HIPHOP chemogenomics database

YPL124W / SPC29

Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication

Zygosity: Heterozygous strain

fixedexpanded
Profile for YPL124W / SPC29

Click on Significant Values for Screen Details

Top fitness defect scores for YPL124W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_36	0335-0881	6.06	14.2 µM	1.26E-11	ubiquinone biosynthesis & proteasome	14	6.81E-10	0.07
2	SGTC_2584	androsterone	4.96	48.7 µM	2.20E-8	cell wall	20	3.44E-7	0.14
3	SGTC_1770	st043884	4.94	66.3 µM	2.55E-8		1	3.90E-7	0.63
4	SGTC_2567	aureobasidin a	4.84	60.0 nM	4.66E-8		29	6.43E-7	0.03
5	SGTC_86	0417-1630	4.47	471.9 µM	3.94E-7	ubiquinone biosynthesis & proteasome	21	3.82E-6	0.03
6	SGTC_1161	k007-0610	4.47	110.0 µM	4.01E-7	ERAD & cell cycle	32	3.88E-6	0.11
7	SGTC_137	0438-0332	4.39	85.4 µM	6.41E-7	ubiquinone biosynthesis & proteasome	34	5.74E-6	0.15
8	SGTC_1367	1812-0510	4.23	76.9 µM	1.47E-6		5	1.15E-5	0.11
9	SGTC_1260	0700-1617	4.21	7.8 µM	1.63E-6	calcium & mitochondrial duress	5	1.25E-5	0.03
10	SGTC_1880	MG-132	4.14	525.0 µM	2.42E-6		19	1.74E-5	0.17
11	SGTC_794	k038-0031	3.92	316.0 µM	7.43E-6	ubiquinone biosynthesis & proteasome	21	4.44E-5	0.09
12	SGTC_64	000l-0018	3.85	272.1 µM	1.02E-5	ubiquinone biosynthesis & proteasome	49	5.81E-5	0.06
13	SGTC_367	0335-0881	3.82	7.1 µM	1.24E-5	ubiquinone biosynthesis & proteasome	25	6.79E-5	0.08
14	SGTC_1296	1068-0102	3.78	11.9 µM	1.48E-5		1	7.91E-5	0.39
15	SGTC_103	0844-0104	3.48	51.8 µM	5.93E-5	ERAD & cell cycle	59	2.52E-4	0.03
16	SGTC_2329	6138490	3.43	200.0 µM	7.37E-5		18	3.02E-4	0.03
17	SGTC_1635	st007035	3.34	42.4 µM	1.08E-4		28	4.16E-4	0.06
18	SGTC_1314	1222-0010	3.27	41.1 µM	1.48E-4		6	5.42E-4	0.07
19	SGTC_514	4466-0038	3.25	2.6 nM	1.57E-4	cell wall	52	5.69E-4	0.05
20	SGTC_163	1327-0036	3.22	7.5 µM	1.79E-4		61	6.36E-4	0.01

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.352	1.52E-98	YER041W	YEN1	hom	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.339	4.79E-91	YDR537C_d	YDR537C_d	hom	Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.328	3.55E-85	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.322	1.27E-81	YPR146C_d	YPR146C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.311	4.11E-76	YJL193W_p	YJL193W_p	hom	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.303	2.52E-72	YNR041C	COQ2	hom	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.301	5.09E-71	YOR125C	CAT5	hom	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.299	4.96E-70	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.297	1.46E-69	YDR204W	COQ4	hom	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.293	2.75E-67	YJL155C	FBP26	hom	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.293	3.82E-67	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.283	8.32E-63	YJR129C_p	YJR129C_p	hom	Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.280	1.21E-61	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.277	3.68E-60	YMR067C	UBX4	hom	UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.275	2.01E-59	YGR255C	COQ6	hom	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)