YPL137C / GIP3

Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL137C / GIP3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.12|P-value:7.68E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.11|P-value:8.94E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.93|P-value:3.42E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:4.19|P-value:1.28E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.12|P-value:8.63E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.38|P-value:3.42E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.55|P-value:1.84E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.22|P-value:6.10E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.20|P-value:8.30E-8 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.22|P-value:1.12E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.54|P-value:1.64E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.25|P-value:5.56E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.36|P-value:3.73E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-4.75|P-value:7.35E-7 ID:SGTC_460|Compound:trequinsin|FD-Score:-3.35|P-value:3.36E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.93|P-value:1.16E-9 ID:SGTC_786|Compound:4544-0069|FD-Score:7.50|P-value:2.11E-14 ID:SGTC_790|Compound:1575-0012|FD-Score:4.08|P-value:2.06E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.34|P-value:4.03E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:5.04|P-value:2.03E-7 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.42|P-value:2.98E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.74|P-value:7.59E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.52|P-value:1.78E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.37|P-value:3.54E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.10|P-value:9.24E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-4.12|P-value:1.48E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.49|P-value:2.03E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.37|P-value:3.56E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.85|P-value:5.21E-7 ID:SGTC_1952|Compound:st077036|FD-Score:4.80|P-value:7.00E-7 ID:SGTC_2014|Compound:4013930|FD-Score:-3.31|P-value:3.95E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.12|P-value:7.74E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.88|P-value:4.75E-5 ID:SGTC_2411|Compound:st077133|FD-Score:4.09|P-value:1.92E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.41|P-value:4.55E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-4.58|P-value:1.76E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.79|P-value:7.02E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.23|P-value:1.05E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_2784|Compound:7567673|FD-Score:6.13|P-value:3.33E-10 ID:SGTC_2785|Compound:7756463|FD-Score:6.09|P-value:4.38E-10 ID:SGTC_2788|Compound:5282734|FD-Score:5.51|P-value:1.44E-8 ID:SGTC_2790|Compound:5423970|FD-Score:-4.03|P-value:2.17E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.57|P-value:1.68E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.06|P-value:9.58E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.94|P-value:3.68E-5 ID:SGTC_3333|Compound:9141820|FD-Score:-3.72|P-value:8.02E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.12|P-value:7.68E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.11|P-value:8.94E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.93|P-value:3.42E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:4.19|P-value:1.28E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.12|P-value:8.63E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.38|P-value:3.42E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.55|P-value:1.84E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.22|P-value:6.10E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.20|P-value:8.30E-8 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.22|P-value:1.12E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.54|P-value:1.64E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.25|P-value:5.56E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.36|P-value:3.73E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-4.75|P-value:7.35E-7 ID:SGTC_460|Compound:trequinsin|FD-Score:-3.35|P-value:3.36E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.93|P-value:1.16E-9 ID:SGTC_786|Compound:4544-0069|FD-Score:7.50|P-value:2.11E-14 ID:SGTC_790|Compound:1575-0012|FD-Score:4.08|P-value:2.06E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.34|P-value:4.03E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:5.04|P-value:2.03E-7 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.42|P-value:2.98E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.74|P-value:7.59E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.52|P-value:1.78E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.37|P-value:3.54E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.10|P-value:9.24E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-4.12|P-value:1.48E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.49|P-value:2.03E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.37|P-value:3.56E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.85|P-value:5.21E-7 ID:SGTC_1952|Compound:st077036|FD-Score:4.80|P-value:7.00E-7 ID:SGTC_2014|Compound:4013930|FD-Score:-3.31|P-value:3.95E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.12|P-value:7.74E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.88|P-value:4.75E-5 ID:SGTC_2411|Compound:st077133|FD-Score:4.09|P-value:1.92E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.41|P-value:4.55E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-4.58|P-value:1.76E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.79|P-value:7.02E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.23|P-value:1.05E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_2784|Compound:7567673|FD-Score:6.13|P-value:3.33E-10 ID:SGTC_2785|Compound:7756463|FD-Score:6.09|P-value:4.38E-10 ID:SGTC_2788|Compound:5282734|FD-Score:5.51|P-value:1.44E-8 ID:SGTC_2790|Compound:5423970|FD-Score:-4.03|P-value:2.17E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.57|P-value:1.68E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.06|P-value:9.58E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.94|P-value:3.68E-5 ID:SGTC_3333|Compound:9141820|FD-Score:-3.72|P-value:8.02E-5

Top fitness defect scores for YPL137C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_786 4544-0069 7.50 423.0 µM 2.11E-14 3 3.17E-14
2 SGTC_2784 7567673 6.13 72.7 µM 3.33E-10 iron homeostasis 5 4.30E-10
3 SGTC_2785 7756463 6.09 72.7 µM 4.38E-10 4 5.63E-10
4 SGTC_690 glyoxal 5.93 20.3 µM 1.16E-9 44 1.47E-9
5 SGTC_2788 5282734 5.51 71.4 µM 1.44E-8 15 1.76E-8
6 SGTC_266 formosanin C 5.20 406.0 nM 8.30E-8 sphingolipid biosynthesis & PDR1 42 9.86E-8
7 SGTC_978 1416-0512 5.04 87.4 µM 2.03E-7 redox potentiating 12 2.38E-7
8 SGTC_1941 st076221 4.85 61.8 µM 5.21E-7 sphingolipid biosynthesis & PDR1 52 6.03E-7
9 SGTC_1952 st077036 4.80 64.1 µM 7.00E-7 15 8.06E-7
10 SGTC_2499 avocadenofuran 4.41 51.5 µM 4.55E-6 23 5.10E-6
11 SGTC_2574 2',4'-dihydroxychalcone 4.23 14.6 µM 1.05E-5 16 1.16E-5
12 SGTC_272 doxorubicin 4.22 8.1 µM 1.12E-5 anthracycline transcription coupled DNA repair 16 1.24E-5
13 SGTC_121 0557-0495 4.19 61.3 µM 1.28E-5 calcium & mitochondrial duress 48 1.41E-5
14 SGTC_2411 st077133 4.09 39.9 µM 1.92E-5 RNA pol III & RNase P/MRP 29 2.11E-5
15 SGTC_790 1575-0012 4.08 79.1 µM 2.06E-5 TSC3-RPN4 26 2.26E-5
16 SGTC_3318 9139014 3.94 38.6 µM 3.68E-5 15 4.01E-5
17 SGTC_2375 9072683 3.88 200.0 µM 4.75E-5 mitochondrial processes 21 5.15E-5
18 SGTC_2557 derrustone 3.79 83.8 µM 7.02E-5 43 7.57E-5
19 SGTC_2773 thioridazine 3.66 9.1 µM 1.18E-4 18 1.26E-4
20 SGTC_3208 9114115 3.57 49.5 µM 1.68E-4 56 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.07E-15 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.121 1.77E-12 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.121 1.81E-12 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
0.118 7.36E-12 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.112 8.06E-11 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.106 8.46E-10 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 9.75E-10 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.105 1.01E-9 YJL078C PRY3 hom Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.104 1.29E-9 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.102 3.01E-9 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.101 4.24E-9 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.101 5.07E-9 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.100 6.98E-9 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.100 6.64E-9 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.100 7.13E-9 YJL128C PBS2 hom MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition