YPL151C / PRP46

Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL151C / PRP46

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.34|P-value:4.20E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:2.81|P-value:4.66E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-2.82|P-value:5.85E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.36|P-value:3.89E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.83|P-value:3.40E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:2.68|P-value:7.92E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.45|P-value:2.43E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:2.63|P-value:9.70E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.58|P-value:1.72E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-2.80|P-value:6.36E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:2.70|P-value:7.31E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.15|P-value:1.39E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:4.30|P-value:2.24E-7 ID:SGTC_876|Compound:0720-0963|FD-Score:3.17|P-value:9.57E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:3.58|P-value:1.25E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.56|P-value:1.42E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.75|P-value:6.05E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-4.84|P-value:1.05E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:2.66|P-value:8.45E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.06|P-value:2.11E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.16|P-value:1.30E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.42|P-value:3.97E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.05|P-value:2.14E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.70|P-value:9.22E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.00|P-value:2.01E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.75|P-value:7.68E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:2.75|P-value:5.93E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-2.73|P-value:8.15E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-2.80|P-value:6.25E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:2.71|P-value:6.92E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.76|P-value:7.26E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.79|P-value:6.59E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.23|P-value:7.21E-5 ID:SGTC_1694|Compound:st024011|FD-Score:3.37|P-value:3.64E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.44|P-value:3.58E-5 ID:SGTC_1776|Compound:st049249|FD-Score:-2.84|P-value:5.30E-4 ID:SGTC_1827|Compound:berberine|FD-Score:2.69|P-value:7.72E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-4.28|P-value:3.71E-7 ID:SGTC_1840|Compound:st055363|FD-Score:-2.69|P-value:9.59E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.09|P-value:1.80E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.02|P-value:2.43E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.35|P-value:3.97E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.11|P-value:6.94E-7 ID:SGTC_2329|Compound:6138490|FD-Score:-4.02|P-value:1.66E-6 ID:SGTC_2362|Compound:9071156|FD-Score:3.60|P-value:1.19E-5 ID:SGTC_2469|Compound:5655019|FD-Score:2.79|P-value:4.97E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:9.83|P-value:7.14E-31 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.91|P-value:3.04E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.42|P-value:3.89E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:3.71|P-value:6.67E-6 ID:SGTC_2657|Compound:nystatin|FD-Score:-2.70|P-value:9.49E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-2.86|P-value:4.85E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-2.79|P-value:6.56E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:-2.80|P-value:6.24E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.41|P-value:3.01E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:-2.87|P-value:4.67E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.79|P-value:4.13E-6 ID:SGTC_2802|Compound:7925815|FD-Score:-2.81|P-value:6.10E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.59|P-value:1.64E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-2.83|P-value:5.49E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.63|P-value:1.35E-5 ID:SGTC_2855|Compound:9016525|FD-Score:2.97|P-value:2.37E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.17|P-value:1.24E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.35|P-value:4.13E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.50|P-value:6.63E-8 ID:SGTC_3138|Compound:9097216|FD-Score:-4.16|P-value:7.41E-7 ID:SGTC_3272|Compound:9137413|FD-Score:2.65|P-value:8.92E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.34|P-value:4.20E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:2.81|P-value:4.66E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-2.82|P-value:5.85E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.36|P-value:3.89E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.83|P-value:3.40E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:2.68|P-value:7.92E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.45|P-value:2.43E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:2.63|P-value:9.70E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.58|P-value:1.72E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-2.80|P-value:6.36E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:2.70|P-value:7.31E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.15|P-value:1.39E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:4.30|P-value:2.24E-7 ID:SGTC_876|Compound:0720-0963|FD-Score:3.17|P-value:9.57E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:3.58|P-value:1.25E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.56|P-value:1.42E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.75|P-value:6.05E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-4.84|P-value:1.05E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:2.66|P-value:8.45E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.06|P-value:2.11E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.16|P-value:1.30E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.42|P-value:3.97E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.05|P-value:2.14E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.70|P-value:9.22E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.00|P-value:2.01E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.75|P-value:7.68E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:2.75|P-value:5.93E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-2.73|P-value:8.15E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-2.80|P-value:6.25E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:2.71|P-value:6.92E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.76|P-value:7.26E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.79|P-value:6.59E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.23|P-value:7.21E-5 ID:SGTC_1694|Compound:st024011|FD-Score:3.37|P-value:3.64E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.44|P-value:3.58E-5 ID:SGTC_1776|Compound:st049249|FD-Score:-2.84|P-value:5.30E-4 ID:SGTC_1827|Compound:berberine|FD-Score:2.69|P-value:7.72E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-4.28|P-value:3.71E-7 ID:SGTC_1840|Compound:st055363|FD-Score:-2.69|P-value:9.59E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.09|P-value:1.80E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.02|P-value:2.43E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.35|P-value:3.97E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.11|P-value:6.94E-7 ID:SGTC_2329|Compound:6138490|FD-Score:-4.02|P-value:1.66E-6 ID:SGTC_2362|Compound:9071156|FD-Score:3.60|P-value:1.19E-5 ID:SGTC_2469|Compound:5655019|FD-Score:2.79|P-value:4.97E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:9.83|P-value:7.14E-31 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.91|P-value:3.04E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.42|P-value:3.89E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:3.71|P-value:6.67E-6 ID:SGTC_2657|Compound:nystatin|FD-Score:-2.70|P-value:9.49E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-2.86|P-value:4.85E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-2.79|P-value:6.56E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:-2.80|P-value:6.24E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.41|P-value:3.01E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:-2.87|P-value:4.67E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.79|P-value:4.13E-6 ID:SGTC_2802|Compound:7925815|FD-Score:-2.81|P-value:6.10E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.59|P-value:1.64E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-2.83|P-value:5.49E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.63|P-value:1.35E-5 ID:SGTC_2855|Compound:9016525|FD-Score:2.97|P-value:2.37E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.17|P-value:1.24E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.35|P-value:4.13E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.50|P-value:6.63E-8 ID:SGTC_3138|Compound:9097216|FD-Score:-4.16|P-value:7.41E-7 ID:SGTC_3272|Compound:9137413|FD-Score:2.65|P-value:8.92E-4

Top fitness defect scores for YPL151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2620 irigenin 9.83 100.0 µM 7.14E-31 1 4.19E-23 1.87
2 SGTC_2998 9066762 4.50 71.4 µM 6.63E-8 RPP1 & pyrimidine depletion 6 3.48E-6 0.12
3 SGTC_845 0330-0138 4.30 4.5 µM 2.24E-7 7 8.55E-6 0.74
4 SGTC_2131 toluylene red 4.11 5.3 µM 6.94E-7 60S ribosome export 14 1.97E-5 0.13
5 SGTC_129 0088-0017 3.83 176.6 µM 3.40E-6 5 6.41E-5 0.02
6 SGTC_2768 sulfasalazine 3.79 50.2 µM 4.13E-6 13 7.40E-5 0.04
7 SGTC_2645 abamectin 3.71 100.0 µM 6.67E-6 heme requiring 15 1.06E-4 0.09
8 SGTC_2362 9071156 3.60 126.0 µM 1.19E-5 6 1.62E-4 0.23
9 SGTC_883 0850-0245 3.58 24.6 µM 1.25E-5 cell wall 10 1.69E-4 0.27
10 SGTC_996 3970-0799 3.56 1.8 µM 1.42E-5 23 1.85E-4 0.01
11 SGTC_135 0933-0004 3.45 26.4 µM 2.43E-5 60S ribosome export 11 2.76E-4 0.07
12 SGTC_2678 equilin 3.41 100.0 µM 3.01E-5 3 3.23E-4 0.31
13 SGTC_1694 st024011 3.37 44.9 µM 3.64E-5 ERG2 14 3.72E-4 0.04
14 SGTC_79 0052-0007 3.36 94.1 µM 3.89E-5 5 3.91E-4 0.05
15 SGTC_1927 st060202 3.35 13.8 µM 3.97E-5 11 3.97E-4 0.04
16 SGTC_2988 9073640 3.35 71.4 µM 4.13E-5 18 4.09E-4 0.05
17 SGTC_6 0844-0013 3.34 19.8 µM 4.20E-5 20 4.14E-4 0.03
18 SGTC_1677 st019204 3.23 53.9 µM 7.21E-5 16 6.18E-4 0.01
19 SGTC_876 0720-0963 3.17 56.8 µM 9.57E-5 13 7.63E-4 0.23
20 SGTC_1209 2323-2347 3.00 50.3 µM 2.01E-4 11 0.00133 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.14E-15 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.137 1.90E-15 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.125 3.65E-13 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.118 7.51E-12 YOR371C GPB1 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication
0.114 3.12E-11 YJL087C TRL1 het tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes
0.110 1.99E-10 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.107 4.27E-10 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.105 1.03E-9 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
0.105 1.17E-9 YOL139C CDC33 het mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
0.103 1.86E-9 YOR336W KRE5 het Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
0.101 4.55E-9 YLR182W SWI6 hom Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators
0.098 1.46E-8 YLR329W REC102 hom Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.098 1.58E-8 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.097 1.73E-8 YML018C YML018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication
0.094 4.89E-8 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study