YPL128C / TBF1

Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL128C / TBF1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.53|P-value:4.79E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:5.26|P-value:2.68E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:3.27|P-value:1.51E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:8.06|P-value:1.67E-19 ID:SGTC_103|Compound:0844-0104|FD-Score:3.26|P-value:1.63E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:7.29|P-value:2.72E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:5.51|P-value:4.91E-10 ID:SGTC_163|Compound:1327-0036|FD-Score:4.49|P-value:3.24E-7 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.37|P-value:6.74E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:3.20|P-value:2.05E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.30|P-value:1.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.13|P-value:2.78E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:2.86|P-value:8.12E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:2.92|P-value:6.50E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.68|P-value:2.36E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.89|P-value:8.58E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.58|P-value:3.74E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:2.88|P-value:7.50E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-2.74|P-value:9.55E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.74|P-value:1.79E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.57|P-value:2.84E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.03|P-value:4.18E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-2.85|P-value:6.34E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.14|P-value:2.63E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.69|P-value:6.56E-8 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.20|P-value:2.02E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:-2.88|P-value:5.74E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.58|P-value:3.76E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.14|P-value:2.28E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.10|P-value:2.83E-6 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.42|P-value:7.80E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.96|P-value:6.03E-6 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.00|P-value:3.57E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-3.47|P-value:4.49E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.94|P-value:4.50E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-3.25|P-value:1.25E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.81|P-value:1.24E-5 ID:SGTC_1984|Compound:st072354|FD-Score:2.99|P-value:4.81E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.36|P-value:7.65E-5 ID:SGTC_1987|Compound:st072290|FD-Score:3.27|P-value:1.51E-4 ID:SGTC_1989|Compound:st071868|FD-Score:7.31|P-value:2.30E-16 ID:SGTC_1995|Compound:st072814|FD-Score:-2.91|P-value:5.00E-4 ID:SGTC_1996|Compound:st072960|FD-Score:5.04|P-value:1.17E-8 ID:SGTC_1999|Compound:st074831|FD-Score:-4.21|P-value:1.07E-6 ID:SGTC_2049|Compound:5262831|FD-Score:-3.04|P-value:3.02E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-4.76|P-value:4.22E-8 ID:SGTC_2107|Compound:5363541|FD-Score:3.32|P-value:1.25E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.46|P-value:6.76E-5 ID:SGTC_2283|Compound:7944793|FD-Score:5.85|P-value:4.40E-11 ID:SGTC_2285|Compound:7945142|FD-Score:-4.28|P-value:7.13E-7 ID:SGTC_2296|Compound:7971656|FD-Score:3.87|P-value:9.53E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.19|P-value:2.15E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-2.92|P-value:4.79E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.91|P-value:2.72E-8 ID:SGTC_2586|Compound:curcumin|FD-Score:2.95|P-value:5.76E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.17|P-value:2.34E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.24|P-value:1.28E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-2.74|P-value:9.78E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.22|P-value:1.39E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-2.95|P-value:4.25E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.08|P-value:3.17E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.10|P-value:2.90E-6 ID:SGTC_3009|Compound:9080819|FD-Score:4.03|P-value:4.16E-6 ID:SGTC_3211|Compound:9128781|FD-Score:5.02|P-value:1.32E-8 ID:SGTC_3340|Compound:9146634|FD-Score:3.54|P-value:4.60E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:3.53|P-value:4.79E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:5.26|P-value:2.68E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:3.27|P-value:1.51E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:8.06|P-value:1.67E-19 ID:SGTC_103|Compound:0844-0104|FD-Score:3.26|P-value:1.63E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:7.29|P-value:2.72E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:5.51|P-value:4.91E-10 ID:SGTC_163|Compound:1327-0036|FD-Score:4.49|P-value:3.24E-7 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.37|P-value:6.74E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:3.20|P-value:2.05E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.30|P-value:1.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.13|P-value:2.78E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:2.86|P-value:8.12E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:2.92|P-value:6.50E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.68|P-value:2.36E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.89|P-value:8.58E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.58|P-value:3.74E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:2.88|P-value:7.50E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-2.74|P-value:9.55E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.74|P-value:1.79E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.57|P-value:2.84E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.03|P-value:4.18E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-2.85|P-value:6.34E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.14|P-value:2.63E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.69|P-value:6.56E-8 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.20|P-value:2.02E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:-2.88|P-value:5.74E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.58|P-value:3.76E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.14|P-value:2.28E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.10|P-value:2.83E-6 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.42|P-value:7.80E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.96|P-value:6.03E-6 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.00|P-value:3.57E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-3.47|P-value:4.49E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.94|P-value:4.50E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-3.25|P-value:1.25E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.81|P-value:1.24E-5 ID:SGTC_1984|Compound:st072354|FD-Score:2.99|P-value:4.81E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.36|P-value:7.65E-5 ID:SGTC_1987|Compound:st072290|FD-Score:3.27|P-value:1.51E-4 ID:SGTC_1989|Compound:st071868|FD-Score:7.31|P-value:2.30E-16 ID:SGTC_1995|Compound:st072814|FD-Score:-2.91|P-value:5.00E-4 ID:SGTC_1996|Compound:st072960|FD-Score:5.04|P-value:1.17E-8 ID:SGTC_1999|Compound:st074831|FD-Score:-4.21|P-value:1.07E-6 ID:SGTC_2049|Compound:5262831|FD-Score:-3.04|P-value:3.02E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-4.76|P-value:4.22E-8 ID:SGTC_2107|Compound:5363541|FD-Score:3.32|P-value:1.25E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.46|P-value:6.76E-5 ID:SGTC_2283|Compound:7944793|FD-Score:5.85|P-value:4.40E-11 ID:SGTC_2285|Compound:7945142|FD-Score:-4.28|P-value:7.13E-7 ID:SGTC_2296|Compound:7971656|FD-Score:3.87|P-value:9.53E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.19|P-value:2.15E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-2.92|P-value:4.79E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.91|P-value:2.72E-8 ID:SGTC_2586|Compound:curcumin|FD-Score:2.95|P-value:5.76E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.17|P-value:2.34E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.24|P-value:1.28E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-2.74|P-value:9.78E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.22|P-value:1.39E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-2.95|P-value:4.25E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.08|P-value:3.17E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.10|P-value:2.90E-6 ID:SGTC_3009|Compound:9080819|FD-Score:4.03|P-value:4.16E-6 ID:SGTC_3211|Compound:9128781|FD-Score:5.02|P-value:1.32E-8 ID:SGTC_3340|Compound:9146634|FD-Score:3.54|P-value:4.60E-5

Top fitness defect scores for YPL128C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_81 0411-0046 8.06 10.0 µM 1.67E-19 14 3.82E-16 1.08
2 SGTC_1989 st071868 7.31 50.2 µM 2.30E-16 1 1.32E-13 1.59
3 SGTC_137 0438-0332 7.29 85.4 µM 2.72E-16 ubiquinone biosynthesis & proteasome 13 1.51E-13 0.05
4 SGTC_2283 7944793 5.85 200.0 µM 4.40E-11 3 2.51E-9 0.56
5 SGTC_158 k038-0087 5.51 26.4 µM 4.91E-10 ubiquinone biosynthesis & proteasome 17 1.78E-8 0.34
6 SGTC_36 0335-0881 5.26 14.2 µM 2.68E-9 ubiquinone biosynthesis & proteasome 20 7.07E-8 0.01
7 SGTC_1996 st072960 5.04 66.8 µM 1.17E-8 2 2.34E-7 0.56
8 SGTC_3211 9128781 5.02 49.5 µM 1.32E-8 7 2.58E-7 0.02
9 SGTC_2574 2',4'-dihydroxychalcone 4.91 14.6 µM 2.72E-8 6 4.65E-7 0.54
10 SGTC_163 1327-0036 4.49 7.5 µM 3.24E-7 42 3.49E-6 0.17
11 SGTC_256 clotrimazole 4.37 625.0 nM 6.74E-7 ergosterol depletion effects on membrane 15 6.35E-6 0.10
12 SGTC_1082 camptothecin 4.14 424.9 nM 2.28E-6 DNA damage response 17 1.72E-5 0.01
13 SGTC_1122 capsaicin 4.10 818.6 nM 2.83E-6 3 2.05E-5 0.06
14 SGTC_2814 7977482 4.10 43.0 µM 2.90E-6 11 2.09E-5 0.22
15 SGTC_2809 7964133 4.08 13.0 µM 3.17E-6 60S ribosome export 11 2.25E-5 0.03
16 SGTC_3009 9080819 4.03 71.4 µM 4.16E-6 10 2.81E-5 0.12
17 SGTC_1239 0337-0584 3.96 35.4 µM 6.03E-6 unfolded protein response 31 3.80E-5 0.14
18 SGTC_628 1636-0253 3.89 16.0 µM 8.58E-6 sphingolipid biosynthesis & PDR1 10 5.07E-5 0.10
19 SGTC_2296 7971656 3.87 126.5 µM 9.53E-6 9 5.53E-5 0.53
20 SGTC_1936 st074407 3.81 74.3 µM 1.24E-5 DNA damage response 11 6.87E-5 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.243 3.19E-46 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.209 2.62E-34 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.205 4.62E-33 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.200 1.08E-31 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.186 1.36E-27 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186 1.62E-27 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.186 1.87E-27 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.185 3.71E-27 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.180 5.79E-26 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.180 8.37E-26 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.179 1.71E-25 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.177 6.34E-25 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.172 8.99E-24 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.171 2.13E-23 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.170 4.45E-23 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress