YPL132W / COX11

Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL132W / COX11

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:4.76|P-value:3.15E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:7.83|P-value:5.64E-14 ID:SGTC_116|Compound:0155-0182|FD-Score:3.32|P-value:8.05E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:23.20|P-value:1.44E-107 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.27|P-value:2.96E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:28.80|P-value:6.18E-165 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.71|P-value:2.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.52|P-value:4.93E-13 ID:SGTC_335|Compound:4077-0256|FD-Score:3.44|P-value:5.48E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:18.30|P-value:4.72E-68 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.91|P-value:1.08E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:5.29|P-value:2.65E-7 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.69|P-value:2.43E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.31|P-value:8.75E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.57|P-value:3.51E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.58|P-value:3.44E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.50|P-value:4.68E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.46|P-value:5.22E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.48|P-value:4.73E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.78|P-value:1.72E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-3.76|P-value:1.88E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-3.38|P-value:6.83E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.05|P-value:6.20E-5 ID:SGTC_1635|Compound:st007035|FD-Score:22.30|P-value:1.89E-99 ID:SGTC_1770|Compound:st043884|FD-Score:3.71|P-value:2.17E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.45|P-value:1.19E-7 ID:SGTC_2271|Compound:7849410|FD-Score:-3.79|P-value:1.65E-4 ID:SGTC_2371|Compound:9071574|FD-Score:-3.42|P-value:6.01E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.39|P-value:6.54E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.79|P-value:2.77E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.50|P-value:1.01E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.43|P-value:5.58E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.57|P-value:3.62E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.99|P-value:7.63E-5 ID:SGTC_2781|Compound:5567276|FD-Score:-3.33|P-value:8.11E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.17|P-value:3.73E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.92|P-value:1.01E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.76|P-value:3.15E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:7.83|P-value:5.64E-14 ID:SGTC_116|Compound:0155-0182|FD-Score:3.32|P-value:8.05E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:23.20|P-value:1.44E-107 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.27|P-value:2.96E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:28.80|P-value:6.18E-165 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.71|P-value:2.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.52|P-value:4.93E-13 ID:SGTC_335|Compound:4077-0256|FD-Score:3.44|P-value:5.48E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:18.30|P-value:4.72E-68 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.91|P-value:1.08E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:5.29|P-value:2.65E-7 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.69|P-value:2.43E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.31|P-value:8.75E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.57|P-value:3.51E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.58|P-value:3.44E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.50|P-value:4.68E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.46|P-value:5.22E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.48|P-value:4.73E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.78|P-value:1.72E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-3.76|P-value:1.88E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-3.38|P-value:6.83E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.05|P-value:6.20E-5 ID:SGTC_1635|Compound:st007035|FD-Score:22.30|P-value:1.89E-99 ID:SGTC_1770|Compound:st043884|FD-Score:3.71|P-value:2.17E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.45|P-value:1.19E-7 ID:SGTC_2271|Compound:7849410|FD-Score:-3.79|P-value:1.65E-4 ID:SGTC_2371|Compound:9071574|FD-Score:-3.42|P-value:6.01E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.39|P-value:6.54E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.79|P-value:2.77E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.50|P-value:1.01E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.43|P-value:5.58E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.57|P-value:3.62E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.99|P-value:7.63E-5 ID:SGTC_2781|Compound:5567276|FD-Score:-3.33|P-value:8.11E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.17|P-value:3.73E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.92|P-value:1.01E-4

Top fitness defect scores for YPL132W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 28.80 5.3 µM 6.18E-165 20 2.66E-183
2 SGTC_134 0269-0018 23.20 6.9 µM 1.44E-107 2 1.87E-119
3 SGTC_1635 st007035 22.30 42.4 µM 1.89E-99 17 2.03E-110
4 SGTC_386 1509-0011 18.30 3.1 µM 4.72E-68 11 1.76E-75
5 SGTC_66 0109-0187 7.83 42.4 µM 5.64E-14 4 2.45E-15
6 SGTC_310 1273-0058 7.52 1.1 µM 4.93E-13 mitochondrial stress 102 2.72E-14
7 SGTC_1772 st048439 5.45 82.2 µM 1.19E-7 14 2.56E-8
8 SGTC_428 3448-4153 5.29 16.5 µM 2.65E-7 TSC3-RPN4 13 6.22E-8
9 SGTC_2415 st077333 4.79 57.7 µM 2.77E-6 22 8.38E-7
10 SGTC_59 0330-0160 4.76 1.3 µM 3.15E-6 73 9.67E-7
11 SGTC_3304 9125678 4.17 46.1 µM 3.73E-5 39 1.49E-5
12 SGTC_2627 acetyl isogambogic acid 3.99 100.0 µM 7.63E-5 TSC3-RPN4 40 3.30E-5
13 SGTC_3305 9127027 3.92 53.8 µM 1.01E-4 16 4.49E-5
14 SGTC_240 5hr heat shock (37°C) + Streptovitacin 3.71 300.0 µM 2.16E-4 heat shock/prefoldin 48 1.04E-4
15 SGTC_1770 st043884 3.71 66.3 µM 2.17E-4 18 1.05E-4
16 SGTC_976 1348-1067 3.58 47.6 µM 3.44E-4 60S ribosome export 44 1.74E-4
17 SGTC_972 1319-0219 3.57 195.0 µM 3.51E-4 48 1.78E-4
18 SGTC_1183 1254-0324 3.48 198.0 µM 4.73E-4 38 2.47E-4
19 SGTC_335 4077-0256 3.44 27.6 µM 5.48E-4 25 2.91E-4
20 SGTC_2533 agelasine 3.43 13.7 µM 5.58E-4 ERG2 71 2.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.756 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.750 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.748 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.733 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.730 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.723 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.719 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.710 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.709 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.709 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.702 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.700 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.699 0 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.697 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.683 0 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress