YPL126W / NAN1

U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL126W / NAN1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:5.25|P-value:1.88E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.45|P-value:1.79E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.72|P-value:3.69E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:3.76|P-value:3.94E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.13|P-value:6.05E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.64|P-value:5.54E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:4.42|P-value:1.73E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:2.95|P-value:9.48E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.31|P-value:3.05E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.43|P-value:1.96E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.05|P-value:6.73E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.29|P-value:3.32E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.56|P-value:9.03E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.78|P-value:3.59E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.12|P-value:5.11E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.22|P-value:4.72E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:3.13|P-value:4.93E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.02|P-value:7.45E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.44|P-value:1.60E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.82|P-value:3.02E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.24|P-value:4.38E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.58|P-value:8.55E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.02|P-value:1.24E-5 ID:SGTC_1526|Compound:st051518|FD-Score:-4.42|P-value:2.32E-6 ID:SGTC_1611|Compound:st001856|FD-Score:3.17|P-value:4.36E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.13|P-value:6.17E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.04|P-value:8.46E-8 ID:SGTC_1800|Compound:st050079|FD-Score:4.22|P-value:4.67E-6 ID:SGTC_1886|Compound:st057356|FD-Score:2.94|P-value:9.73E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.31|P-value:2.55E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.44|P-value:1.87E-4 ID:SGTC_2063|Compound:5246145|FD-Score:2.97|P-value:8.90E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.42|P-value:1.61E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.43|P-value:1.90E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.97|P-value:1.99E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.79|P-value:3.47E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:5.25|P-value:1.88E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.45|P-value:1.79E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.72|P-value:3.69E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:3.76|P-value:3.94E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.13|P-value:6.05E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.64|P-value:5.54E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:4.42|P-value:1.73E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:2.95|P-value:9.48E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.31|P-value:3.05E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.43|P-value:1.96E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.05|P-value:6.73E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.29|P-value:3.32E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.56|P-value:9.03E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.78|P-value:3.59E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.12|P-value:5.11E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.22|P-value:4.72E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:3.13|P-value:4.93E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.02|P-value:7.45E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.44|P-value:1.60E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.82|P-value:3.02E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.24|P-value:4.38E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.58|P-value:8.55E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.02|P-value:1.24E-5 ID:SGTC_1526|Compound:st051518|FD-Score:-4.42|P-value:2.32E-6 ID:SGTC_1611|Compound:st001856|FD-Score:3.17|P-value:4.36E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.13|P-value:6.17E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.04|P-value:8.46E-8 ID:SGTC_1800|Compound:st050079|FD-Score:4.22|P-value:4.67E-6 ID:SGTC_1886|Compound:st057356|FD-Score:2.94|P-value:9.73E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.31|P-value:2.55E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.44|P-value:1.87E-4 ID:SGTC_2063|Compound:5246145|FD-Score:2.97|P-value:8.90E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.42|P-value:1.61E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.43|P-value:1.90E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.97|P-value:1.99E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.79|P-value:3.47E-5

Top fitness defect scores for YPL126W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_36 0335-0881 5.25 14.2 µM 1.88E-8 ubiquinone biosynthesis & proteasome 21 7.63E-8 0.18
2 SGTC_67 0335-0847 4.72 266.0 µM 3.69E-7 ubiquinone biosynthesis & proteasome 13 1.17E-6 0.26
3 SGTC_137 0438-0332 4.64 85.4 µM 5.54E-7 ubiquinone biosynthesis & proteasome 31 1.70E-6 0.13
4 SGTC_1158 4092-0494 4.44 91.8 µM 1.60E-6 2 4.49E-6 0.40
5 SGTC_142 0335-0849 4.42 62.7 µM 1.73E-6 ubiquinone biosynthesis & proteasome 15 4.84E-6 0.33
6 SGTC_1232 0279-0259 4.24 161.0 µM 4.38E-6 2 1.13E-5 0.26
7 SGTC_1800 st050079 4.22 29.1 µM 4.67E-6 NEO1-PIK1 23 1.20E-5 0.09
8 SGTC_817 1391-0715 4.22 46.0 µM 4.72E-6 5 1.21E-5 0.14
9 SGTC_1338 1486-1223 4.02 76.0 µM 1.24E-5 1 2.96E-5 0.35
10 SGTC_1161 k007-0610 3.82 110.0 µM 3.02E-5 ERAD & cell cycle 44 6.68E-5 0.28
11 SGTC_2651 1327-0036 3.79 5.0 µM 3.47E-5 50 7.59E-5 0.01
12 SGTC_635 k038-0028 3.78 24.7 µM 3.59E-5 ubiquinone biosynthesis & proteasome 18 7.81E-5 0.06
13 SGTC_103 0844-0104 3.76 51.8 µM 3.94E-5 ERAD & cell cycle 51 8.52E-5 0.02
14 SGTC_1248 0469-0687 3.58 58.6 µM 8.55E-5 10 1.73E-4 0.10
15 SGTC_608 k048-0125 3.56 159.0 µM 9.03E-5 8 1.82E-4 0.09
16 SGTC_2331 7980721 3.42 200.0 µM 1.61E-4 18 3.09E-4 0.13
17 SGTC_1923 st058458 3.31 19.1 µM 2.55E-4 16 4.72E-4 0.05
18 SGTC_1611 st001856 3.17 99.4 µM 4.36E-4 21 7.74E-4 0.25
19 SGTC_837 0091-0265 3.13 12.5 µM 4.93E-4 ubiquinone biosynthesis & proteasome 19 8.66E-4 0.04
20 SGTC_737 1950-0117 3.12 57.9 µM 5.11E-4 13 8.95E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.280 2.85E-61 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.256 3.64E-51 YPL153C RAD53 het Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
0.251 2.28E-49 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.249 1.02E-48 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.247 8.60E-48 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.246 1.81E-47 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.246 2.55E-47 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.245 3.10E-47 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.240 2.32E-45 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.235 1.92E-43 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.233 1.94E-42 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.230 2.38E-41 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.226 4.36E-40 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.214 5.47E-36 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.207 9.15E-34 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p