YPL127C / HHO1

Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL127C / HHO1

Click on Significant Values for Screen Details ID:SGTC_161|Compound:4065-0411|FD-Score:-3.63|P-value:5.51E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.08|P-value:7.27E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.91|P-value:9.97E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.30|P-value:2.15E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.64|P-value:5.67E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.48|P-value:1.09E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.17|P-value:3.85E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.43|P-value:1.35E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-2.96|P-value:7.99E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.08|P-value:7.49E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:6.01|P-value:8.56E-11 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.93|P-value:9.45E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.60|P-value:5.15E-7 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.24|P-value:2.91E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.35|P-value:1.77E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-2.97|P-value:7.68E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.21|P-value:3.04E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.09|P-value:4.86E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.12|P-value:4.73E-4 ID:SGTC_2272|Compound:7805186|FD-Score:4.56|P-value:6.55E-7 ID:SGTC_2306|Compound:7482397|FD-Score:3.21|P-value:3.33E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-2.93|P-value:8.71E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-2.93|P-value:8.80E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.02|P-value:6.70E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-5.20|P-value:1.52E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.13|P-value:4.50E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.41|P-value:1.49E-4 ID:SGTC_2834|Compound:9001755|FD-Score:5.13|P-value:2.46E-8 ID:SGTC_2868|Compound:9035608|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.01|P-value:6.57E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.02|P-value:6.27E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-4.25|P-value:2.87E-6 ID:SGTC_2972|Compound:9093619|FD-Score:-3.55|P-value:7.80E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.20|P-value:3.39E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.61|P-value:6.33E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.06|P-value:5.86E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.02|P-value:6.30E-4 ID:SGTC_3253|Compound:9135987|FD-Score:2.96|P-value:8.43E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.63|P-value:5.51E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.08|P-value:7.27E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.91|P-value:9.97E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.30|P-value:2.15E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.64|P-value:5.67E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.48|P-value:1.09E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.17|P-value:3.85E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.43|P-value:1.35E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-2.96|P-value:7.99E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.08|P-value:7.49E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:6.01|P-value:8.56E-11 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.93|P-value:9.45E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.60|P-value:5.15E-7 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.24|P-value:2.91E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.35|P-value:1.77E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-2.97|P-value:7.68E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.21|P-value:3.04E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.09|P-value:4.86E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.12|P-value:4.73E-4 ID:SGTC_2272|Compound:7805186|FD-Score:4.56|P-value:6.55E-7 ID:SGTC_2306|Compound:7482397|FD-Score:3.21|P-value:3.33E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-2.93|P-value:8.71E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-2.93|P-value:8.80E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.02|P-value:6.70E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-5.20|P-value:1.52E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.13|P-value:4.50E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.41|P-value:1.49E-4 ID:SGTC_2834|Compound:9001755|FD-Score:5.13|P-value:2.46E-8 ID:SGTC_2868|Compound:9035608|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.01|P-value:6.57E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.02|P-value:6.27E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-4.25|P-value:2.87E-6 ID:SGTC_2972|Compound:9093619|FD-Score:-3.55|P-value:7.80E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.20|P-value:3.39E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.61|P-value:6.33E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.06|P-value:5.86E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.02|P-value:6.30E-4 ID:SGTC_3253|Compound:9135987|FD-Score:2.96|P-value:8.43E-4

Top fitness defect scores for YPL127C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1145 3546-0597 6.01 10.2 µM 8.56E-11 mitochondrial processes 4 9.33E-10
2 SGTC_2834 9001755 5.13 58.4 µM 2.46E-8 14 1.42E-7
3 SGTC_1221 2958-7315 4.60 257.0 µM 5.15E-7 13 2.11E-6
4 SGTC_2272 7805186 4.56 180.0 µM 6.55E-7 cell wall signaling 15 2.62E-6
5 SGTC_169 k015-0017 4.08 16.0 µM 7.27E-6 17 2.23E-5
6 SGTC_1036 k216-0215 4.08 33.5 µM 7.49E-6 mitochondrial response to ROS 44 2.28E-5
7 SGTC_525 k781-2675 3.64 26.7 µM 5.67E-5 redox potentiating 62 1.39E-4
8 SGTC_3089 9117425 3.61 49.5 µM 6.33E-5 39 1.53E-4
9 SGTC_617 3770-0098 3.48 35.0 µM 1.09E-4 exosome 24 2.48E-4
10 SGTC_2868 9035608 3.48 32.5 µM 1.10E-4 30 2.50E-4
11 SGTC_869 0564-0080 3.43 44.1 µM 1.35E-4 35 2.99E-4
12 SGTC_2832 7992762 3.41 52.0 µM 1.49E-4 49 3.28E-4
13 SGTC_1222 0366-0074 3.24 1.2 µM 2.91E-4 TSC3-RPN4 41 5.96E-4
14 SGTC_2306 7482397 3.21 179.5 µM 3.33E-4 RPP1 & pyrimidine depletion 44 6.72E-4
15 SGTC_3055 9094636 3.20 49.5 µM 3.39E-4 32 6.82E-4
16 SGTC_868 0527-0199 3.17 213.0 µM 3.85E-4 fatty acid desaturase (OLE1) 54 7.65E-4
17 SGTC_2587 piperic acid 3.13 92.2 µM 4.50E-4 50 8.79E-4
18 SGTC_2116 5511452 3.12 16.9 µM 4.73E-4 45 9.19E-4
19 SGTC_3101 9120531 3.06 49.5 µM 5.86E-4 74 0.00111
20 SGTC_2344 7990960 3.02 77.0 µM 6.70E-4 64 0.00125

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.47E-11 YJL205C NCE101 hom Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences
0.110 1.64E-10 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.095 3.87E-8 YOL136C PFK27 hom 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
0.088 3.03E-7 YNL333W SNZ2 hom Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
0.088 3.78E-7 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.083 1.62E-6 YHR017W YSC83 hom Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
0.081 2.89E-6 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.080 3.81E-6 YLR459W GAB1 het GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
0.080 3.87E-6 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.079 4.94E-6 YFL016C MDJ1 hom Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
0.079 5.29E-6 YBR161W CSH1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
0.076 9.14E-6 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.074 1.67E-5 YMR319C FET4 hom Low-affinity Fe(II) transporter of the plasma membrane
0.074 1.66E-5 YNL023C FAP1 hom Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
0.072 2.86E-5 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication