YPL159C / PET20

Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL159C / PET20

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.02|P-value:4.78E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:-3.49|P-value:3.50E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.41|P-value:4.58E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.52|P-value:3.10E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.90|P-value:7.86E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:3.38|P-value:5.24E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.50|P-value:6.34E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:3.80|P-value:1.17E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.90|P-value:1.03E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.83|P-value:1.01E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.79|P-value:1.17E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.53|P-value:3.04E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.50|P-value:6.52E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.40|P-value:4.89E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.31|P-value:6.59E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.96|P-value:6.14E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.34|P-value:6.07E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.86|P-value:9.24E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.46|P-value:4.02E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.83|P-value:1.01E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.43|P-value:4.51E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.22|P-value:2.14E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.69|P-value:1.74E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.90|P-value:7.60E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-3.32|P-value:6.25E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.30|P-value:6.81E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-3.31|P-value:6.62E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.93|P-value:9.17E-12 ID:SGTC_2035|Compound:5154463|FD-Score:3.78|P-value:1.26E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.49|P-value:3.60E-4 ID:SGTC_2158|Compound:5657123|FD-Score:4.02|P-value:4.93E-5 ID:SGTC_2192|Compound:5915882|FD-Score:3.74|P-value:1.46E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.83|P-value:1.41E-6 ID:SGTC_2207|Compound:7258803|FD-Score:4.91|P-value:9.64E-7 ID:SGTC_2215|Compound:7188065|FD-Score:3.59|P-value:2.53E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.54|P-value:5.28E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.37|P-value:5.38E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.58|P-value:2.49E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.72|P-value:1.49E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.34|P-value:6.05E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.33|P-value:6.15E-4 ID:SGTC_3153|Compound:9100258|FD-Score:9.97|P-value:1.95E-22 ID:SGTC_3157|Compound:9099274|FD-Score:3.25|P-value:8.27E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.86|P-value:1.46E-11 ID:SGTC_3306|Compound:9127676|FD-Score:4.03|P-value:4.72E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.54|P-value:3.06E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.02|P-value:4.78E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:-3.49|P-value:3.50E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.41|P-value:4.58E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.52|P-value:3.10E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.90|P-value:7.86E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:3.38|P-value:5.24E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.50|P-value:6.34E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:3.80|P-value:1.17E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.90|P-value:1.03E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.83|P-value:1.01E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.79|P-value:1.17E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.53|P-value:3.04E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.50|P-value:6.52E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.40|P-value:4.89E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.31|P-value:6.59E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.96|P-value:6.14E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.34|P-value:6.07E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.86|P-value:9.24E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.46|P-value:4.02E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.83|P-value:1.01E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.43|P-value:4.51E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.22|P-value:2.14E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.69|P-value:1.74E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.90|P-value:7.60E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-3.32|P-value:6.25E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.30|P-value:6.81E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-3.31|P-value:6.62E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.93|P-value:9.17E-12 ID:SGTC_2035|Compound:5154463|FD-Score:3.78|P-value:1.26E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.49|P-value:3.60E-4 ID:SGTC_2158|Compound:5657123|FD-Score:4.02|P-value:4.93E-5 ID:SGTC_2192|Compound:5915882|FD-Score:3.74|P-value:1.46E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.83|P-value:1.41E-6 ID:SGTC_2207|Compound:7258803|FD-Score:4.91|P-value:9.64E-7 ID:SGTC_2215|Compound:7188065|FD-Score:3.59|P-value:2.53E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.54|P-value:5.28E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.37|P-value:5.38E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.58|P-value:2.49E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.72|P-value:1.49E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.34|P-value:6.05E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.33|P-value:6.15E-4 ID:SGTC_3153|Compound:9100258|FD-Score:9.97|P-value:1.95E-22 ID:SGTC_3157|Compound:9099274|FD-Score:3.25|P-value:8.27E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.86|P-value:1.46E-11 ID:SGTC_3306|Compound:9127676|FD-Score:4.03|P-value:4.72E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.54|P-value:3.06E-4

Top fitness defect scores for YPL159C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3153 9100258 9.97 49.5 µM 1.95E-22 1 9.91E-24
2 SGTC_2006 4011487 6.93 200.0 µM 9.17E-12 endomembrane recycling 35 2.13E-12
3 SGTC_3202 9113761 6.86 49.5 µM 1.46E-11 5 3.48E-12
4 SGTC_2207 7258803 4.91 200.0 µM 9.64E-7 2 4.54E-7
5 SGTC_609 0986-0026 4.90 86.3 µM 1.03E-6 calcium & mitochondrial duress 13 4.89E-7
6 SGTC_2200 6600604 4.83 21.9 µM 1.41E-6 tubulin folding & SWR complex 37 6.80E-7
7 SGTC_2661 dactinomycin 4.54 13.0 µM 5.28E-6 redox potentiating 10 2.76E-6
8 SGTC_568 1193-0097 4.50 7.5 µM 6.34E-6 ERAD & cell cycle 111 3.35E-6
9 SGTC_808 0711-0032 4.50 135.0 µM 6.52E-6 6 3.45E-6
10 SGTC_1742 st038235 4.22 28.9 µM 2.14E-5 mitochondrial stress 108 1.22E-5
11 SGTC_3306 9127676 4.03 59.8 µM 4.72E-5 19 2.81E-5
12 SGTC_10 0279-0212 4.02 42.6 µM 4.78E-5 TRP & mitochondrial translation 116 2.85E-5
13 SGTC_2158 5657123 4.02 3.6 µM 4.93E-5 5 2.94E-5
14 SGTC_1203 3992-3522 3.96 103.0 µM 6.14E-5 32 3.71E-5
15 SGTC_169 k015-0017 3.90 16.0 µM 7.86E-5 21 4.83E-5
16 SGTC_1530 rhein 3.86 70.4 µM 9.24E-5 23 5.73E-5
17 SGTC_1637 st007924 3.83 17.4 µM 1.01E-4 23 6.30E-5
18 SGTC_601 0986-0029 3.80 62.9 µM 1.17E-4 calcium & mitochondrial duress 41 7.35E-5
19 SGTC_2035 5154463 3.78 94.6 µM 1.26E-4 18 7.97E-5
20 SGTC_2192 5915882 3.74 198.5 µM 1.46E-4 RNA processing & uracil transport 30 9.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 4.76E-13 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.110 1.47E-10 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.110 1.64E-10 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.106 7.06E-10 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.103 2.47E-9 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.102 2.69E-9 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.098 1.28E-8 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.097 2.08E-8 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.091 1.46E-7 YDR180W SCC2 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin
0.090 1.76E-7 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene
0.090 1.99E-7 YHR158C KEL1 hom Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
0.087 4.50E-7 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.087 4.90E-7 YMR013C SEC59 het Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
0.086 5.26E-7 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.084 9.88E-7 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication