YPL131W / RPL5

Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL131W / RPL5

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.88|P-value:4.36E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.92|P-value:1.23E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:4.76|P-value:2.21E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:4.47|P-value:6.25E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:5.33|P-value:2.38E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:5.47|P-value:1.37E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.83|P-value:5.01E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.96|P-value:3.41E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-4.06|P-value:2.48E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.87|P-value:4.48E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.66|P-value:8.51E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.85|P-value:4.72E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.70|P-value:7.49E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.50|P-value:5.65E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.80|P-value:5.61E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.21|P-value:1.51E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.58|P-value:4.33E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:6.37|P-value:2.33E-8 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.97|P-value:3.26E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.28|P-value:1.19E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.99|P-value:3.07E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.34|P-value:9.82E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.66|P-value:3.21E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.37|P-value:8.94E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.11|P-value:2.12E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.48|P-value:1.29E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.23|P-value:1.41E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.98|P-value:9.75E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.23|P-value:3.62E-6 ID:SGTC_1689|Compound:st020265|FD-Score:4.63|P-value:3.55E-5 ID:SGTC_1700|Compound:st030840|FD-Score:4.05|P-value:2.56E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.95|P-value:3.46E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.79|P-value:5.63E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.36|P-value:9.27E-5 ID:SGTC_1750|Compound:st081859|FD-Score:9.37|P-value:4.55E-16 ID:SGTC_1775|Compound:st081588|FD-Score:-4.47|P-value:6.20E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-6.79|P-value:2.79E-9 ID:SGTC_1800|Compound:st050079|FD-Score:-4.49|P-value:5.72E-5 ID:SGTC_1803|Compound:st050068|FD-Score:-3.76|P-value:6.24E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.31|P-value:1.07E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-4.47|P-value:6.31E-5 ID:SGTC_1846|Compound:st056244|FD-Score:5.28|P-value:2.94E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-4.04|P-value:2.60E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.69|P-value:2.83E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-3.62|P-value:9.48E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.78|P-value:3.53E-7 ID:SGTC_2066|Compound:5222451|FD-Score:-4.68|P-value:2.94E-5 ID:SGTC_2080|Compound:5212524|FD-Score:5.02|P-value:8.30E-6 ID:SGTC_2092|Compound:5303694|FD-Score:-3.92|P-value:3.82E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.72|P-value:7.05E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.77|P-value:5.97E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-5.51|P-value:1.11E-6 ID:SGTC_2192|Compound:5915882|FD-Score:5.18|P-value:4.39E-6 ID:SGTC_2205|Compound:7238770|FD-Score:-3.96|P-value:3.34E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.72|P-value:7.17E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.45|P-value:6.72E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.88|P-value:4.38E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.23|P-value:1.40E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.68|P-value:8.08E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.74|P-value:2.41E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.08|P-value:2.36E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.21|P-value:1.53E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.80|P-value:5.52E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.20|P-value:1.58E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.99|P-value:9.19E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.53|P-value:1.05E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-7.92|P-value:5.35E-12 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.87|P-value:4.50E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-4.36|P-value:9.16E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.67|P-value:8.20E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.77|P-value:6.12E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.90|P-value:1.32E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.60|P-value:3.91E-5 ID:SGTC_2780|Compound:5215298|FD-Score:-3.61|P-value:9.83E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.79|P-value:5.74E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.01|P-value:2.92E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.86|P-value:1.55E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-3.90|P-value:4.10E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.24|P-value:1.38E-4 ID:SGTC_3027|Compound:9089541|FD-Score:7.53|P-value:5.22E-11 ID:SGTC_3071|Compound:9117417|FD-Score:5.03|P-value:7.84E-6 ID:SGTC_3080|Compound:9117754|FD-Score:-6.84|P-value:2.21E-9 ID:SGTC_3081|Compound:9117243|FD-Score:7.05|P-value:7.47E-10 ID:SGTC_3088|Compound:9117578|FD-Score:-3.78|P-value:5.92E-4 ID:SGTC_3113|Compound:9123498|FD-Score:7.24|P-value:2.66E-10 ID:SGTC_3126|Compound:9127922|FD-Score:5.04|P-value:7.68E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-11.00|P-value:1.35E-21 ID:SGTC_3145|Compound:9085516|FD-Score:6.26|P-value:3.96E-8 ID:SGTC_3152|Compound:9099253|FD-Score:-6.04|P-value:1.09E-7 ID:SGTC_3204|Compound:9114183|FD-Score:-4.10|P-value:2.14E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.79|P-value:5.75E-4 ID:SGTC_3216|Compound:9129716|FD-Score:5.61|P-value:7.31E-7 ID:SGTC_3219|Compound:9131112|FD-Score:-4.26|P-value:1.27E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-4.90|P-value:1.31E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.70|P-value:2.75E-5 ID:SGTC_3268|Compound:9137683|FD-Score:4.84|P-value:1.65E-5 ID:SGTC_3277|Compound:9138724|FD-Score:-3.68|P-value:8.00E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.88|P-value:4.36E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.92|P-value:1.23E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:4.76|P-value:2.21E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:4.47|P-value:6.25E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:5.33|P-value:2.38E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:5.47|P-value:1.37E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.83|P-value:5.01E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.96|P-value:3.41E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-4.06|P-value:2.48E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.87|P-value:4.48E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.66|P-value:8.51E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.85|P-value:4.72E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.70|P-value:7.49E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.50|P-value:5.65E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.80|P-value:5.61E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.21|P-value:1.51E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.58|P-value:4.33E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:6.37|P-value:2.33E-8 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.97|P-value:3.26E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.28|P-value:1.19E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.99|P-value:3.07E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.34|P-value:9.82E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.66|P-value:3.21E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.37|P-value:8.94E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.11|P-value:2.12E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.48|P-value:1.29E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.23|P-value:1.41E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.98|P-value:9.75E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.23|P-value:3.62E-6 ID:SGTC_1689|Compound:st020265|FD-Score:4.63|P-value:3.55E-5 ID:SGTC_1700|Compound:st030840|FD-Score:4.05|P-value:2.56E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.95|P-value:3.46E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.79|P-value:5.63E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.36|P-value:9.27E-5 ID:SGTC_1750|Compound:st081859|FD-Score:9.37|P-value:4.55E-16 ID:SGTC_1775|Compound:st081588|FD-Score:-4.47|P-value:6.20E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-6.79|P-value:2.79E-9 ID:SGTC_1800|Compound:st050079|FD-Score:-4.49|P-value:5.72E-5 ID:SGTC_1803|Compound:st050068|FD-Score:-3.76|P-value:6.24E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.31|P-value:1.07E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-4.47|P-value:6.31E-5 ID:SGTC_1846|Compound:st056244|FD-Score:5.28|P-value:2.94E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-4.04|P-value:2.60E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.69|P-value:2.83E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-3.62|P-value:9.48E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.78|P-value:3.53E-7 ID:SGTC_2066|Compound:5222451|FD-Score:-4.68|P-value:2.94E-5 ID:SGTC_2080|Compound:5212524|FD-Score:5.02|P-value:8.30E-6 ID:SGTC_2092|Compound:5303694|FD-Score:-3.92|P-value:3.82E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.72|P-value:7.05E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.77|P-value:5.97E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-5.51|P-value:1.11E-6 ID:SGTC_2192|Compound:5915882|FD-Score:5.18|P-value:4.39E-6 ID:SGTC_2205|Compound:7238770|FD-Score:-3.96|P-value:3.34E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.72|P-value:7.17E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.45|P-value:6.72E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.88|P-value:4.38E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.23|P-value:1.40E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.68|P-value:8.08E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.74|P-value:2.41E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.08|P-value:2.36E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.21|P-value:1.53E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.80|P-value:5.52E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.20|P-value:1.58E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.99|P-value:9.19E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.53|P-value:1.05E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-7.92|P-value:5.35E-12 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.87|P-value:4.50E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-4.36|P-value:9.16E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.67|P-value:8.20E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.77|P-value:6.12E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.90|P-value:1.32E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.60|P-value:3.91E-5 ID:SGTC_2780|Compound:5215298|FD-Score:-3.61|P-value:9.83E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.79|P-value:5.74E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.01|P-value:2.92E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.86|P-value:1.55E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-3.90|P-value:4.10E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.24|P-value:1.38E-4 ID:SGTC_3027|Compound:9089541|FD-Score:7.53|P-value:5.22E-11 ID:SGTC_3071|Compound:9117417|FD-Score:5.03|P-value:7.84E-6 ID:SGTC_3080|Compound:9117754|FD-Score:-6.84|P-value:2.21E-9 ID:SGTC_3081|Compound:9117243|FD-Score:7.05|P-value:7.47E-10 ID:SGTC_3088|Compound:9117578|FD-Score:-3.78|P-value:5.92E-4 ID:SGTC_3113|Compound:9123498|FD-Score:7.24|P-value:2.66E-10 ID:SGTC_3126|Compound:9127922|FD-Score:5.04|P-value:7.68E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-11.00|P-value:1.35E-21 ID:SGTC_3145|Compound:9085516|FD-Score:6.26|P-value:3.96E-8 ID:SGTC_3152|Compound:9099253|FD-Score:-6.04|P-value:1.09E-7 ID:SGTC_3204|Compound:9114183|FD-Score:-4.10|P-value:2.14E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.79|P-value:5.75E-4 ID:SGTC_3216|Compound:9129716|FD-Score:5.61|P-value:7.31E-7 ID:SGTC_3219|Compound:9131112|FD-Score:-4.26|P-value:1.27E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-4.90|P-value:1.31E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.70|P-value:2.75E-5 ID:SGTC_3268|Compound:9137683|FD-Score:4.84|P-value:1.65E-5 ID:SGTC_3277|Compound:9138724|FD-Score:-3.68|P-value:8.00E-4

Top fitness defect scores for YPL131W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1750 st081859 9.37 2.4 µM 4.55E-16 endomembrane recycling 5 3.65E-21 0.26
2 SGTC_3027 9089541 7.53 49.5 µM 5.22E-11 fatty acid desaturase (OLE1) 1 2.53E-14 0.70
3 SGTC_3113 9123498 7.24 49.5 µM 2.66E-10 1 2.28E-13 2.26
4 SGTC_3081 9117243 7.05 49.5 µM 7.47E-10 fatty acid desaturase (OLE1) 6 9.20E-13 0.08
5 SGTC_832 4083-0019 6.37 164.0 µM 2.33E-8 translation 8 9.49E-11 0.33
6 SGTC_3145 9085516 6.26 49.5 µM 3.96E-8 fatty acid desaturase (OLE1) 5 1.94E-10 0.82
7 SGTC_2050 5263056 5.78 171.0 µM 3.53E-7 fatty acid desaturase (OLE1) 14 3.70E-9 0.84
8 SGTC_3216 9129716 5.61 49.5 µM 7.31E-7 RPP1 & pyrimidine depletion 3 9.86E-9 0.68
9 SGTC_1319 1306-0155 5.48 43.7 µM 1.29E-6 4 2.13E-8 0.28
10 SGTC_258 haloperidol 5.47 50.8 µM 1.37E-6 fatty acid desaturase (OLE1) 5 2.31E-8 0.04
11 SGTC_246 cycloheximide 5.33 667.0 µM 2.38E-6 4 4.81E-8 0.07
12 SGTC_1846 st056244 5.28 14.8 µM 2.94E-6 2 6.41E-8 1.03
13 SGTC_2192 5915882 5.18 198.5 µM 4.39E-6 RNA processing & uracil transport 9 1.10E-7 0.48
14 SGTC_3126 9127922 5.04 49.5 µM 7.68E-6 fatty acid desaturase (OLE1) 15 2.33E-7 0.01
15 SGTC_3071 9117417 5.03 49.5 µM 7.84E-6 fatty acid desaturase (OLE1) 6 2.39E-7 0.14
16 SGTC_2080 5212524 5.02 12.4 µM 8.30E-6 copper-dependent oxidative stress 3 2.58E-7 0.77
17 SGTC_152 4469-0003 4.92 551.2 µM 1.23E-5 6 4.38E-7 0.02
18 SGTC_2920 7982904 4.86 15.8 µM 1.55E-5 7 5.97E-7 0.36
19 SGTC_3268 9137683 4.84 49.5 µM 1.65E-5 3 6.51E-7 0.54
20 SGTC_176 1486-1328 4.76 72.8 µM 2.21E-5 5 9.61E-7 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.304 2.68E-72 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.274 1.66E-58 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.234 1.88E-42 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.221 3.10E-38 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.221 3.74E-38 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.207 1.37E-33 YGL030W RPL30 het Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
0.204 8.96E-33 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.196 3.11E-30 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.195 5.33E-30 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.181 6.71E-26 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.174 3.88E-24 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.172 9.27E-24 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.172 1.27E-23 YLR075W RPL10 het Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects
0.169 9.72E-23 YKL180W RPL17A het Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.168 1.16E-22 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors