YPL123C / RNY1

Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL123C / RNY1

Click on Significant Values for Screen Details ID:SGTC_183|Compound:3914-0051|FD-Score:3.42|P-value:7.31E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.35|P-value:9.96E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:3.97|P-value:5.38E-6 ID:SGTC_337|Compound:1315-0038|FD-Score:2.93|P-value:5.70E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-2.98|P-value:4.71E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:2.83|P-value:8.56E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.50|P-value:5.19E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:2.83|P-value:8.46E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-2.85|P-value:7.97E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-5.27|P-value:2.42E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.37|P-value:6.03E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.31|P-value:1.22E-12 ID:SGTC_459|Compound:nigericin|FD-Score:5.24|P-value:3.01E-9 ID:SGTC_497|Compound:capsazepine|FD-Score:3.31|P-value:1.21E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.48|P-value:5.71E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.31|P-value:1.19E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.00|P-value:4.27E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.06|P-value:3.41E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:7.70|P-value:6.29E-18 ID:SGTC_941|Compound:3237-0776|FD-Score:3.46|P-value:6.21E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:10.20|P-value:2.99E-30 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.94|P-value:6.03E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-5.03|P-value:1.23E-8 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.68|P-value:1.03E-7 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.39|P-value:8.47E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:-3.95|P-value:5.97E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.43|P-value:7.00E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.32|P-value:1.14E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.07|P-value:3.35E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.03|P-value:3.91E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.11|P-value:2.79E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.05|P-value:3.63E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.08|P-value:3.10E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.39|P-value:8.43E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.37|P-value:9.20E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.29|P-value:1.30E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.36|P-value:9.58E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.35|P-value:1.02E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.86|P-value:9.40E-6 ID:SGTC_2783|Compound:7738165|FD-Score:-3.83|P-value:1.08E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.05|P-value:3.61E-4 ID:SGTC_2844|Compound:9010103|FD-Score:2.83|P-value:8.55E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.60|P-value:3.20E-5 ID:SGTC_2986|Compound:9022445|FD-Score:3.04|P-value:3.75E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.87|P-value:8.87E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-3.18|P-value:2.09E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-2.81|P-value:9.13E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.32|P-value:1.14E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-2.95|P-value:5.36E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.00|P-value:4.39E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.42|P-value:7.31E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.35|P-value:9.96E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:3.97|P-value:5.38E-6 ID:SGTC_337|Compound:1315-0038|FD-Score:2.93|P-value:5.70E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-2.98|P-value:4.71E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:2.83|P-value:8.56E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.50|P-value:5.19E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:2.83|P-value:8.46E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-2.85|P-value:7.97E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-5.27|P-value:2.42E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.37|P-value:6.03E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.31|P-value:1.22E-12 ID:SGTC_459|Compound:nigericin|FD-Score:5.24|P-value:3.01E-9 ID:SGTC_497|Compound:capsazepine|FD-Score:3.31|P-value:1.21E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.48|P-value:5.71E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.31|P-value:1.19E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.00|P-value:4.27E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.06|P-value:3.41E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:7.70|P-value:6.29E-18 ID:SGTC_941|Compound:3237-0776|FD-Score:3.46|P-value:6.21E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:10.20|P-value:2.99E-30 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.94|P-value:6.03E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-5.03|P-value:1.23E-8 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.68|P-value:1.03E-7 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.39|P-value:8.47E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:-3.95|P-value:5.97E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.43|P-value:7.00E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.32|P-value:1.14E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.07|P-value:3.35E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.03|P-value:3.91E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.11|P-value:2.79E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.05|P-value:3.63E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.08|P-value:3.10E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.39|P-value:8.43E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.37|P-value:9.20E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.29|P-value:1.30E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.36|P-value:9.58E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.35|P-value:1.02E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.86|P-value:9.40E-6 ID:SGTC_2783|Compound:7738165|FD-Score:-3.83|P-value:1.08E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.05|P-value:3.61E-4 ID:SGTC_2844|Compound:9010103|FD-Score:2.83|P-value:8.55E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.60|P-value:3.20E-5 ID:SGTC_2986|Compound:9022445|FD-Score:3.04|P-value:3.75E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.87|P-value:8.87E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-3.18|P-value:2.09E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-2.81|P-value:9.13E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.32|P-value:1.14E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-2.95|P-value:5.36E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.00|P-value:4.39E-4

Top fitness defect scores for YPL123C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_942 3253-1115 10.20 227.0 µM 2.99E-30 2 6.19E-25
2 SGTC_940 3232-1287 7.70 54.8 µM 6.29E-18 NEO1 5 6.65E-15
3 SGTC_457 grayanotoxin iii 6.31 135.0 µM 1.22E-12 19 1.36E-10
4 SGTC_459 nigericin 5.24 15.3 µM 3.01E-9 40 7.96E-8
5 SGTC_453 enantio-paf c16 4.37 10.0 µM 6.03E-7 114 6.07E-6
6 SGTC_312 4092-0653 3.97 6.8 µM 5.38E-6 ergosterol depletion effects on membrane 83 3.65E-5
7 SGTC_3149 9097855 3.87 49.5 µM 8.87E-6 Golgi 31 5.50E-5
8 SGTC_2770 toltrazuril 3.86 17.5 µM 9.40E-6 30 5.77E-5
9 SGTC_403 arphamenine a 3.50 50.0 µM 5.19E-5 60S ribosome export 26 2.34E-4
10 SGTC_941 3237-0776 3.46 460.0 µM 6.21E-5 33 2.72E-4
11 SGTC_1282 0886-0010 3.43 32.4 µM 7.00E-5 endomembrane recycling 51 3.00E-4
12 SGTC_183 3914-0051 3.42 30.6 µM 7.31E-5 60S ribosome export 38 3.11E-4
13 SGTC_2490 carminic acid 3.39 95.4 µM 8.43E-5 13 3.49E-4
14 SGTC_2592 piperlongumine 3.37 83.3 µM 9.20E-5 TSC3-RPN4 62 3.75E-4
15 SGTC_2763 lisinopril 3.36 49.3 µM 9.58E-5 19 3.88E-4
16 SGTC_310 1273-0058 3.35 1.1 µM 9.96E-5 mitochondrial stress 308 4.01E-4
17 SGTC_2764 methyldopa 3.35 94.7 µM 1.02E-4 36 4.09E-4
18 SGTC_3300 9124615 3.32 50.5 µM 1.14E-4 38 4.46E-4
19 SGTC_497 capsazepine 3.31 133.0 µM 1.21E-4 31 4.71E-4
20 SGTC_2315 7733312 3.08 200.0 µM 3.10E-4 54 0.00102

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.17E-19 YCR005C CIT2 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
0.140 3.69E-16 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.138 1.09E-15 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.132 1.67E-14 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
0.130 4.42E-14 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.128 1.08E-13 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.127 1.43E-13 YKL043W PHD1 hom Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication
0.126 2.34E-13 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.124 5.92E-13 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.123 7.47E-13 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.121 2.15E-12 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.117 1.30E-11 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.114 3.78E-11 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.112 8.49E-11 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.111 1.16E-10 YHR156C LIN1 hom Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication