD-Score:4.24|P-value:3.44E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.34|P-value:8.65E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.08|P-value:5.34E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:3.39|P-value:7.44E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.79|P-value:1.51E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.47|P-value:5.66E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:5.02|P-value:1.16E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:6.14|P-value:3.66E-9 ID:SGTC_735|Compound:3076-0345|FD-Score:4.22|P-value:3.74E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.34|P-value:8.66E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.42|P-value:6.79E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.36|P-value:8.06E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.43|P-value:6.58E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.97|P-value:9.42E-9 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.40|P-value:1.89E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.81|P-value:3.13E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:6.39|P-value:9.01E-10 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.21|P-value:3.80E-5 ID:SGTC_1642|Compound:st009582|FD-Score:-3.25|P-value:9.57E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.42|P-value:5.46E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.87|P-value:1.14E-4 ID:SGTC_1713|Compound:st033146|FD-Score:8.26|P-value:3.39E-15 ID:SGTC_1715|Compound:st032160|FD-Score:5.93|P-value:1.20E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.96|P-value:1.20E-6 ID:SGTC_1732|Compound:st034308|FD-Score:5.27|P-value:3.62E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.28|P-value:2.32E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.32|P-value:9.41E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.81|P-value:3.03E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.33|P-value:8.88E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.11|P-value:5.79E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.50|P-value:5.13E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.49|P-value:5.34E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.74|P-value:2.22E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.42|P-value:6.62E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.25|P-value:3.98E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.60|P-value:3.61E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.76|P-value:1.67E-4 ID:SGTC_2842|Compound:9000675|FD-Score:5.27|P-value:3.64E-7 ID:SGTC_2846|Compound:9008642|FD-Score:3.55|P-value:4.36E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.18|P-value:5.45E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-5.79|P-value:1.87E-8 ID:SGTC_2908|Compound:7930301|FD-Score:5.10|P-value:8.28E-7 ID:SGTC_2948|Compound:9070189|FD-Score:3.48|P-value:5.45E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.38|P-value:7.54E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.69|P-value:5.31E-6 ID:SGTC_3094|Compound:9117742|FD-Score:4.13|P-value:5.28E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.33|P-value:8.87E-4 ID:SGTC_3233|Compound:9132340|FD-Score:4.56|P-value:9.07E-6 ID:SGTC_3290|Compound:9121031|FD-Score:3.64|P-value:3.14E-4

Top fitness defect scores for YPL118W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 10.30 2.7 µM 1.22E-22 mitochondrial stress 38 3.23E-25
2 SGTC_1713 st033146 8.26 12.8 µM 3.39E-15 1 7.00E-17
3 SGTC_1454 4239-0054 6.39 42.6 µM 9.01E-10 2 8.34E-11
4 SGTC_28 pentachloropyridine N-oxide 6.31 1.6 µM 1.46E-9 TSC3-RPN4 15 1.43E-10
5 SGTC_236 1509-0011 6.28 5.3 µM 1.72E-9 287 1.72E-10
6 SGTC_625 k213-0058 6.14 121.0 µM 3.66E-9 translation 32 4.00E-10
7 SGTC_275 trichlorophene 6.08 5.7 µM 5.34E-9 mitochondrial stress 114 6.12E-10
8 SGTC_1058 3448-5425 5.97 97.3 µM 9.42E-9 16 1.16E-9
9 SGTC_1715 st032160 5.93 10.2 µM 1.20E-8 17 1.52E-9
10 SGTC_1258 0671-0043 5.40 57.1 µM 1.89E-7 4 3.33E-8
11 SGTC_1732 st034308 5.27 51.8 µM 3.62E-7 9 6.88E-8
12 SGTC_2842 9000675 5.27 19.5 µM 3.64E-7 4 6.92E-8
13 SGTC_2526 patulin 5.25 37.6 µM 3.98E-7 42 7.65E-8
14 SGTC_2881 9058953 5.18 52.0 µM 5.45E-7 6 1.09E-7
15 SGTC_2908 7930301 5.10 100.0 µM 8.28E-7 8 1.74E-7
16 SGTC_420 mitomycin C 5.02 81.9 mM 1.16E-6 4 2.53E-7
17 SGTC_1964 st076914 4.81 61.0 µM 3.03E-6 RPP1 & pyrimidine depletion 7 7.43E-7
18 SGTC_1413 3910-0535 4.81 34.4 µM 3.13E-6 4 7.69E-7
19 SGTC_3074 9116018 4.69 49.5 µM 5.31E-6 RNA processing & uracil transport 10 1.39E-6
20 SGTC_10 0279-0212 4.59 42.6 µM 8.15E-6 TRP & mitochondrial translation 86 2.25E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.323 2.35E-82 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.312 1.66E-76 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.302 8.23E-72 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.300 1.39E-70 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.297 2.39E-69 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.291 1.56E-66 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.286 4.88E-64 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.283 1.24E-62 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.283 1.11E-62 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.280 1.46E-61 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.278 1.26E-60 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.277 2.53E-60 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.276 8.60E-60 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.272 3.91E-58 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.272 6.94E-58 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules