YPL134C / ODC1

Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL134C / ODC1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.85|P-value:3.05E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:2.99|P-value:9.29E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.63|P-value:7.86E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:3.16|P-value:5.00E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:5.19|P-value:3.11E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.95|P-value:1.93E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:3.42|P-value:1.80E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:6.39|P-value:1.42E-11 ID:SGTC_351|Compound:caspofungin|FD-Score:4.59|P-value:8.42E-7 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.01|P-value:1.48E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:4.30|P-value:3.66E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:3.60|P-value:8.72E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.53|P-value:1.16E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.57|P-value:9.92E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.45|P-value:1.65E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:3.01|P-value:8.43E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.40|P-value:2.00E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.62|P-value:8.10E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.01|P-value:8.63E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.30|P-value:2.93E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.16|P-value:7.14E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.02|P-value:8.22E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.26|P-value:3.34E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:2.97|P-value:9.70E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.01|P-value:8.64E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.20|P-value:4.21E-4 ID:SGTC_1720|Compound:st037298|FD-Score:8.91|P-value:8.28E-21 ID:SGTC_1784|Compound:st039334|FD-Score:3.51|P-value:1.27E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.31|P-value:2.81E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.44|P-value:1.66E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.42|P-value:1.83E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.11|P-value:9.19E-6 ID:SGTC_1986|Compound:st071812|FD-Score:2.98|P-value:9.41E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.40|P-value:1.99E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.77|P-value:4.18E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.35|P-value:2.38E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.43|P-value:1.93E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.01|P-value:8.76E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.53|P-value:1.19E-4 ID:SGTC_2402|Compound:5553605|FD-Score:5.35|P-value:1.28E-8 ID:SGTC_2462|Compound:5162487|FD-Score:3.16|P-value:5.01E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.70|P-value:5.87E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.98|P-value:1.68E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.23|P-value:3.74E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.43|P-value:1.79E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.43|P-value:1.75E-4 ID:SGTC_2806|Compound:7952793|FD-Score:6.29|P-value:2.84E-11 ID:SGTC_2836|Compound:9010338|FD-Score:5.49|P-value:5.18E-9 ID:SGTC_2839|Compound:9003951|FD-Score:3.04|P-value:7.58E-4 ID:SGTC_2892|Compound:9047358|FD-Score:4.00|P-value:1.54E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-4.62|P-value:7.66E-7 ID:SGTC_2923|Compound:7992654|FD-Score:5.70|P-value:1.43E-9 ID:SGTC_2931|Compound:9014674|FD-Score:3.55|P-value:1.07E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.79|P-value:2.96E-7 ID:SGTC_2982|Compound:9019404|FD-Score:-3.20|P-value:4.41E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.03|P-value:7.96E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.55|P-value:1.09E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.24|P-value:3.66E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.40|P-value:2.03E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.56|P-value:1.08E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-4.07|P-value:1.15E-5 ID:SGTC_3260|Compound:9137109|FD-Score:-4.60|P-value:8.50E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.85|P-value:3.05E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:2.99|P-value:9.29E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.63|P-value:7.86E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:3.16|P-value:5.00E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:5.19|P-value:3.11E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.95|P-value:1.93E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:3.42|P-value:1.80E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:6.39|P-value:1.42E-11 ID:SGTC_351|Compound:caspofungin|FD-Score:4.59|P-value:8.42E-7 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.01|P-value:1.48E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:4.30|P-value:3.66E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:3.60|P-value:8.72E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.53|P-value:1.16E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.57|P-value:9.92E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.45|P-value:1.65E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:3.01|P-value:8.43E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.40|P-value:2.00E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.62|P-value:8.10E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.01|P-value:8.63E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.30|P-value:2.93E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.16|P-value:7.14E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.02|P-value:8.22E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.26|P-value:3.34E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:2.97|P-value:9.70E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.01|P-value:8.64E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.20|P-value:4.21E-4 ID:SGTC_1720|Compound:st037298|FD-Score:8.91|P-value:8.28E-21 ID:SGTC_1784|Compound:st039334|FD-Score:3.51|P-value:1.27E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.31|P-value:2.81E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.44|P-value:1.66E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.42|P-value:1.83E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.11|P-value:9.19E-6 ID:SGTC_1986|Compound:st071812|FD-Score:2.98|P-value:9.41E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.40|P-value:1.99E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.77|P-value:4.18E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.35|P-value:2.38E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.43|P-value:1.93E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.01|P-value:8.76E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.53|P-value:1.19E-4 ID:SGTC_2402|Compound:5553605|FD-Score:5.35|P-value:1.28E-8 ID:SGTC_2462|Compound:5162487|FD-Score:3.16|P-value:5.01E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.70|P-value:5.87E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.98|P-value:1.68E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.23|P-value:3.74E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.43|P-value:1.79E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.43|P-value:1.75E-4 ID:SGTC_2806|Compound:7952793|FD-Score:6.29|P-value:2.84E-11 ID:SGTC_2836|Compound:9010338|FD-Score:5.49|P-value:5.18E-9 ID:SGTC_2839|Compound:9003951|FD-Score:3.04|P-value:7.58E-4 ID:SGTC_2892|Compound:9047358|FD-Score:4.00|P-value:1.54E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-4.62|P-value:7.66E-7 ID:SGTC_2923|Compound:7992654|FD-Score:5.70|P-value:1.43E-9 ID:SGTC_2931|Compound:9014674|FD-Score:3.55|P-value:1.07E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.79|P-value:2.96E-7 ID:SGTC_2982|Compound:9019404|FD-Score:-3.20|P-value:4.41E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.03|P-value:7.96E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.55|P-value:1.09E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.24|P-value:3.66E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.40|P-value:2.03E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.56|P-value:1.08E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-4.07|P-value:1.15E-5 ID:SGTC_3260|Compound:9137109|FD-Score:-4.60|P-value:8.50E-7

Top fitness defect scores for YPL134C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1720 st037298 8.91 9.5 µM 8.28E-21 2 2.55E-19
2 SGTC_342 k048-0088 6.39 23.3 µM 1.42E-11 RSC & ERG11 2 8.47E-11
3 SGTC_2806 7952793 6.29 58.4 µM 2.84E-11 5 1.60E-10
4 SGTC_2923 7992654 5.70 58.1 µM 1.43E-9 Golgi 7 5.97E-9
5 SGTC_2836 9010338 5.49 19.5 µM 5.18E-9 RPP1 & pyrimidine depletion 6 1.96E-8
6 SGTC_2402 5553605 5.35 200.0 µM 1.28E-8 8 4.52E-8
7 SGTC_172 1112-0046 5.19 2.6 µM 3.11E-8 NEO1 19 1.03E-7
8 SGTC_2978 9011784 4.79 43.0 µM 2.96E-7 14 8.24E-7
9 SGTC_351 caspofungin 4.59 25.0 nM 8.42E-7 cell wall 68 2.17E-6
10 SGTC_2302 7771753 4.43 200.0 µM 1.93E-6 31 4.66E-6
11 SGTC_502 l-744,832 4.30 89.3 µM 3.66E-6 calcium & mitochondrial duress 31 8.43E-6
12 SGTC_1047 2043-3044 4.16 82.0 µM 7.14E-6 27 1.56E-5
13 SGTC_1978 st071761 4.11 42.0 µM 9.19E-6 TSC3-RPN4 12 1.98E-5
14 SGTC_464 bw-b 70c 4.01 158.0 µM 1.48E-5 24 3.07E-5
15 SGTC_2892 9047358 4.00 58.4 µM 1.54E-5 7 3.19E-5
16 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.98 63.6 µM 1.68E-5 40 3.45E-5
17 SGTC_2184 6075246 3.77 200.0 µM 4.18E-5 31 8.02E-5
18 SGTC_2470 5664817 3.70 21.7 µM 5.87E-5 15 1.10E-4
19 SGTC_104 0074-0074 3.63 591.0 µM 7.86E-5 10 1.44E-4
20 SGTC_963 1269-2853 3.62 151.0 µM 8.10E-5 37 1.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.30E-11 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.113 6.38E-11 YOL042W NGL1 hom Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.092 9.47E-8 YPL221W FLC1 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.092 9.66E-8 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.092 1.06E-7 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.090 1.61E-7 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.085 7.43E-7 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.079 4.97E-6 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.078 6.89E-6 YIL051C MMF1 het Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
0.077 7.82E-6 YJL192C SOP4 hom ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
0.076 1.07E-5 YGR040W KSS1 hom Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
0.075 1.31E-5 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.075 1.36E-5 YPL032C SVL3 hom Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.074 1.79E-5 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.074 1.92E-5 YOR076C SKI7 hom Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype