YPL148C / PPT2

Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL148C / PPT2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.73|P-value:2.79E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:8.67|P-value:3.23E-12 ID:SGTC_37|Compound:0566-0070|FD-Score:8.74|P-value:2.16E-12 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.81|P-value:3.36E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:5.61|P-value:4.32E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.51|P-value:1.80E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:7.31|P-value:3.40E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:7.42|P-value:2.05E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:5.05|P-value:3.19E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.24|P-value:3.95E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.92|P-value:4.88E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:26.20|P-value:2.00E-96 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.40|P-value:2.43E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.80|P-value:3.52E-28 ID:SGTC_310|Compound:1273-0058|FD-Score:4.75|P-value:8.35E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.09|P-value:6.00E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:9.92|P-value:1.82E-15 ID:SGTC_430|Compound:0958-0115|FD-Score:4.03|P-value:7.07E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.99|P-value:7.89E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-4.16|P-value:4.70E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.49|P-value:1.86E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.73|P-value:9.06E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.17|P-value:2.13E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:5.55|P-value:5.52E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.98|P-value:8.22E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.49|P-value:1.87E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.94|P-value:8.95E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:5.11|P-value:2.58E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.38|P-value:1.03E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.19|P-value:1.96E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:-9.60|P-value:1.25E-14 ID:SGTC_1248|Compound:0469-0687|FD-Score:-9.45|P-value:3.02E-14 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.43|P-value:2.12E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.12|P-value:5.56E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.55|P-value:5.56E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.34|P-value:2.96E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.85|P-value:2.80E-8 ID:SGTC_1636|Compound:st007707|FD-Score:-4.70|P-value:9.39E-5 ID:SGTC_1648|Compound:st011736|FD-Score:4.29|P-value:3.37E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.12|P-value:5.33E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.89|P-value:1.45E-6 ID:SGTC_1827|Compound:berberine|FD-Score:4.41|P-value:2.37E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-5.12|P-value:2.34E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.03|P-value:3.42E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-4.73|P-value:8.62E-5 ID:SGTC_2043|Compound:5101342|FD-Score:4.25|P-value:3.87E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.49|P-value:1.88E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.03|P-value:7.18E-4 ID:SGTC_2132|Compound:5317594|FD-Score:4.28|P-value:3.52E-4 ID:SGTC_2224|Compound:6650123|FD-Score:3.90|P-value:9.99E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.96|P-value:8.50E-4 ID:SGTC_2287|Compound:7945887|FD-Score:6.82|P-value:3.23E-8 ID:SGTC_2404|Compound:5161160|FD-Score:4.75|P-value:8.38E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.25|P-value:1.61E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.90|P-value:5.11E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.97|P-value:8.40E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.56|P-value:1.45E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.21|P-value:4.06E-7 ID:SGTC_2914|Compound:7968218|FD-Score:-4.59|P-value:1.33E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.16|P-value:4.97E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-4.16|P-value:4.68E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-4.13|P-value:5.16E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.80|P-value:6.83E-5 ID:SGTC_3102|Compound:9121669|FD-Score:4.14|P-value:5.25E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-5.21|P-value:1.71E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-6.68|P-value:5.65E-8 ID:SGTC_3323|Compound:9138564|FD-Score:4.84|P-value:6.33E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:5.73|P-value:2.79E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:8.67|P-value:3.23E-12 ID:SGTC_37|Compound:0566-0070|FD-Score:8.74|P-value:2.16E-12 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.81|P-value:3.36E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:5.61|P-value:4.32E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.51|P-value:1.80E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:7.31|P-value:3.40E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:7.42|P-value:2.05E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:5.05|P-value:3.19E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.24|P-value:3.95E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.92|P-value:4.88E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:26.20|P-value:2.00E-96 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.40|P-value:2.43E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.80|P-value:3.52E-28 ID:SGTC_310|Compound:1273-0058|FD-Score:4.75|P-value:8.35E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.09|P-value:6.00E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:9.92|P-value:1.82E-15 ID:SGTC_430|Compound:0958-0115|FD-Score:4.03|P-value:7.07E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.99|P-value:7.89E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-4.16|P-value:4.70E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.49|P-value:1.86E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.73|P-value:9.06E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.17|P-value:2.13E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:5.55|P-value:5.52E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.98|P-value:8.22E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.49|P-value:1.87E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.94|P-value:8.95E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:5.11|P-value:2.58E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.38|P-value:1.03E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.19|P-value:1.96E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:-9.60|P-value:1.25E-14 ID:SGTC_1248|Compound:0469-0687|FD-Score:-9.45|P-value:3.02E-14 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.43|P-value:2.12E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.12|P-value:5.56E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.55|P-value:5.56E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.34|P-value:2.96E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.85|P-value:2.80E-8 ID:SGTC_1636|Compound:st007707|FD-Score:-4.70|P-value:9.39E-5 ID:SGTC_1648|Compound:st011736|FD-Score:4.29|P-value:3.37E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.12|P-value:5.33E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.89|P-value:1.45E-6 ID:SGTC_1827|Compound:berberine|FD-Score:4.41|P-value:2.37E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-5.12|P-value:2.34E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.03|P-value:3.42E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-4.73|P-value:8.62E-5 ID:SGTC_2043|Compound:5101342|FD-Score:4.25|P-value:3.87E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.49|P-value:1.88E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.03|P-value:7.18E-4 ID:SGTC_2132|Compound:5317594|FD-Score:4.28|P-value:3.52E-4 ID:SGTC_2224|Compound:6650123|FD-Score:3.90|P-value:9.99E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.96|P-value:8.50E-4 ID:SGTC_2287|Compound:7945887|FD-Score:6.82|P-value:3.23E-8 ID:SGTC_2404|Compound:5161160|FD-Score:4.75|P-value:8.38E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.25|P-value:1.61E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.90|P-value:5.11E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.97|P-value:8.40E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.56|P-value:1.45E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.21|P-value:4.06E-7 ID:SGTC_2914|Compound:7968218|FD-Score:-4.59|P-value:1.33E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.16|P-value:4.97E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-4.16|P-value:4.68E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-4.13|P-value:5.16E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.80|P-value:6.83E-5 ID:SGTC_3102|Compound:9121669|FD-Score:4.14|P-value:5.25E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-5.21|P-value:1.71E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-6.68|P-value:5.65E-8 ID:SGTC_3323|Compound:9138564|FD-Score:4.84|P-value:6.33E-5

Top fitness defect scores for YPL148C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 26.20 5.3 µM 2.00E-96 28 6.73E-152
2 SGTC_275 trichlorophene 13.80 5.7 µM 3.52E-28 mitochondrial stress 12 1.25E-43
3 SGTC_386 1509-0011 9.92 3.1 µM 1.82E-15 45 1.66E-23
4 SGTC_37 0566-0070 8.74 1.6 µM 2.16E-12 3 1.19E-18
5 SGTC_36 0335-0881 8.67 14.2 µM 3.23E-12 ubiquinone biosynthesis & proteasome 30 2.25E-18
6 SGTC_134 0269-0018 7.42 6.9 µM 2.05E-9 63 5.93E-14
7 SGTC_119 0121-0043 7.31 24.8 µM 3.40E-9 mitochondrial stress 12 1.31E-13
8 SGTC_1635 st007035 6.85 42.4 µM 2.80E-8 122 3.61E-12
9 SGTC_2287 7945887 6.82 168.8 µM 3.23E-8 1 4.53E-12
10 SGTC_46 0329-0187a 6.81 2.2 µM 3.36E-8 19 4.81E-12
11 SGTC_10 0279-0212 5.73 42.6 µM 2.79E-6 TRP & mitochondrial translation 33 4.95E-9
12 SGTC_70 0141-0289 5.61 43.3 µM 4.32E-6 mitochondrial stress 93 9.85E-9
13 SGTC_970 1315-0089 5.55 19.5 µM 5.52E-6 RSC & ERG11 5 1.44E-8
14 SGTC_1319 1306-0155 5.55 43.7 µM 5.56E-6 3 1.46E-8
15 SGTC_1113 artemisinin 5.38 1.2 µM 1.03E-5 heme biosynthesis & mitochondrial translocase 7 3.80E-8
16 SGTC_2408 sulbentine 5.25 18.4 µM 1.61E-5 27 7.69E-8
17 SGTC_1188 1403-0014 5.19 4.6 µM 1.96E-5 mitochondrial stress 24 1.05E-7
18 SGTC_908 3448-7491 5.17 47.7 µM 2.13E-5 mitochondrial stress 73 1.19E-7
19 SGTC_1109 tnp00067 5.11 928.3 nM 2.58E-5 3 1.61E-7
20 SGTC_173 1273-0061 5.05 2.7 µM 3.19E-5 mitochondrial stress 145 2.24E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.530 2.99E-242 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.514 5.70E-226 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.511 2.20E-222 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.495 1.85E-207 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.491 4.91E-203 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.486 6.66E-199 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.471 8.85E-185 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.456 1.09E-171 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.455 1.65E-171 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.455 7.99E-171 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.448 6.23E-165 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.447 1.18E-164 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.442 1.41E-160 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.439 5.77E-158 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.438 5.20E-157 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit