YPL160W / CDC60

Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL160W / CDC60

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.90|P-value:4.71E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:2.93|P-value:7.06E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.39|P-value:1.10E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.14|P-value:1.05E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.38|P-value:1.23E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.24|P-value:1.95E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:3.10|P-value:3.58E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:6.62|P-value:2.71E-13 ID:SGTC_266|Compound:formosanin C|FD-Score:2.95|P-value:6.36E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.56|P-value:3.34E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:4.15|P-value:3.11E-6 ID:SGTC_329|Compound:k048-0121|FD-Score:2.97|P-value:6.00E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.88|P-value:8.40E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.06|P-value:4.19E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.36|P-value:1.23E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.00|P-value:5.60E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:4.52|P-value:4.25E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.61|P-value:4.41E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:3.45|P-value:8.30E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:3.92|P-value:9.60E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:3.27|P-value:1.80E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.21|P-value:2.48E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.92|P-value:1.02E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.37|P-value:1.28E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.76|P-value:2.25E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.31|P-value:1.52E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:2.97|P-value:5.93E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.87|P-value:8.84E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.34|P-value:1.11E-6 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.10|P-value:3.55E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.05|P-value:4.37E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.25|P-value:1.96E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:2.95|P-value:6.38E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-2.88|P-value:8.98E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.78|P-value:2.04E-5 ID:SGTC_2075|Compound:5212009|FD-Score:4.31|P-value:1.34E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-4.59|P-value:3.11E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.04|P-value:4.63E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.33|P-value:1.42E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.72|P-value:1.31E-7 ID:SGTC_2403|Compound:6032726|FD-Score:6.06|P-value:2.00E-11 ID:SGTC_2526|Compound:patulin|FD-Score:2.90|P-value:7.89E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.48|P-value:5.14E-7 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:5.33|P-value:3.10E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.33|P-value:1.19E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.22|P-value:2.15E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:2.96|P-value:6.26E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.67|P-value:1.79E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.41|P-value:9.97E-5 ID:SGTC_2692|Compound:st077426|FD-Score:2.94|P-value:6.79E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.40|P-value:1.06E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.04|P-value:4.66E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.99|P-value:7.33E-6 ID:SGTC_3066|Compound:9117245|FD-Score:-4.97|P-value:3.50E-8 ID:SGTC_3085|Compound:9117376|FD-Score:3.84|P-value:1.43E-5 ID:SGTC_3116|Compound:9124943|FD-Score:12.50|P-value:2.87E-42 ID:SGTC_3124|Compound:9127567|FD-Score:-3.49|P-value:7.78E-5 ID:SGTC_3179|Compound:9107801|FD-Score:2.99|P-value:5.57E-4 ID:SGTC_3268|Compound:9137683|FD-Score:2.84|P-value:9.68E-4 ID:SGTC_3299|Compound:9121982|FD-Score:24.00|P-value:1.31E-150 ID:SGTC_36|Compound:0335-0881|FD-Score:4.90|P-value:4.71E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:2.93|P-value:7.06E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.39|P-value:1.10E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.14|P-value:1.05E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.38|P-value:1.23E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.24|P-value:1.95E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:3.10|P-value:3.58E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:6.62|P-value:2.71E-13 ID:SGTC_266|Compound:formosanin C|FD-Score:2.95|P-value:6.36E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.56|P-value:3.34E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:4.15|P-value:3.11E-6 ID:SGTC_329|Compound:k048-0121|FD-Score:2.97|P-value:6.00E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.88|P-value:8.40E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.06|P-value:4.19E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.36|P-value:1.23E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.00|P-value:5.60E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:4.52|P-value:4.25E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.61|P-value:4.41E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:3.45|P-value:8.30E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:3.92|P-value:9.60E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:3.27|P-value:1.80E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.21|P-value:2.48E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.92|P-value:1.02E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.37|P-value:1.28E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.76|P-value:2.25E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.31|P-value:1.52E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:2.97|P-value:5.93E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.87|P-value:8.84E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.34|P-value:1.11E-6 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.10|P-value:3.55E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.05|P-value:4.37E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.25|P-value:1.96E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:2.95|P-value:6.38E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-2.88|P-value:8.98E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.78|P-value:2.04E-5 ID:SGTC_2075|Compound:5212009|FD-Score:4.31|P-value:1.34E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-4.59|P-value:3.11E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.04|P-value:4.63E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.33|P-value:1.42E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.72|P-value:1.31E-7 ID:SGTC_2403|Compound:6032726|FD-Score:6.06|P-value:2.00E-11 ID:SGTC_2526|Compound:patulin|FD-Score:2.90|P-value:7.89E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.48|P-value:5.14E-7 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:5.33|P-value:3.10E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.33|P-value:1.19E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.22|P-value:2.15E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:2.96|P-value:6.26E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.67|P-value:1.79E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.41|P-value:9.97E-5 ID:SGTC_2692|Compound:st077426|FD-Score:2.94|P-value:6.79E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.40|P-value:1.06E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.04|P-value:4.66E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.99|P-value:7.33E-6 ID:SGTC_3066|Compound:9117245|FD-Score:-4.97|P-value:3.50E-8 ID:SGTC_3085|Compound:9117376|FD-Score:3.84|P-value:1.43E-5 ID:SGTC_3116|Compound:9124943|FD-Score:12.50|P-value:2.87E-42 ID:SGTC_3124|Compound:9127567|FD-Score:-3.49|P-value:7.78E-5 ID:SGTC_3179|Compound:9107801|FD-Score:2.99|P-value:5.57E-4 ID:SGTC_3268|Compound:9137683|FD-Score:2.84|P-value:9.68E-4 ID:SGTC_3299|Compound:9121982|FD-Score:24.00|P-value:1.31E-150

Top fitness defect scores for YPL160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3299 9121982 24.00 43.1 µM 1.31E-150 1 1.43E-127 15.70
2 SGTC_3116 9124943 12.50 49.5 µM 2.87E-42 1 5.40E-36 8.15
3 SGTC_256 clotrimazole 6.62 625.0 nM 2.71E-13 ergosterol depletion effects on membrane 7 1.74E-11 0.05
4 SGTC_2403 6032726 6.06 181.2 µM 2.00E-11 1 6.68E-10 1.14
5 SGTC_2536 dehydroabietamide 5.33 32.0 µM 3.10E-9 3 4.80E-8 0.51
6 SGTC_103 0844-0104 5.14 51.8 µM 1.05E-8 ERAD & cell cycle 34 1.35E-7 0.01
7 SGTC_36 0335-0881 4.90 14.2 µM 4.71E-8 ubiquinone biosynthesis & proteasome 23 4.83E-7 0.03
8 SGTC_2320 7373003 4.72 200.0 µM 1.31E-7 5 1.15E-6 0.29
9 SGTC_2651 1327-0036 4.67 5.0 µM 1.79E-7 41 1.50E-6 0.14
10 SGTC_268 camptothecin 4.56 39.6 µM 3.34E-7 DNA damage response 36 2.55E-6 0.02
11 SGTC_593 1203-0218 4.52 61.7 µM 4.25E-7 2 3.12E-6 0.15
12 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.48 63.6 µM 5.14E-7 5 3.67E-6 0.07
13 SGTC_1161 k007-0610 4.34 110.0 µM 1.11E-6 ERAD & cell cycle 35 7.06E-6 0.09
14 SGTC_2612 dictamnine 4.33 15.5 µM 1.19E-6 RNA pol III & RNase P/MRP 26 7.46E-6 0.01
15 SGTC_2075 5212009 4.31 200.0 µM 1.34E-6 4 8.28E-6 0.41
16 SGTC_137 0438-0332 4.24 85.4 µM 1.95E-6 ubiquinone biosynthesis & proteasome 35 1.14E-5 0.02
17 SGTC_2615 purpurogallin-4-carboxylic acid 4.22 100.0 µM 2.15E-6 redox potentiating 6 1.24E-5 0.17
18 SGTC_294 k038-0071 4.15 157.0 µM 3.11E-6 ubiquinone biosynthesis & proteasome 11 1.69E-5 0.12
19 SGTC_928 2764-0428 3.92 58.7 µM 9.60E-6 cell wall 20 4.41E-5 0.16
20 SGTC_3085 9117376 3.84 49.5 µM 1.43E-5 8 6.18E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 3.12E-33 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.194 8.62E-30 YNR051C BRE5 hom Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
0.180 6.53E-26 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.176 8.16E-25 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.165 6.47E-22 YGR244C LSC2 hom Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
0.164 1.34E-21 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.153 4.01E-19 YIL005W EPS1 hom ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
0.145 3.61E-17 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.144 4.33E-17 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.142 1.25E-16 YHR094C HXT1 hom Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication
0.137 1.78E-15 YLR088W GAA1 het Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
0.135 3.90E-15 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.134 5.97E-15 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.132 1.86E-14 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.131 2.49E-14 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p