YPL149W / ATG5

Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL149W / ATG5

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.81|P-value:2.28E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.09|P-value:4.64E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:2.89|P-value:9.83E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.13|P-value:4.00E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.27|P-value:2.34E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-5.97|P-value:1.05E-10 ID:SGTC_162|Compound:k030-0015|FD-Score:-4.09|P-value:6.71E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.49|P-value:1.02E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.34|P-value:1.72E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:2.95|P-value:7.78E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.11|P-value:4.26E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:5.12|P-value:2.14E-8 ID:SGTC_631|Compound:k072-0230|FD-Score:4.60|P-value:4.27E-7 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.25|P-value:2.74E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.51|P-value:8.65E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:-2.97|P-value:8.06E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.45|P-value:1.13E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.98|P-value:1.03E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.91|P-value:1.43E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.76|P-value:1.81E-7 ID:SGTC_1725|Compound:st036284|FD-Score:-3.40|P-value:1.51E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.04|P-value:5.76E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.93|P-value:8.47E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.66|P-value:4.94E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.15|P-value:3.77E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.97|P-value:7.25E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.86|P-value:2.03E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.48|P-value:9.73E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.31|P-value:1.99E-6 ID:SGTC_2219|Compound:9098279|FD-Score:3.32|P-value:1.91E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.54|P-value:6.13E-7 ID:SGTC_2288|Compound:7946289|FD-Score:3.54|P-value:7.47E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.59|P-value:6.03E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.03|P-value:5.96E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:2.89|P-value:9.69E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.99|P-value:4.70E-8 ID:SGTC_2771|Compound:fluoxetine|FD-Score:6.27|P-value:1.03E-11 ID:SGTC_2783|Compound:7738165|FD-Score:2.92|P-value:8.77E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.55|P-value:8.16E-5 ID:SGTC_2871|Compound:9038510|FD-Score:-3.02|P-value:6.53E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-4.94|P-value:7.40E-8 ID:SGTC_3018|Compound:9082602|FD-Score:3.80|P-value:2.42E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.91|P-value:1.41E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.47|P-value:8.56E-7 ID:SGTC_3142|Compound:9086498|FD-Score:5.64|P-value:8.31E-10 ID:SGTC_3195|Compound:9113082|FD-Score:2.98|P-value:7.15E-4 ID:SGTC_3197|Compound:9113331|FD-Score:2.96|P-value:7.50E-4 ID:SGTC_3204|Compound:9114183|FD-Score:6.48|P-value:2.12E-12 ID:SGTC_49|Compound:0717-0965|FD-Score:3.81|P-value:2.28E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.09|P-value:4.64E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:2.89|P-value:9.83E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.13|P-value:4.00E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.27|P-value:2.34E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-5.97|P-value:1.05E-10 ID:SGTC_162|Compound:k030-0015|FD-Score:-4.09|P-value:6.71E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.49|P-value:1.02E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.34|P-value:1.72E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:2.95|P-value:7.78E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.11|P-value:4.26E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:5.12|P-value:2.14E-8 ID:SGTC_631|Compound:k072-0230|FD-Score:4.60|P-value:4.27E-7 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.25|P-value:2.74E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.51|P-value:8.65E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:-2.97|P-value:8.06E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.45|P-value:1.13E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.98|P-value:1.03E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.91|P-value:1.43E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.76|P-value:1.81E-7 ID:SGTC_1725|Compound:st036284|FD-Score:-3.40|P-value:1.51E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.04|P-value:5.76E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.93|P-value:8.47E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.66|P-value:4.94E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.15|P-value:3.77E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.97|P-value:7.25E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.86|P-value:2.03E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.48|P-value:9.73E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.31|P-value:1.99E-6 ID:SGTC_2219|Compound:9098279|FD-Score:3.32|P-value:1.91E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.54|P-value:6.13E-7 ID:SGTC_2288|Compound:7946289|FD-Score:3.54|P-value:7.47E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.59|P-value:6.03E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.03|P-value:5.96E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:2.89|P-value:9.69E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.99|P-value:4.70E-8 ID:SGTC_2771|Compound:fluoxetine|FD-Score:6.27|P-value:1.03E-11 ID:SGTC_2783|Compound:7738165|FD-Score:2.92|P-value:8.77E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.55|P-value:8.16E-5 ID:SGTC_2871|Compound:9038510|FD-Score:-3.02|P-value:6.53E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-4.94|P-value:7.40E-8 ID:SGTC_3018|Compound:9082602|FD-Score:3.80|P-value:2.42E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.91|P-value:1.41E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.47|P-value:8.56E-7 ID:SGTC_3142|Compound:9086498|FD-Score:5.64|P-value:8.31E-10 ID:SGTC_3195|Compound:9113082|FD-Score:2.98|P-value:7.15E-4 ID:SGTC_3197|Compound:9113331|FD-Score:2.96|P-value:7.50E-4 ID:SGTC_3204|Compound:9114183|FD-Score:6.48|P-value:2.12E-12

Top fitness defect scores for YPL149W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3204 9114183 6.48 49.5 µM 2.12E-12 7 4.49E-11
2 SGTC_2771 fluoxetine 6.27 41.0 µM 1.03E-11 3 1.81E-10
3 SGTC_3142 9086498 5.64 49.5 µM 8.31E-10 iron homeostasis 11 8.57E-9
4 SGTC_588 3970-1144 5.12 52.9 µM 2.14E-8 9 1.50E-7
5 SGTC_2767 sibutramine 4.99 71.5 µM 4.70E-8 7 2.99E-7
6 SGTC_1212 0520-0165 4.76 585.0 µM 1.81E-7 11 9.80E-7
7 SGTC_631 k072-0230 4.60 41.5 µM 4.27E-7 60S ribosome export 5 2.09E-6
8 SGTC_2247 cerulenin 4.54 830.0 nM 6.13E-7 9 2.87E-6
9 SGTC_3081 9117243 4.47 49.5 µM 8.56E-7 fatty acid desaturase (OLE1) 13 3.85E-6
10 SGTC_2184 6075246 4.31 200.0 µM 1.99E-6 17 8.11E-6
11 SGTC_1150 3909-7983 3.98 10.9 µM 1.03E-5 22 3.44E-5
12 SGTC_3067 9117431 3.91 49.5 µM 1.41E-5 9 4.55E-5
13 SGTC_1171 0368-0077 3.91 21.4 µM 1.43E-5 21 4.60E-5
14 SGTC_49 0717-0965 3.81 32.1 µM 2.28E-5 60S ribosome export 23 6.93E-5
15 SGTC_3018 9082602 3.80 49.5 µM 2.42E-5 52 7.32E-5
16 SGTC_2311 7694451 3.59 200.0 µM 6.03E-5 31 1.64E-4
17 SGTC_2288 7946289 3.54 167.3 µM 7.47E-5 40 1.98E-4
18 SGTC_843 0310-0051 3.51 143.0 µM 8.65E-5 22 2.25E-4
19 SGTC_2179 6298986 3.48 200.0 µM 9.73E-5 heme requiring 29 2.50E-4
20 SGTC_1011 4112-3381 3.45 17.4 µM 1.13E-4 62 2.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.93E-10 YPR149W NCE102 hom Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
0.107 4.88E-10 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.101 4.03E-9 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.092 1.00E-7 YKL043W PHD1 hom Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication
0.089 2.53E-7 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.088 3.22E-7 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.088 3.26E-7 YNR024W MPP6 hom Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes
0.088 3.26E-7 YGL153W PEX14 hom Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
0.088 3.60E-7 YJL126W NIT2 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.087 4.04E-7 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
0.086 5.41E-7 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.086 6.94E-7 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.085 8.22E-7 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.085 8.82E-7 YHR143W DSE2 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
0.084 1.26E-6 YCR102C_p YCR102C_p hom Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family