YPL124W / SPC29

Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL124W / SPC29

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.06|P-value:1.26E-11 ID:SGTC_47|Compound:0149-0135|FD-Score:-2.89|P-value:9.12E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.85|P-value:1.02E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.47|P-value:3.94E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:3.48|P-value:5.93E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.39|P-value:6.41E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.22|P-value:1.79E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-2.93|P-value:7.98E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:2.96|P-value:5.23E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.82|P-value:1.24E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.32|P-value:1.43E-6 ID:SGTC_489|Compound:paxilline|FD-Score:2.90|P-value:6.52E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.25|P-value:1.57E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.92|P-value:7.43E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:2.79|P-value:9.86E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.33|P-value:1.62E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:2.91|P-value:6.19E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.11|P-value:3.88E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.47|P-value:4.01E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.00|P-value:6.05E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-2.99|P-value:6.20E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:2.98|P-value:4.71E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.21|P-value:1.63E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.21|P-value:2.60E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.78|P-value:1.48E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.27|P-value:1.48E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.23|P-value:1.47E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.82|P-value:8.83E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.01|P-value:4.20E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.28|P-value:1.94E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-3.04|P-value:5.26E-4 ID:SGTC_1768|Compound:st044301|FD-Score:2.92|P-value:5.99E-4 ID:SGTC_1770|Compound:st043884|FD-Score:4.94|P-value:2.55E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:4.14|P-value:2.42E-6 ID:SGTC_2022|Compound:5136654|FD-Score:2.95|P-value:5.45E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-2.92|P-value:8.31E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-2.95|P-value:7.35E-4 ID:SGTC_2197|Compound:6588183|FD-Score:-3.88|P-value:1.37E-5 ID:SGTC_2202|Compound:7226349|FD-Score:-2.91|P-value:8.39E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-2.93|P-value:7.79E-4 ID:SGTC_2295|Compound:7971645|FD-Score:2.96|P-value:5.14E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.43|P-value:7.37E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-2.97|P-value:6.82E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.56|P-value:5.91E-5 ID:SGTC_2335|Compound:9018011|FD-Score:2.85|P-value:7.83E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-2.91|P-value:8.67E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.84|P-value:4.66E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:2.83|P-value:8.32E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.96|P-value:2.20E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.01|P-value:4.25E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:2.92|P-value:6.09E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.06|P-value:1.26E-11 ID:SGTC_47|Compound:0149-0135|FD-Score:-2.89|P-value:9.12E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.85|P-value:1.02E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.47|P-value:3.94E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:3.48|P-value:5.93E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.39|P-value:6.41E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.22|P-value:1.79E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-2.93|P-value:7.98E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:2.96|P-value:5.23E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.82|P-value:1.24E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.32|P-value:1.43E-6 ID:SGTC_489|Compound:paxilline|FD-Score:2.90|P-value:6.52E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.25|P-value:1.57E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.92|P-value:7.43E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:2.79|P-value:9.86E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.33|P-value:1.62E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:2.91|P-value:6.19E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.11|P-value:3.88E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.47|P-value:4.01E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.00|P-value:6.05E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-2.99|P-value:6.20E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:2.98|P-value:4.71E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.21|P-value:1.63E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.21|P-value:2.60E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.78|P-value:1.48E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.27|P-value:1.48E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.23|P-value:1.47E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.82|P-value:8.83E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.01|P-value:4.20E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.28|P-value:1.94E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-3.04|P-value:5.26E-4 ID:SGTC_1768|Compound:st044301|FD-Score:2.92|P-value:5.99E-4 ID:SGTC_1770|Compound:st043884|FD-Score:4.94|P-value:2.55E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:4.14|P-value:2.42E-6 ID:SGTC_2022|Compound:5136654|FD-Score:2.95|P-value:5.45E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-2.92|P-value:8.31E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-2.95|P-value:7.35E-4 ID:SGTC_2197|Compound:6588183|FD-Score:-3.88|P-value:1.37E-5 ID:SGTC_2202|Compound:7226349|FD-Score:-2.91|P-value:8.39E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-2.93|P-value:7.79E-4 ID:SGTC_2295|Compound:7971645|FD-Score:2.96|P-value:5.14E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.43|P-value:7.37E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-2.97|P-value:6.82E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.56|P-value:5.91E-5 ID:SGTC_2335|Compound:9018011|FD-Score:2.85|P-value:7.83E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-2.91|P-value:8.67E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.84|P-value:4.66E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:2.83|P-value:8.32E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.96|P-value:2.20E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.01|P-value:4.25E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:2.92|P-value:6.09E-4

Top fitness defect scores for YPL124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_36 0335-0881 6.06 14.2 µM 1.26E-11 ubiquinone biosynthesis & proteasome 14 6.81E-10 0.07
2 SGTC_2584 androsterone 4.96 48.7 µM 2.20E-8 cell wall 20 3.44E-7 0.14
3 SGTC_1770 st043884 4.94 66.3 µM 2.55E-8 1 3.90E-7 0.63
4 SGTC_2567 aureobasidin a 4.84 60.0 nM 4.66E-8 29 6.43E-7 0.03
5 SGTC_86 0417-1630 4.47 471.9 µM 3.94E-7 ubiquinone biosynthesis & proteasome 21 3.82E-6 0.03
6 SGTC_1161 k007-0610 4.47 110.0 µM 4.01E-7 ERAD & cell cycle 32 3.88E-6 0.11
7 SGTC_137 0438-0332 4.39 85.4 µM 6.41E-7 ubiquinone biosynthesis & proteasome 34 5.74E-6 0.15
8 SGTC_1367 1812-0510 4.23 76.9 µM 1.47E-6 5 1.15E-5 0.11
9 SGTC_1260 0700-1617 4.21 7.8 µM 1.63E-6 calcium & mitochondrial duress 5 1.25E-5 0.03
10 SGTC_1880 MG-132 4.14 525.0 µM 2.42E-6 19 1.74E-5 0.17
11 SGTC_794 k038-0031 3.92 316.0 µM 7.43E-6 ubiquinone biosynthesis & proteasome 21 4.44E-5 0.09
12 SGTC_64 000l-0018 3.85 272.1 µM 1.02E-5 ubiquinone biosynthesis & proteasome 49 5.81E-5 0.06
13 SGTC_367 0335-0881 3.82 7.1 µM 1.24E-5 ubiquinone biosynthesis & proteasome 25 6.79E-5 0.08
14 SGTC_1296 1068-0102 3.78 11.9 µM 1.48E-5 1 7.91E-5 0.39
15 SGTC_103 0844-0104 3.48 51.8 µM 5.93E-5 ERAD & cell cycle 59 2.52E-4 0.03
16 SGTC_2329 6138490 3.43 200.0 µM 7.37E-5 18 3.02E-4 0.03
17 SGTC_1635 st007035 3.34 42.4 µM 1.08E-4 28 4.16E-4 0.06
18 SGTC_1314 1222-0010 3.27 41.1 µM 1.48E-4 6 5.42E-4 0.07
19 SGTC_514 4466-0038 3.25 2.6 nM 1.57E-4 cell wall 52 5.69E-4 0.05
20 SGTC_163 1327-0036 3.22 7.5 µM 1.79E-4 61 6.36E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.352 1.52E-98 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.339 4.79E-91 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.328 3.55E-85 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.322 1.27E-81 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.311 4.11E-76 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.303 2.52E-72 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.301 5.09E-71 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.299 4.96E-70 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.297 1.46E-69 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.293 2.75E-67 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.293 3.82E-67 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.283 8.32E-63 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.280 1.21E-61 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.277 3.68E-60 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.275 2.01E-59 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)