YPL152W / RRD2

Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL152W / RRD2

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.07|P-value:9.87E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.56|P-value:2.69E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.42|P-value:2.90E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.36|P-value:3.67E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.12|P-value:8.38E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.33|P-value:7.21E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:3.72|P-value:9.26E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-4.24|P-value:1.77E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:6.95|P-value:2.13E-12 ID:SGTC_435|Compound:c-PAF|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.11|P-value:5.46E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.75|P-value:9.78E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:4.30|P-value:8.08E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:4.62|P-value:1.83E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:4.18|P-value:1.37E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:-4.03|P-value:4.32E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:5.57|P-value:1.32E-8 ID:SGTC_559|Compound:1550-0661|FD-Score:3.67|P-value:1.12E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.83|P-value:9.57E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.57|P-value:2.55E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.40|P-value:3.12E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.77|P-value:7.72E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.72|P-value:1.49E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-4.29|P-value:1.46E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:5.71|P-value:5.83E-9 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.60|P-value:2.35E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.16|P-value:7.22E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.17|P-value:7.11E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.41|P-value:4.98E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.33|P-value:6.10E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.34|P-value:5.95E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.14|P-value:1.69E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.90|P-value:4.49E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.93|P-value:4.07E-5 ID:SGTC_1801|Compound:st050089|FD-Score:6.24|P-value:2.43E-10 ID:SGTC_1803|Compound:st050068|FD-Score:4.49|P-value:3.50E-6 ID:SGTC_1812|Compound:st052057|FD-Score:4.66|P-value:1.56E-6 ID:SGTC_1845|Compound:st056753|FD-Score:3.37|P-value:3.45E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.34|P-value:3.86E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.17|P-value:7.13E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.33|P-value:6.07E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.71|P-value:9.84E-5 ID:SGTC_2162|Compound:5663267|FD-Score:-3.66|P-value:1.87E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.07|P-value:9.82E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.50|P-value:3.29E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.75|P-value:1.30E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.21|P-value:6.09E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.22|P-value:5.88E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.08|P-value:9.56E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.99|P-value:5.04E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.09|P-value:9.40E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.19|P-value:6.51E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.51|P-value:3.27E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.28|P-value:4.82E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.29|P-value:4.72E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.39|P-value:3.27E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.86|P-value:5.28E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.64|P-value:1.30E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.01|P-value:2.83E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.73|P-value:9.11E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.09|P-value:9.25E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.07|P-value:0.00100 ID:SGTC_3199|Compound:9111318|FD-Score:4.03|P-value:2.71E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.14|P-value:1.65E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.59|P-value:2.36E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.43|P-value:4.25E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.80|P-value:3.54E-9 ID:SGTC_12|Compound:0849-0099|FD-Score:3.07|P-value:9.87E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.56|P-value:2.69E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.42|P-value:2.90E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.36|P-value:3.67E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.12|P-value:8.38E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.33|P-value:7.21E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:3.72|P-value:9.26E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-4.24|P-value:1.77E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:6.95|P-value:2.13E-12 ID:SGTC_435|Compound:c-PAF|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.11|P-value:5.46E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.75|P-value:9.78E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:4.30|P-value:8.08E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:4.62|P-value:1.83E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:4.18|P-value:1.37E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:-4.03|P-value:4.32E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:5.57|P-value:1.32E-8 ID:SGTC_559|Compound:1550-0661|FD-Score:3.67|P-value:1.12E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.83|P-value:9.57E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.57|P-value:2.55E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.40|P-value:3.12E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.77|P-value:7.72E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.72|P-value:1.49E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-4.29|P-value:1.46E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:5.71|P-value:5.83E-9 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.60|P-value:2.35E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.16|P-value:7.22E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.17|P-value:7.11E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.41|P-value:4.98E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.33|P-value:6.10E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.34|P-value:5.95E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.14|P-value:1.69E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.90|P-value:4.49E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.93|P-value:4.07E-5 ID:SGTC_1801|Compound:st050089|FD-Score:6.24|P-value:2.43E-10 ID:SGTC_1803|Compound:st050068|FD-Score:4.49|P-value:3.50E-6 ID:SGTC_1812|Compound:st052057|FD-Score:4.66|P-value:1.56E-6 ID:SGTC_1845|Compound:st056753|FD-Score:3.37|P-value:3.45E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.34|P-value:3.86E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.17|P-value:7.13E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.33|P-value:6.07E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.71|P-value:9.84E-5 ID:SGTC_2162|Compound:5663267|FD-Score:-3.66|P-value:1.87E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.07|P-value:9.82E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.50|P-value:3.29E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.75|P-value:1.30E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.21|P-value:6.09E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.22|P-value:5.88E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.08|P-value:9.56E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.99|P-value:5.04E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.09|P-value:9.40E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.19|P-value:6.51E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.51|P-value:3.27E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.28|P-value:4.82E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.29|P-value:4.72E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.39|P-value:3.27E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.86|P-value:5.28E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.64|P-value:1.30E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.01|P-value:2.83E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.73|P-value:9.11E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.09|P-value:9.25E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.07|P-value:0.00100 ID:SGTC_3199|Compound:9111318|FD-Score:4.03|P-value:2.71E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.14|P-value:1.65E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.59|P-value:2.36E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.43|P-value:4.25E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.80|P-value:3.54E-9

Top fitness defect scores for YPL152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_420 mitomycin C 6.95 81.9 mM 2.13E-12 1 1.83E-12
2 SGTC_1801 st050089 6.24 28.4 µM 2.43E-10 NEO1-PIK1 46 2.23E-10
3 SGTC_439 amiodarone 6.11 34.4 µM 5.46E-10 NEO1-PIK1 46 5.07E-10
4 SGTC_3311 9131146 5.80 2.9 µM 3.54E-9 cell wall 62 3.37E-9
5 SGTC_931 2812-0076 5.71 566.0 µM 5.83E-9 3 5.58E-9
6 SGTC_558 k064-0027 5.57 21.3 µM 1.32E-8 DNA damage response 8 1.28E-8
7 SGTC_453 enantio-paf c16 4.75 10.0 µM 9.78E-7 98 9.94E-7
8 SGTC_1812 st052057 4.66 4.3 µM 1.56E-6 calcium & mitochondrial duress 12 1.59E-6
9 SGTC_517 1365-0151 4.62 113.0 µM 1.83E-6 22 1.88E-6
10 SGTC_2401 5128683 4.50 200.0 µM 3.29E-6 23 3.38E-6
11 SGTC_1803 st050068 4.49 52.4 µM 3.50E-6 NEO1-PIK1 140 3.60E-6
12 SGTC_1177 0983-0204 4.41 23.6 µM 4.98E-6 9 5.15E-6
13 SGTC_360 0957-0399 4.33 1.0 µM 7.21E-6 cell wall 34 7.48E-6
14 SGTC_514 4466-0038 4.30 2.6 nM 8.08E-6 cell wall 134 8.39E-6
15 SGTC_552 k242-0005 4.18 476.0 µM 1.37E-5 13 1.43E-5
16 SGTC_3200 9114385 4.14 49.5 µM 1.65E-5 27 1.73E-5
17 SGTC_1748 st037455 4.14 53.6 µM 1.69E-5 25 1.77E-5
18 SGTC_3199 9111318 4.03 49.5 µM 2.71E-5 18 2.84E-5
19 SGTC_2921 7974240 4.01 10.7 µM 2.83E-5 51 2.97E-5
20 SGTC_1800 st050079 3.93 29.1 µM 4.07E-5 NEO1-PIK1 124 4.29E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 9.87E-24 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.167 2.42E-22 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.150 3.00E-18 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.144 5.86E-17 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.143 6.89E-17 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.142 1.68E-16 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.141 2.75E-16 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.135 3.58E-15 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.135 4.15E-15 YBL062W_d YBL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.132 1.36E-14 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.131 2.25E-14 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.130 3.42E-14 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.130 3.71E-14 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.128 8.78E-14 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 2.28E-12 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes