YPL141C / FRK1

Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL141C / FRK1

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.15|P-value:6.94E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.30|P-value:4.13E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.50|P-value:1.95E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.30|P-value:4.10E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.23|P-value:5.25E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:7.11|P-value:2.65E-13 ID:SGTC_259|Compound:usnic acid|FD-Score:7.69|P-value:2.92E-15 ID:SGTC_264|Compound:promethazine|FD-Score:7.90|P-value:5.34E-16 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.26|P-value:7.56E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:5.00|P-value:1.98E-7 ID:SGTC_269|Compound:exalamide|FD-Score:4.13|P-value:1.40E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.36|P-value:3.32E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.20|P-value:5.92E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.27|P-value:4.64E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:5.81|P-value:1.89E-9 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.93|P-value:3.08E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.21|P-value:5.71E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.48|P-value:2.05E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-4.95|P-value:2.32E-7 ID:SGTC_909|Compound:3448-9333|FD-Score:3.19|P-value:6.18E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.08|P-value:1.24E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.39|P-value:2.76E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.10|P-value:8.00E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.30|P-value:3.77E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.72|P-value:8.15E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.79|P-value:6.00E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.13|P-value:7.44E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.70|P-value:8.88E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.37|P-value:3.16E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.16|P-value:6.69E-4 ID:SGTC_1848|Compound:st056003|FD-Score:4.26|P-value:7.79E-6 ID:SGTC_1920|Compound:st075728|FD-Score:3.20|P-value:5.90E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.79|P-value:5.99E-5 ID:SGTC_2031|Compound:5180455|FD-Score:4.15|P-value:1.25E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.75|P-value:7.25E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.82|P-value:4.96E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-3.22|P-value:5.15E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.53|P-value:1.71E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.67|P-value:9.94E-5 ID:SGTC_2165|Compound:5727197|FD-Score:6.02|P-value:5.05E-10 ID:SGTC_2242|Compound:6630449|FD-Score:-3.05|P-value:9.46E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.81|P-value:4.69E-7 ID:SGTC_2411|Compound:st077133|FD-Score:3.61|P-value:1.25E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.22|P-value:5.41E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:4.27|P-value:7.28E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.11|P-value:8.13E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.57|P-value:1.48E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.17|P-value:6.53E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.32|P-value:3.86E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.55|P-value:1.76E-6 ID:SGTC_2828|Compound:7998861|FD-Score:-3.17|P-value:6.17E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.05|P-value:9.97E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.31|P-value:3.65E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.59|P-value:1.36E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.12|P-value:7.35E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.15|P-value:6.94E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.30|P-value:4.13E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.50|P-value:1.95E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.30|P-value:4.10E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.23|P-value:5.25E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:7.11|P-value:2.65E-13 ID:SGTC_259|Compound:usnic acid|FD-Score:7.69|P-value:2.92E-15 ID:SGTC_264|Compound:promethazine|FD-Score:7.90|P-value:5.34E-16 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.26|P-value:7.56E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:5.00|P-value:1.98E-7 ID:SGTC_269|Compound:exalamide|FD-Score:4.13|P-value:1.40E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.36|P-value:3.32E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.20|P-value:5.92E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.27|P-value:4.64E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:5.81|P-value:1.89E-9 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.93|P-value:3.08E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.21|P-value:5.71E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.48|P-value:2.05E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-4.95|P-value:2.32E-7 ID:SGTC_909|Compound:3448-9333|FD-Score:3.19|P-value:6.18E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.08|P-value:1.24E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.39|P-value:2.76E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.10|P-value:8.00E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.30|P-value:3.77E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.72|P-value:8.15E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.79|P-value:6.00E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.13|P-value:7.44E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.70|P-value:8.88E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.37|P-value:3.16E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.16|P-value:6.69E-4 ID:SGTC_1848|Compound:st056003|FD-Score:4.26|P-value:7.79E-6 ID:SGTC_1920|Compound:st075728|FD-Score:3.20|P-value:5.90E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.79|P-value:5.99E-5 ID:SGTC_2031|Compound:5180455|FD-Score:4.15|P-value:1.25E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.75|P-value:7.25E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.82|P-value:4.96E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-3.22|P-value:5.15E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.53|P-value:1.71E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.67|P-value:9.94E-5 ID:SGTC_2165|Compound:5727197|FD-Score:6.02|P-value:5.05E-10 ID:SGTC_2242|Compound:6630449|FD-Score:-3.05|P-value:9.46E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.81|P-value:4.69E-7 ID:SGTC_2411|Compound:st077133|FD-Score:3.61|P-value:1.25E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.22|P-value:5.41E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:4.27|P-value:7.28E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.11|P-value:8.13E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.57|P-value:1.48E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.17|P-value:6.53E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.32|P-value:3.86E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.55|P-value:1.76E-6 ID:SGTC_2828|Compound:7998861|FD-Score:-3.17|P-value:6.17E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.05|P-value:9.97E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.31|P-value:3.65E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.59|P-value:1.36E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.12|P-value:7.35E-4

Top fitness defect scores for YPL141C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_264 promethazine 7.90 12.5 mM 5.34E-16 DNA intercalators 13 1.45E-15
2 SGTC_259 usnic acid 7.69 108.9 µM 2.92E-15 1 7.48E-15
3 SGTC_256 clotrimazole 7.11 625.0 nM 2.65E-13 ergosterol depletion effects on membrane 3 5.92E-13
4 SGTC_2165 5727197 6.02 32.1 µM 5.05E-10 13 8.92E-10
5 SGTC_694 1315-0438 5.81 43.2 µM 1.89E-9 2 3.20E-9
6 SGTC_920 mycophenolic acid 5.08 780.4 nM 1.24E-7 7 1.86E-7
7 SGTC_268 camptothecin 5.00 39.6 µM 1.98E-7 DNA damage response 49 2.93E-7
8 SGTC_2722 naftopidil 4.27 47.2 µM 7.28E-6 6 9.65E-6
9 SGTC_265 mycophenolic acid 4.26 32.9 µM 7.56E-6 RPP1 & pyrimidine depletion 9 1.00E-5
10 SGTC_1848 st056003 4.26 16.4 µM 7.79E-6 8 1.03E-5
11 SGTC_2031 5180455 4.15 200.0 µM 1.25E-5 9 1.63E-5
12 SGTC_269 exalamide 4.13 29.0 µM 1.40E-5 ergosterol biosynthesis 19 1.82E-5
13 SGTC_1954 st077032 3.79 68.9 µM 5.99E-5 25 7.47E-5
14 SGTC_1296 1068-0102 3.79 11.9 µM 6.00E-5 11 7.49E-5
15 SGTC_2042 p-Dimethylaminoacetophenone 3.75 200.0 µM 7.25E-5 25 8.99E-5
16 SGTC_1191 1487-1166 3.72 10.6 µM 8.15E-5 azole & statin 39 1.01E-4
17 SGTC_1395 3486-0190 3.70 4.3 µM 8.88E-5 21 1.10E-4
18 SGTC_2157 5649910 3.67 96.4 µM 9.94E-5 28 1.22E-4
19 SGTC_835 0312-0010 3.64 67.2 µM 1.09E-4 17 1.34E-4
20 SGTC_1926 methyl fluorone black 3.64 53.6 µM 1.11E-4 DNA intercalators 73 1.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 7.28E-20 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.153 5.77E-19 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.146 1.94E-17 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.144 6.14E-17 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.133 1.21E-14 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.124 4.64E-13 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.120 3.46E-12 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.119 5.70E-12 YJR001W AVT1 hom Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.109 2.96E-10 YOR121C_d YOR121C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
0.107 5.97E-10 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.105 1.19E-9 YPR178W PRP4 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.103 2.38E-9 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.101 4.88E-9 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.44E-8 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.097 1.59E-8 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex