YPL156C / PRM4

Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL156C / PRM4

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:-3.53|P-value:3.35E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:4.64|P-value:8.86E-8 ID:SGTC_51|Compound:1013-0126|FD-Score:3.17|P-value:1.82E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:7.43|P-value:2.85E-17 ID:SGTC_158|Compound:k038-0087|FD-Score:3.76|P-value:1.13E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.07|P-value:2.78E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.72|P-value:1.42E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.53|P-value:3.31E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.27|P-value:1.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:2.79|P-value:8.53E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.11|P-value:2.32E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.03|P-value:3.21E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.90|P-value:5.68E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.58|P-value:2.80E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.34|P-value:8.62E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.82|P-value:7.21E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.46|P-value:4.81E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.36|P-value:7.69E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.18|P-value:1.71E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:2.97|P-value:4.21E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.14|P-value:2.03E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.29|P-value:1.04E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.05|P-value:2.98E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.39|P-value:6.75E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.40|P-value:6.56E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.55|P-value:3.20E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.93|P-value:4.88E-4 ID:SGTC_1927|Compound:st060202|FD-Score:5.50|P-value:2.85E-10 ID:SGTC_1934|Compound:st074720|FD-Score:-3.09|P-value:2.39E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.14|P-value:1.58E-6 ID:SGTC_2213|Compound:7173844|FD-Score:3.06|P-value:2.82E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.61|P-value:2.35E-5 ID:SGTC_2267|Compound:7931562|FD-Score:-4.32|P-value:5.56E-7 ID:SGTC_2274|Compound:7947094|FD-Score:-5.98|P-value:7.44E-12 ID:SGTC_2278|Compound:7948257|FD-Score:2.86|P-value:6.44E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-4.01|P-value:2.98E-6 ID:SGTC_2299|Compound:7976368|FD-Score:6.01|P-value:6.36E-12 ID:SGTC_2301|Compound:7769476|FD-Score:-2.82|P-value:7.15E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.55|P-value:3.02E-5 ID:SGTC_2321|Compound:7390090|FD-Score:4.80|P-value:3.23E-8 ID:SGTC_2323|Compound:6148992|FD-Score:2.84|P-value:7.07E-4 ID:SGTC_2328|Compound:6201408|FD-Score:2.88|P-value:5.95E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-2.98|P-value:3.80E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.04|P-value:3.06E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.40|P-value:6.36E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.96|P-value:4.12E-6 ID:SGTC_2433|Compound:5607874|FD-Score:6.05|P-value:4.66E-12 ID:SGTC_2441|Compound:5730946|FD-Score:4.05|P-value:2.54E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.69|P-value:1.65E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-2.91|P-value:5.09E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.79|P-value:8.47E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.17|P-value:1.70E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.80|P-value:9.29E-6 ID:SGTC_2967|Compound:9089538|FD-Score:4.40|P-value:3.52E-7 ID:SGTC_2971|Compound:9092186|FD-Score:-3.18|P-value:1.64E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.99|P-value:3.63E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.40|P-value:6.32E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-3.35|P-value:7.71E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.09|P-value:2.57E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.59|P-value:1.20E-7 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.53|P-value:3.35E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:4.64|P-value:8.86E-8 ID:SGTC_51|Compound:1013-0126|FD-Score:3.17|P-value:1.82E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:7.43|P-value:2.85E-17 ID:SGTC_158|Compound:k038-0087|FD-Score:3.76|P-value:1.13E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.07|P-value:2.78E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.72|P-value:1.42E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.53|P-value:3.31E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.27|P-value:1.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:2.79|P-value:8.53E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.11|P-value:2.32E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.03|P-value:3.21E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.90|P-value:5.68E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.58|P-value:2.80E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.34|P-value:8.62E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.82|P-value:7.21E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.46|P-value:4.81E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.36|P-value:7.69E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.18|P-value:1.71E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:2.97|P-value:4.21E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.14|P-value:2.03E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.29|P-value:1.04E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.05|P-value:2.98E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.39|P-value:6.75E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.40|P-value:6.56E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.55|P-value:3.20E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.93|P-value:4.88E-4 ID:SGTC_1927|Compound:st060202|FD-Score:5.50|P-value:2.85E-10 ID:SGTC_1934|Compound:st074720|FD-Score:-3.09|P-value:2.39E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.14|P-value:1.58E-6 ID:SGTC_2213|Compound:7173844|FD-Score:3.06|P-value:2.82E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.61|P-value:2.35E-5 ID:SGTC_2267|Compound:7931562|FD-Score:-4.32|P-value:5.56E-7 ID:SGTC_2274|Compound:7947094|FD-Score:-5.98|P-value:7.44E-12 ID:SGTC_2278|Compound:7948257|FD-Score:2.86|P-value:6.44E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-4.01|P-value:2.98E-6 ID:SGTC_2299|Compound:7976368|FD-Score:6.01|P-value:6.36E-12 ID:SGTC_2301|Compound:7769476|FD-Score:-2.82|P-value:7.15E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.55|P-value:3.02E-5 ID:SGTC_2321|Compound:7390090|FD-Score:4.80|P-value:3.23E-8 ID:SGTC_2323|Compound:6148992|FD-Score:2.84|P-value:7.07E-4 ID:SGTC_2328|Compound:6201408|FD-Score:2.88|P-value:5.95E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-2.98|P-value:3.80E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.04|P-value:3.06E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.40|P-value:6.36E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.96|P-value:4.12E-6 ID:SGTC_2433|Compound:5607874|FD-Score:6.05|P-value:4.66E-12 ID:SGTC_2441|Compound:5730946|FD-Score:4.05|P-value:2.54E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.69|P-value:1.65E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-2.91|P-value:5.09E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.79|P-value:8.47E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.17|P-value:1.70E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.80|P-value:9.29E-6 ID:SGTC_2967|Compound:9089538|FD-Score:4.40|P-value:3.52E-7 ID:SGTC_2971|Compound:9092186|FD-Score:-3.18|P-value:1.64E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.99|P-value:3.63E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.40|P-value:6.32E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-3.35|P-value:7.71E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.09|P-value:2.57E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.59|P-value:1.20E-7

Top fitness defect scores for YPL156C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_67 0335-0847 7.43 266.0 µM 2.85E-17 ubiquinone biosynthesis & proteasome 44 5.39E-14
2 SGTC_2433 5607874 6.05 27.8 µM 4.66E-12 3 7.17E-10
3 SGTC_2299 7976368 6.01 114.9 µM 6.36E-12 8 9.18E-10
4 SGTC_1927 st060202 5.50 13.8 µM 2.85E-10 3 1.86E-8
5 SGTC_2321 7390090 4.80 138.8 µM 3.23E-8 13 7.95E-7
6 SGTC_49 0717-0965 4.64 32.1 µM 8.86E-8 60S ribosome export 11 1.77E-6
7 SGTC_3210 9128157 4.59 49.5 µM 1.20E-7 31 2.25E-6
8 SGTC_2967 9089538 4.40 49.9 µM 3.52E-7 22 5.30E-6
9 SGTC_2211 7117706 4.14 200.0 µM 1.58E-6 9 1.75E-5
10 SGTC_2441 5730946 4.05 39.1 µM 2.54E-6 14 2.55E-5
11 SGTC_2410 aloe-emodin-8-o-glycoside 3.96 46.3 µM 4.12E-6 mitochondrial processes 31 3.75E-5
12 SGTC_1088 bifonazole 3.90 369.0 nM 5.68E-6 17 4.84E-5
13 SGTC_2806 7952793 3.80 58.4 µM 9.29E-6 26 7.17E-5
14 SGTC_158 k038-0087 3.76 26.4 µM 1.13E-5 ubiquinone biosynthesis & proteasome 153 8.40E-5
15 SGTC_505 gw-5074 3.72 63.9 µM 1.42E-5 67 1.01E-4
16 SGTC_2506 ethyl hematommate 3.69 54.2 µM 1.65E-5 RPP1 & pyrimidine depletion 20 1.13E-4
17 SGTC_1183 1254-0324 3.58 198.0 µM 2.80E-5 34 1.73E-4
18 SGTC_1731 st035964 3.55 63.0 µM 3.20E-5 44 1.92E-4
19 SGTC_2998 9066762 3.40 71.4 µM 6.32E-5 RPP1 & pyrimidine depletion 43 3.31E-4
20 SGTC_2398 5228213 3.40 48.8 µM 6.36E-5 iron homeostasis 68 3.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 2.98E-28 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.186 2.25E-27 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.159 1.57E-20 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.155 1.61E-19 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.154 2.81E-19 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.135 4.55E-15 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.133 8.96E-15 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.130 4.78E-14 YPL153C RAD53 het Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
0.126 2.61E-13 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.117 1.22E-11 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.116 1.56E-11 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.116 1.75E-11 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.113 5.18E-11 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.110 1.64E-10 YLR007W NSE1 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.108 2.97E-10 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER