YPL136W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL136W / YPL136W

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:3.74|P-value:2.62E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.41|P-value:2.20E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:-5.13|P-value:1.49E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:3.62|P-value:3.98E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.73|P-value:2.74E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.38|P-value:8.56E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.47|P-value:1.77E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:-3.58|P-value:5.75E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.14|P-value:6.42E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.46|P-value:6.72E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.42|P-value:7.54E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.89|P-value:1.55E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.59|P-value:4.30E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.46|P-value:1.83E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.49|P-value:1.60E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.49|P-value:7.74E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.37|P-value:6.25E-15 ID:SGTC_1910|Compound:st062352|FD-Score:-3.68|P-value:4.18E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.93|P-value:1.35E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-4.01|P-value:1.38E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.40|P-value:8.03E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.66|P-value:3.43E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.80|P-value:2.16E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.50|P-value:7.50E-4 ID:SGTC_2466|Compound:5983409|FD-Score:5.24|P-value:6.40E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.77|P-value:2.41E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.98|P-value:1.12E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.34|P-value:2.93E-5 ID:SGTC_2791|Compound:5663188|FD-Score:4.92|P-value:2.65E-6 ID:SGTC_2866|Compound:9034245|FD-Score:3.35|P-value:9.43E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.91|P-value:1.93E-4 ID:SGTC_3207|Compound:9114163|FD-Score:6.05|P-value:1.18E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:3.74|P-value:2.62E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.41|P-value:2.20E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:-5.13|P-value:1.49E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:3.62|P-value:3.98E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.73|P-value:2.74E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.38|P-value:8.56E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.47|P-value:1.77E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:-3.58|P-value:5.75E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.14|P-value:6.42E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.46|P-value:6.72E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.42|P-value:7.54E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.89|P-value:1.55E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.59|P-value:4.30E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.46|P-value:1.83E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.49|P-value:1.60E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.49|P-value:7.74E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.37|P-value:6.25E-15 ID:SGTC_1910|Compound:st062352|FD-Score:-3.68|P-value:4.18E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.93|P-value:1.35E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-4.01|P-value:1.38E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.40|P-value:8.03E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.66|P-value:3.43E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.80|P-value:2.16E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.50|P-value:7.50E-4 ID:SGTC_2466|Compound:5983409|FD-Score:5.24|P-value:6.40E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.77|P-value:2.41E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.98|P-value:1.12E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.34|P-value:2.93E-5 ID:SGTC_2791|Compound:5663188|FD-Score:4.92|P-value:2.65E-6 ID:SGTC_2866|Compound:9034245|FD-Score:3.35|P-value:9.43E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.91|P-value:1.93E-4 ID:SGTC_3207|Compound:9114163|FD-Score:6.05|P-value:1.18E-8

Top fitness defect scores for YPL136W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 8.37 55.4 µM 6.25E-15 63 2.96E-17
2 SGTC_3207 9114163 6.05 49.5 µM 1.18E-8 5 7.35E-10
3 SGTC_2466 5983409 5.24 37.1 µM 6.40E-7 7 8.03E-8
4 SGTC_2791 5663188 4.92 71.4 µM 2.65E-6 RPP1 & pyrimidine depletion 5 4.25E-7
5 SGTC_1616 st002734 4.49 56.1 µM 1.60E-5 18 3.49E-6
6 SGTC_1147 3809-1045 4.47 12.3 µM 1.77E-5 15 3.93E-6
7 SGTC_1539 benzyladenosine 4.46 56.0 µM 1.83E-5 8 4.08E-6
8 SGTC_158 k038-0087 4.41 26.4 µM 2.20E-5 ubiquinone biosynthesis & proteasome 111 5.08E-6
9 SGTC_2770 toltrazuril 4.34 17.5 µM 2.93E-5 14 7.10E-6
10 SGTC_1160 4092-0570 4.14 10.5 µM 6.42E-5 plasma membrane duress 34 1.77E-5
11 SGTC_2547 epiafzelechin trimethyl ether 3.98 100.0 µM 1.12E-4 3 3.40E-5
12 SGTC_1934 st074720 3.93 32.6 µM 1.35E-4 58 4.23E-5
13 SGTC_1233 0325-0408 3.89 14.2 µM 1.55E-4 21 4.98E-5
14 SGTC_2329 6138490 3.80 200.0 µM 2.16E-4 38 7.32E-5
15 SGTC_2541 muurolladie-3-one 3.77 83.1 µM 2.41E-4 excess fatty acid 37 8.29E-5
16 SGTC_86 0417-1630 3.74 471.9 µM 2.62E-4 ubiquinone biosynthesis & proteasome 165 9.16E-5
17 SGTC_425 3825-7017 3.73 13.1 µM 2.74E-4 28 9.64E-5
18 SGTC_2318 6029776 3.66 164.0 µM 3.43E-4 39 1.25E-4
19 SGTC_371 0195-0006 3.62 7.4 µM 3.98E-4 29 1.49E-4
20 SGTC_1404 3909-7820 3.59 48.3 µM 4.30E-4 60S ribosome export 13 1.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.40E-15 YPR070W MED1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.135 3.41E-15 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.133 8.75E-15 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.131 2.20E-14 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.127 1.76E-13 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.126 2.17E-13 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.126 2.98E-13 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.125 3.27E-13 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.125 3.28E-13 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.123 9.52E-13 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.118 7.53E-12 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.116 1.69E-11 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.115 2.48E-11 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 3.13E-11 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.114 4.15E-11 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation