YPL138C / SPP1

Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL138C / SPP1

Click on Significant Values for Screen Details ID:SGTC_121|Compound:0557-0495|FD-Score:4.93|P-value:6.92E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:6.69|P-value:2.84E-11 ID:SGTC_157|Compound:1348-1695|FD-Score:3.35|P-value:5.15E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.45|P-value:1.36E-10 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.22|P-value:8.15E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.58|P-value:2.26E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.43|P-value:3.90E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.52|P-value:2.79E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:5.13|P-value:2.53E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:3.30|P-value:6.13E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.59|P-value:2.17E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.83|P-value:8.88E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:3.51|P-value:2.94E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.34|P-value:5.38E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.31|P-value:6.00E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.58|P-value:2.27E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.76|P-value:1.58E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.91|P-value:6.35E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.50|P-value:5.19E-6 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.85|P-value:8.10E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.67|P-value:1.62E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.61|P-value:1.97E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.55|P-value:2.64E-8 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.45|P-value:3.57E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.43|P-value:3.87E-4 ID:SGTC_1980|Compound:st071811|FD-Score:5.35|P-value:7.91E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.82|P-value:9.27E-5 ID:SGTC_1994|Compound:st072947|FD-Score:-3.24|P-value:7.52E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.42|P-value:4.02E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.16|P-value:9.81E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.48|P-value:3.26E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-4.03|P-value:4.03E-5 ID:SGTC_2284|Compound:7945075|FD-Score:-4.75|P-value:1.63E-6 ID:SGTC_2287|Compound:7945887|FD-Score:-6.17|P-value:7.66E-10 ID:SGTC_2288|Compound:7946289|FD-Score:3.77|P-value:1.11E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.95|P-value:5.53E-5 ID:SGTC_2298|Compound:7976326|FD-Score:4.17|P-value:2.22E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.17|P-value:9.44E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.52|P-value:2.89E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.18|P-value:1.90E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.10|P-value:3.00E-5 ID:SGTC_2423|Compound:st077119|FD-Score:5.16|P-value:2.15E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.14|P-value:2.57E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.86|P-value:7.85E-5 ID:SGTC_2701|Compound:st077767|FD-Score:4.15|P-value:2.39E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.21|P-value:8.31E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.77|P-value:1.12E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.73|P-value:1.29E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.78|P-value:1.40E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-3.32|P-value:5.78E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.93|P-value:6.92E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:6.69|P-value:2.84E-11 ID:SGTC_157|Compound:1348-1695|FD-Score:3.35|P-value:5.15E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.45|P-value:1.36E-10 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.22|P-value:8.15E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.58|P-value:2.26E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.43|P-value:3.90E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.52|P-value:2.79E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:5.13|P-value:2.53E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:3.30|P-value:6.13E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.59|P-value:2.17E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.83|P-value:8.88E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:3.51|P-value:2.94E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.34|P-value:5.38E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.31|P-value:6.00E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.58|P-value:2.27E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.76|P-value:1.58E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.91|P-value:6.35E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.50|P-value:5.19E-6 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.85|P-value:8.10E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.67|P-value:1.62E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.61|P-value:1.97E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.55|P-value:2.64E-8 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.45|P-value:3.57E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.43|P-value:3.87E-4 ID:SGTC_1980|Compound:st071811|FD-Score:5.35|P-value:7.91E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.82|P-value:9.27E-5 ID:SGTC_1994|Compound:st072947|FD-Score:-3.24|P-value:7.52E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.42|P-value:4.02E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.16|P-value:9.81E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.48|P-value:3.26E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-4.03|P-value:4.03E-5 ID:SGTC_2284|Compound:7945075|FD-Score:-4.75|P-value:1.63E-6 ID:SGTC_2287|Compound:7945887|FD-Score:-6.17|P-value:7.66E-10 ID:SGTC_2288|Compound:7946289|FD-Score:3.77|P-value:1.11E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.95|P-value:5.53E-5 ID:SGTC_2298|Compound:7976326|FD-Score:4.17|P-value:2.22E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.17|P-value:9.44E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.52|P-value:2.89E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.18|P-value:1.90E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.10|P-value:3.00E-5 ID:SGTC_2423|Compound:st077119|FD-Score:5.16|P-value:2.15E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.14|P-value:2.57E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.86|P-value:7.85E-5 ID:SGTC_2701|Compound:st077767|FD-Score:4.15|P-value:2.39E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.21|P-value:8.31E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.77|P-value:1.12E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.73|P-value:1.29E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.78|P-value:1.40E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-3.32|P-value:5.78E-4

Top fitness defect scores for YPL138C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 6.69 62.7 µM 2.84E-11 ubiquinone biosynthesis & proteasome 53 1.13E-11
2 SGTC_158 k038-0087 6.45 26.4 µM 1.36E-10 ubiquinone biosynthesis & proteasome 61 5.78E-11
3 SGTC_1240 0356-0016 5.61 42.1 µM 1.97E-8 mitochondrial response to ROS 9 1.03E-8
4 SGTC_513 4245-1575 5.59 41.7 µM 2.17E-8 unfolded protein response 60 1.14E-8
5 SGTC_1246 0422-0085 5.55 105.0 µM 2.64E-8 5 1.39E-8
6 SGTC_1980 st071811 5.35 45.7 µM 7.91E-8 RPP1 & pyrimidine depletion 3 4.36E-8
7 SGTC_2405 ticlatone 5.18 3.5 µM 1.90E-7 37 1.09E-7
8 SGTC_2423 st077119 5.16 87.2 µM 2.15E-7 5 1.23E-7
9 SGTC_346 4513-0042 5.13 7.2 µM 2.53E-7 azole & statin 17 1.46E-7
10 SGTC_121 0557-0495 4.93 61.3 µM 6.92E-7 calcium & mitochondrial duress 29 4.17E-7
11 SGTC_3204 9114183 4.78 49.5 µM 1.40E-6 13 8.70E-7
12 SGTC_934 2950-0684 4.76 338.0 µM 1.58E-6 9 9.85E-7
13 SGTC_997 3996-0078 4.50 137.0 µM 5.19E-6 10 3.39E-6
14 SGTC_2298 7976326 4.17 193.8 µM 2.22E-5 5 1.54E-5
15 SGTC_2701 st077767 4.15 14.7 µM 2.39E-5 40 1.66E-5
16 SGTC_137 0438-0332 4.10 85.4 µM 2.93E-5 ubiquinone biosynthesis & proteasome 117 2.06E-5
17 SGTC_2407 paclitaxel 4.10 400.0 µM 3.00E-5 32 2.10E-5
18 SGTC_2292 7671323 3.95 168.1 µM 5.53E-5 RNA processing & uracil transport 31 3.98E-5
19 SGTC_2651 1327-0036 3.86 5.0 µM 7.85E-5 165 5.73E-5
20 SGTC_1006 4099-6547 3.85 255.0 µM 8.10E-5 24 5.91E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 2.71E-33 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.202 3.04E-32 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.192 3.78E-29 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.188 4.47E-28 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.168 1.21E-22 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.161 5.66E-21 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.160 1.01E-20 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.150 2.59E-18 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.147 1.47E-17 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.146 1.67E-17 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.145 3.86E-17 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.143 1.03E-16 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.141 1.98E-16 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.139 5.20E-16 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.138 8.66E-16 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases