YPL139C / UME1

Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL139C / UME1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.36|P-value:4.02E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.28|P-value:5.40E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.32|P-value:4.66E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.96|P-value:3.92E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.28|P-value:5.42E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.14|P-value:8.91E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.44|P-value:3.03E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.64|P-value:1.85E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:5.67|P-value:7.81E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.89|P-value:1.97E-9 ID:SGTC_165|Compound:k038-0023|FD-Score:3.50|P-value:2.42E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.87|P-value:5.70E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.12|P-value:1.98E-5 ID:SGTC_263|Compound:alizarin|FD-Score:6.52|P-value:3.98E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:3.24|P-value:6.18E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.65|P-value:1.30E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.12|P-value:8.99E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.28|P-value:5.41E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.14|P-value:8.63E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.44|P-value:3.06E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.26|P-value:1.07E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:5.18|P-value:1.22E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.13|P-value:8.95E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.22|P-value:1.28E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.66|P-value:1.35E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.38|P-value:3.66E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.34|P-value:5.14E-8 ID:SGTC_890|Compound:0929-0006|FD-Score:4.58|P-value:2.49E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:4.91|P-value:4.93E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.82|P-value:7.45E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.10|P-value:9.79E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.84|P-value:6.54E-5 ID:SGTC_1658|Compound:st012944|FD-Score:4.29|P-value:9.38E-6 ID:SGTC_1671|Compound:st016596|FD-Score:3.57|P-value:1.86E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.58|P-value:2.42E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-3.87|P-value:5.50E-5 ID:SGTC_1940|Compound:st075990|FD-Score:4.43|P-value:5.11E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.77|P-value:8.37E-5 ID:SGTC_2007|Compound:4011539|FD-Score:3.77|P-value:8.46E-5 ID:SGTC_2046|Compound:4110841|FD-Score:4.72|P-value:1.29E-6 ID:SGTC_2051|Compound:5263410|FD-Score:3.37|P-value:3.96E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.00|P-value:3.39E-5 ID:SGTC_2065|Compound:5221596|FD-Score:-3.47|P-value:2.59E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.21|P-value:6.99E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.78|P-value:8.12E-5 ID:SGTC_2282|Compound:7944268|FD-Score:-3.71|P-value:1.05E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.67|P-value:1.52E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.36|P-value:4.01E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.43|P-value:5.01E-6 ID:SGTC_2451|Compound:5856223|FD-Score:3.75|P-value:9.44E-5 ID:SGTC_2481|Compound:5478948|FD-Score:4.56|P-value:2.75E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.85|P-value:6.12E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.81|P-value:7.11E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.23|P-value:6.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.29|P-value:5.01E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.47|P-value:2.69E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.45|P-value:4.61E-6 ID:SGTC_2817|Compound:7995342|FD-Score:4.11|P-value:2.05E-5 ID:SGTC_2923|Compound:7992654|FD-Score:3.79|P-value:7.86E-5 ID:SGTC_3083|Compound:9117465|FD-Score:4.35|P-value:7.19E-6 ID:SGTC_3141|Compound:9094609|FD-Score:3.13|P-value:9.04E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.48|P-value:3.99E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-4.69|P-value:1.38E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-4.85|P-value:6.35E-7 ID:SGTC_3209|Compound:9113616|FD-Score:4.41|P-value:5.41E-6 ID:SGTC_3233|Compound:9132340|FD-Score:3.34|P-value:4.36E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.82|P-value:7.04E-5 ID:SGTC_3247|Compound:9135149|FD-Score:3.57|P-value:1.90E-4 ID:SGTC_3254|Compound:9136651|FD-Score:5.16|P-value:1.37E-7 ID:SGTC_3258|Compound:9138477|FD-Score:4.26|P-value:1.10E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-4.05|P-value:2.60E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:3.36|P-value:4.02E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.28|P-value:5.40E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.32|P-value:4.66E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.96|P-value:3.92E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.28|P-value:5.42E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.14|P-value:8.91E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.44|P-value:3.03E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.64|P-value:1.85E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:5.67|P-value:7.81E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.89|P-value:1.97E-9 ID:SGTC_165|Compound:k038-0023|FD-Score:3.50|P-value:2.42E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.87|P-value:5.70E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.12|P-value:1.98E-5 ID:SGTC_263|Compound:alizarin|FD-Score:6.52|P-value:3.98E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:3.24|P-value:6.18E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.65|P-value:1.30E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.12|P-value:8.99E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.28|P-value:5.41E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.14|P-value:8.63E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.44|P-value:3.06E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.26|P-value:1.07E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:5.18|P-value:1.22E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.13|P-value:8.95E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.22|P-value:1.28E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.66|P-value:1.35E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.38|P-value:3.66E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.34|P-value:5.14E-8 ID:SGTC_890|Compound:0929-0006|FD-Score:4.58|P-value:2.49E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:4.91|P-value:4.93E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.82|P-value:7.45E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.10|P-value:9.79E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.84|P-value:6.54E-5 ID:SGTC_1658|Compound:st012944|FD-Score:4.29|P-value:9.38E-6 ID:SGTC_1671|Compound:st016596|FD-Score:3.57|P-value:1.86E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.58|P-value:2.42E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-3.87|P-value:5.50E-5 ID:SGTC_1940|Compound:st075990|FD-Score:4.43|P-value:5.11E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.77|P-value:8.37E-5 ID:SGTC_2007|Compound:4011539|FD-Score:3.77|P-value:8.46E-5 ID:SGTC_2046|Compound:4110841|FD-Score:4.72|P-value:1.29E-6 ID:SGTC_2051|Compound:5263410|FD-Score:3.37|P-value:3.96E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.00|P-value:3.39E-5 ID:SGTC_2065|Compound:5221596|FD-Score:-3.47|P-value:2.59E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.21|P-value:6.99E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.78|P-value:8.12E-5 ID:SGTC_2282|Compound:7944268|FD-Score:-3.71|P-value:1.05E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.67|P-value:1.52E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.36|P-value:4.01E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.43|P-value:5.01E-6 ID:SGTC_2451|Compound:5856223|FD-Score:3.75|P-value:9.44E-5 ID:SGTC_2481|Compound:5478948|FD-Score:4.56|P-value:2.75E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.85|P-value:6.12E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.81|P-value:7.11E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.23|P-value:6.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.29|P-value:5.01E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.47|P-value:2.69E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.45|P-value:4.61E-6 ID:SGTC_2817|Compound:7995342|FD-Score:4.11|P-value:2.05E-5 ID:SGTC_2923|Compound:7992654|FD-Score:3.79|P-value:7.86E-5 ID:SGTC_3083|Compound:9117465|FD-Score:4.35|P-value:7.19E-6 ID:SGTC_3141|Compound:9094609|FD-Score:3.13|P-value:9.04E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.48|P-value:3.99E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-4.69|P-value:1.38E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-4.85|P-value:6.35E-7 ID:SGTC_3209|Compound:9113616|FD-Score:4.41|P-value:5.41E-6 ID:SGTC_3233|Compound:9132340|FD-Score:3.34|P-value:4.36E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.82|P-value:7.04E-5 ID:SGTC_3247|Compound:9135149|FD-Score:3.57|P-value:1.90E-4 ID:SGTC_3254|Compound:9136651|FD-Score:5.16|P-value:1.37E-7 ID:SGTC_3258|Compound:9138477|FD-Score:4.26|P-value:1.10E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-4.05|P-value:2.60E-5

Top fitness defect scores for YPL139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_263 alizarin 6.52 107.9 µM 3.98E-11 iron homeostasis 21 3.54E-11
2 SGTC_158 k038-0087 5.67 26.4 µM 7.81E-9 ubiquinone biosynthesis & proteasome 73 7.12E-9
3 SGTC_829 1635-0120 5.34 117.0 µM 5.14E-8 DNA damage response 14 4.72E-8
4 SGTC_577 r071-0003 5.18 38.6 µM 1.22E-7 fatty acid desaturase (OLE1) 24 1.12E-7
5 SGTC_3254 9136651 5.16 49.5 µM 1.37E-7 DNA damage response 7 1.27E-7
6 SGTC_903 1134-0042 4.91 114.0 µM 4.93E-7 11 4.58E-7
7 SGTC_2046 4110841 4.72 106.0 µM 1.29E-6 iron homeostasis 15 1.20E-6
8 SGTC_142 0335-0849 4.64 62.7 µM 1.85E-6 ubiquinone biosynthesis & proteasome 97 1.73E-6
9 SGTC_890 0929-0006 4.58 47.2 µM 2.49E-6 10 2.33E-6
10 SGTC_2481 5478948 4.56 45.2 µM 2.75E-6 PDR1 22 2.58E-6
11 SGTC_3143 9086658 4.48 49.5 µM 3.99E-6 29 3.74E-6
12 SGTC_2797 7859098 4.45 81.8 µM 4.61E-6 21 4.33E-6
13 SGTC_2399 5884133 4.43 200.0 µM 5.01E-6 cell wall signaling 54 4.71E-6
14 SGTC_1940 st075990 4.43 51.1 µM 5.11E-6 60S ribosome export 12 4.80E-6
15 SGTC_3209 9113616 4.41 49.5 µM 5.41E-6 17 5.08E-6
16 SGTC_3083 9117465 4.35 49.5 µM 7.19E-6 9 6.77E-6
17 SGTC_1658 st012944 4.29 20.0 µM 9.38E-6 iron homeostasis 68 8.84E-6
18 SGTC_572 0960-0087 4.26 17.7 µM 1.07E-5 21 1.01E-5
19 SGTC_3258 9138477 4.26 49.5 µM 1.10E-5 5 1.04E-5
20 SGTC_737 1950-0117 4.22 57.9 µM 1.28E-5 18 1.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 2.26E-51 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.230 1.81E-41 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.221 2.27E-38 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.219 7.94E-38 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.204 5.97E-33 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.190 1.14E-28 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.189 2.27E-28 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.187 8.02E-28 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.186 1.41E-27 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.185 2.67E-27 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.184 5.39E-27 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.176 6.74E-25 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.174 2.68E-24 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.174 3.22E-24 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.173 4.58E-24 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron