YPL144W / POC4

Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL144W / POC4

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:-3.87|P-value:5.33E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.27|P-value:4.55E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:18.00|P-value:8.41E-74 ID:SGTC_86|Compound:0417-1630|FD-Score:5.50|P-value:1.25E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:6.40|P-value:4.73E-11 ID:SGTC_130|Compound:0136-0219|FD-Score:5.27|P-value:4.63E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:-7.07|P-value:6.19E-13 ID:SGTC_137|Compound:0438-0332|FD-Score:7.29|P-value:8.30E-14 ID:SGTC_142|Compound:0335-0849|FD-Score:3.85|P-value:4.74E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.07|P-value:9.08E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.24|P-value:4.96E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.34|P-value:3.48E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.28|P-value:5.12E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.35|P-value:3.99E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.36|P-value:6.34E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.58|P-value:1.73E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.24|P-value:8.44E-6 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.91|P-value:3.59E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.42|P-value:4.81E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.11|P-value:1.46E-7 ID:SGTC_627|Compound:1391-0720|FD-Score:-4.48|P-value:3.60E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:-4.99|P-value:2.79E-7 ID:SGTC_631|Compound:k072-0230|FD-Score:4.32|P-value:6.02E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:7.35|P-value:5.05E-14 ID:SGTC_888|Compound:0916-0002|FD-Score:3.11|P-value:7.78E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.53|P-value:2.10E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.50|P-value:2.29E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.32|P-value:3.68E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.75|P-value:7.41E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.79|P-value:5.90E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:5.27|P-value:4.57E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.10|P-value:9.83E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.64|P-value:1.10E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.67|P-value:1.11E-6 ID:SGTC_1610|Compound:st001799|FD-Score:3.26|P-value:4.65E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.96|P-value:2.88E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-8.03|P-value:3.54E-16 ID:SGTC_1763|Compound:st044482|FD-Score:5.13|P-value:9.86E-8 ID:SGTC_1764|Compound:st044502|FD-Score:-6.43|P-value:5.26E-11 ID:SGTC_1854|Compound:st056233|FD-Score:5.14|P-value:9.69E-8 ID:SGTC_1941|Compound:st076221|FD-Score:-3.44|P-value:2.93E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.46|P-value:2.18E-4 ID:SGTC_2139|Compound:5578692|FD-Score:5.19|P-value:7.15E-8 ID:SGTC_2167|Compound:5876490|FD-Score:3.07|P-value:9.01E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.96|P-value:2.88E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.79|P-value:6.00E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.30|P-value:4.77E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.53|P-value:2.88E-6 ID:SGTC_2294|Compound:7971431|FD-Score:-4.01|P-value:2.94E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.11|P-value:7.97E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.73|P-value:7.51E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-5.22|P-value:8.30E-8 ID:SGTC_2424|Compound:5537928|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.99|P-value:2.17E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.61|P-value:1.53E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.05|P-value:9.79E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.93|P-value:3.36E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.69|P-value:8.92E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-4.55|P-value:2.59E-6 ID:SGTC_2840|Compound:9008771|FD-Score:4.77|P-value:6.61E-7 ID:SGTC_2843|Compound:9000894|FD-Score:4.33|P-value:5.58E-6 ID:SGTC_2847|Compound:9005661|FD-Score:5.57|P-value:8.41E-9 ID:SGTC_2866|Compound:9034245|FD-Score:3.12|P-value:7.66E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.17|P-value:6.41E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.21|P-value:5.44E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.24|P-value:4.93E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:-3.87|P-value:5.33E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.27|P-value:4.55E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:18.00|P-value:8.41E-74 ID:SGTC_86|Compound:0417-1630|FD-Score:5.50|P-value:1.25E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:6.40|P-value:4.73E-11 ID:SGTC_130|Compound:0136-0219|FD-Score:5.27|P-value:4.63E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:-7.07|P-value:6.19E-13 ID:SGTC_137|Compound:0438-0332|FD-Score:7.29|P-value:8.30E-14 ID:SGTC_142|Compound:0335-0849|FD-Score:3.85|P-value:4.74E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.07|P-value:9.08E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.24|P-value:4.96E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.34|P-value:3.48E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.28|P-value:5.12E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.35|P-value:3.99E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.36|P-value:6.34E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.58|P-value:1.73E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.24|P-value:8.44E-6 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.91|P-value:3.59E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.42|P-value:4.81E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.11|P-value:1.46E-7 ID:SGTC_627|Compound:1391-0720|FD-Score:-4.48|P-value:3.60E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:-4.99|P-value:2.79E-7 ID:SGTC_631|Compound:k072-0230|FD-Score:4.32|P-value:6.02E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:7.35|P-value:5.05E-14 ID:SGTC_888|Compound:0916-0002|FD-Score:3.11|P-value:7.78E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.53|P-value:2.10E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.50|P-value:2.29E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.32|P-value:3.68E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.75|P-value:7.41E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.79|P-value:5.90E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:5.27|P-value:4.57E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.10|P-value:9.83E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.64|P-value:1.10E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.67|P-value:1.11E-6 ID:SGTC_1610|Compound:st001799|FD-Score:3.26|P-value:4.65E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.96|P-value:2.88E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-8.03|P-value:3.54E-16 ID:SGTC_1763|Compound:st044482|FD-Score:5.13|P-value:9.86E-8 ID:SGTC_1764|Compound:st044502|FD-Score:-6.43|P-value:5.26E-11 ID:SGTC_1854|Compound:st056233|FD-Score:5.14|P-value:9.69E-8 ID:SGTC_1941|Compound:st076221|FD-Score:-3.44|P-value:2.93E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.46|P-value:2.18E-4 ID:SGTC_2139|Compound:5578692|FD-Score:5.19|P-value:7.15E-8 ID:SGTC_2167|Compound:5876490|FD-Score:3.07|P-value:9.01E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.96|P-value:2.88E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.79|P-value:6.00E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.30|P-value:4.77E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.53|P-value:2.88E-6 ID:SGTC_2294|Compound:7971431|FD-Score:-4.01|P-value:2.94E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.11|P-value:7.97E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.73|P-value:7.51E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-5.22|P-value:8.30E-8 ID:SGTC_2424|Compound:5537928|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.99|P-value:2.17E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.61|P-value:1.53E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.05|P-value:9.79E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.93|P-value:3.36E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.69|P-value:8.92E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-4.55|P-value:2.59E-6 ID:SGTC_2840|Compound:9008771|FD-Score:4.77|P-value:6.61E-7 ID:SGTC_2843|Compound:9000894|FD-Score:4.33|P-value:5.58E-6 ID:SGTC_2847|Compound:9005661|FD-Score:5.57|P-value:8.41E-9 ID:SGTC_2866|Compound:9034245|FD-Score:3.12|P-value:7.66E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.17|P-value:6.41E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.21|P-value:5.44E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.24|P-value:4.93E-4

Top fitness defect scores for YPL144W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 18.00 272.1 µM 8.41E-74 ubiquinone biosynthesis & proteasome 14 1.83E-72
2 SGTC_745 0469-0705 7.35 296.0 µM 5.05E-14 mitochondrial processes 1 9.60E-14
3 SGTC_137 0438-0332 7.29 85.4 µM 8.30E-14 ubiquinone biosynthesis & proteasome 47 1.56E-13
4 SGTC_103 0844-0104 6.40 51.8 µM 4.73E-11 ERAD & cell cycle 69 7.89E-11
5 SGTC_2847 9005661 5.57 71.4 µM 8.41E-9 3 1.27E-8
6 SGTC_86 0417-1630 5.50 471.9 µM 1.25E-8 ubiquinone biosynthesis & proteasome 99 1.88E-8
7 SGTC_58 0957-0393 5.27 9.0 µM 4.55E-8 cell wall 259 6.64E-8
8 SGTC_1136 pergolide 5.27 1.1 µM 4.57E-8 10 6.66E-8
9 SGTC_130 0136-0219 5.27 337.7 µM 4.63E-8 8 6.75E-8
10 SGTC_2139 5578692 5.19 56.5 µM 7.15E-8 superoxide 7 1.03E-7
11 SGTC_1854 st056233 5.14 32.9 µM 9.69E-8 amide catabolism 8 1.39E-7
12 SGTC_1763 st044482 5.13 94.5 µM 9.86E-8 copper-dependent oxidative stress 9 1.42E-7
13 SGTC_2688 kanamycin b 4.99 96.7 µM 2.17E-7 calcium & mitochondrial duress 246 3.07E-7
14 SGTC_2840 9008771 4.77 71.4 µM 6.61E-7 4 9.14E-7
15 SGTC_1047 2043-3044 4.75 82.0 µM 7.41E-7 19 1.02E-6
16 SGTC_1426 4048-4480 4.67 71.7 µM 1.11E-6 60S ribosome export 8 1.52E-6
17 SGTC_2843 9000894 4.33 45.5 µM 5.58E-6 8 7.38E-6
18 SGTC_631 k072-0230 4.32 41.5 µM 6.02E-6 60S ribosome export 12 7.96E-6
19 SGTC_353 1988-1175 4.24 58.3 µM 8.44E-6 unfolded protein response 20 1.11E-5
20 SGTC_2250 alverine citrate 3.96 130.0 µM 2.88E-5 154 3.68E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.355 2.82E-100 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.318 1.09E-79 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.313 5.24E-77 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.309 3.63E-75 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.303 3.73E-72 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.296 8.79E-69 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.292 6.96E-67 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.289 2.15E-65 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.285 8.79E-64 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.280 1.36E-61 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.280 2.59E-61 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.279 6.02E-61 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.277 2.81E-60 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.273 1.90E-58 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.268 3.72E-56 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress