YPL122C / TFB2

Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL122C / TFB2

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:5.63|P-value:1.58E-8 ID:SGTC_110|Compound:0850-0284|FD-Score:3.53|P-value:2.68E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.44|P-value:3.38E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.45|P-value:4.37E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:3.99|P-value:4.43E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.46|P-value:3.45E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.75|P-value:1.53E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:3.51|P-value:2.90E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.55|P-value:3.50E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:4.07|P-value:3.17E-5 ID:SGTC_493|Compound:zm226600|FD-Score:4.13|P-value:2.53E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.09|P-value:2.49E-7 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.22|P-value:1.51E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.93|P-value:5.03E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.58|P-value:2.24E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.60|P-value:2.08E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.37|P-value:8.85E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.48|P-value:2.86E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.27|P-value:1.14E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:4.35|P-value:9.69E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.70|P-value:1.39E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.34|P-value:5.25E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.93|P-value:6.35E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.63|P-value:1.81E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.82|P-value:8.72E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.45|P-value:3.25E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.71|P-value:1.38E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.41|P-value:4.15E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.36|P-value:4.93E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.37|P-value:4.81E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.24|P-value:7.35E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.11|P-value:2.78E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.39|P-value:4.44E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.36|P-value:4.41E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-3.44|P-value:3.39E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.91|P-value:7.11E-7 ID:SGTC_2299|Compound:7976368|FD-Score:3.75|P-value:1.17E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.44|P-value:6.65E-6 ID:SGTC_2326|Compound:6164455|FD-Score:4.51|P-value:4.71E-6 ID:SGTC_2328|Compound:6201408|FD-Score:5.00|P-value:4.54E-7 ID:SGTC_2337|Compound:9009472|FD-Score:3.39|P-value:4.39E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.86|P-value:7.69E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:3.62|P-value:1.91E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.36|P-value:4.83E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.29|P-value:5.69E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.43|P-value:3.51E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.18|P-value:8.99E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.40|P-value:4.24E-4 ID:SGTC_2943|Compound:9068529|FD-Score:5.70|P-value:1.05E-8 ID:SGTC_3147|Compound:9097027|FD-Score:3.49|P-value:3.09E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.47|P-value:3.04E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.21|P-value:8.22E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.38|P-value:4.53E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.63|P-value:1.58E-8 ID:SGTC_110|Compound:0850-0284|FD-Score:3.53|P-value:2.68E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.44|P-value:3.38E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.45|P-value:4.37E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:3.99|P-value:4.43E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.46|P-value:3.45E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.75|P-value:1.53E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:3.51|P-value:2.90E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.55|P-value:3.50E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:4.07|P-value:3.17E-5 ID:SGTC_493|Compound:zm226600|FD-Score:4.13|P-value:2.53E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.09|P-value:2.49E-7 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.22|P-value:1.51E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.93|P-value:5.03E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.58|P-value:2.24E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.60|P-value:2.08E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.37|P-value:8.85E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.48|P-value:2.86E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.27|P-value:1.14E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:4.35|P-value:9.69E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.70|P-value:1.39E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.34|P-value:5.25E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.93|P-value:6.35E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.63|P-value:1.81E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.82|P-value:8.72E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.45|P-value:3.25E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.71|P-value:1.38E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.41|P-value:4.15E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.36|P-value:4.93E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.37|P-value:4.81E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.24|P-value:7.35E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.11|P-value:2.78E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.39|P-value:4.44E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.36|P-value:4.41E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-3.44|P-value:3.39E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.91|P-value:7.11E-7 ID:SGTC_2299|Compound:7976368|FD-Score:3.75|P-value:1.17E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.44|P-value:6.65E-6 ID:SGTC_2326|Compound:6164455|FD-Score:4.51|P-value:4.71E-6 ID:SGTC_2328|Compound:6201408|FD-Score:5.00|P-value:4.54E-7 ID:SGTC_2337|Compound:9009472|FD-Score:3.39|P-value:4.39E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.86|P-value:7.69E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:3.62|P-value:1.91E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.36|P-value:4.83E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.29|P-value:5.69E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.43|P-value:3.51E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.18|P-value:8.99E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.40|P-value:4.24E-4 ID:SGTC_2943|Compound:9068529|FD-Score:5.70|P-value:1.05E-8 ID:SGTC_3147|Compound:9097027|FD-Score:3.49|P-value:3.09E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.47|P-value:3.04E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.21|P-value:8.22E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.38|P-value:4.53E-4

Top fitness defect scores for YPL122C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2943 9068529 5.70 45.3 µM 1.05E-8 4 5.88E-9 0.08
2 SGTC_87 0100-0052 5.63 35.5 µM 1.58E-8 6 9.03E-9 0.00
3 SGTC_184 1494-0393 5.45 24.7 µM 4.37E-8 12 2.57E-8 0.09
4 SGTC_829 1635-0120 5.27 117.0 µM 1.14E-7 DNA damage response 32 6.93E-8 0.12
5 SGTC_2328 6201408 5.00 200.0 µM 4.54E-7 6 2.88E-7 0.46
6 SGTC_1105 epirubicin 4.93 18.1 µM 6.35E-7 anthracycline transcription coupled DNA repair 5 4.07E-7 0.28
7 SGTC_2099 5377090 4.91 177.4 µM 7.11E-7 2 4.58E-7 0.31
8 SGTC_287 k060-0039 4.75 29.6 µM 1.53E-6 5 1.01E-6 0.33
9 SGTC_2326 6164455 4.51 177.6 µM 4.71E-6 mitochondrial processes 9 3.22E-6 0.27
10 SGTC_2320 7373003 4.44 200.0 µM 6.65E-6 6 4.60E-6 0.05
11 SGTC_772 k072-0172 4.37 35.3 µM 8.85E-6 1 6.18E-6 0.35
12 SGTC_892 0929-0076 4.35 29.0 µM 9.69E-6 TRP & mitochondrial translation 4 6.78E-6 0.08
13 SGTC_493 zm226600 4.13 134.0 µM 2.53E-5 mitochondrial processes 2 1.83E-5 0.09
14 SGTC_1812 st052057 4.11 4.3 µM 2.78E-5 calcium & mitochondrial duress 6 2.01E-5 0.03
15 SGTC_366 0181-0206 4.07 4.3 µM 3.17E-5 Golgi 9 2.31E-5 0.05
16 SGTC_211 3455-0679 3.99 143.5 µM 4.43E-5 7 3.26E-5 0.68
17 SGTC_2552 juarezic acid 3.86 87.0 µM 7.69E-5 TSC3-RPN4 3 5.75E-5 0.43
18 SGTC_1265 0819-1001 3.82 68.8 µM 8.72E-5 9 6.56E-5 0.08
19 SGTC_2299 7976368 3.75 114.9 µM 1.17E-4 8 8.90E-5 0.02
20 SGTC_1467 k284-1082 3.71 293.0 µM 1.38E-4 7 1.05E-4 0.58

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.62E-9 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.100 6.53E-9 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.097 1.72E-8 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.097 1.77E-8 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.095 3.99E-8 YNL093W YPT53 hom Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication
0.093 6.18E-8 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.092 9.49E-8 YER093C TSC11 het Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
0.092 1.09E-7 YBR078W ECM33 hom GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
0.088 3.36E-7 YPL218W SAR1 het GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
0.085 9.16E-7 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.083 1.66E-6 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.082 2.03E-6 YOR318C_d YOR318C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
0.079 4.31E-6 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.078 6.39E-6 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.077 8.13E-6 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus