YPL161C / BEM4

Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL161C / BEM4

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:4.49|P-value:3.36E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.69|P-value:6.97E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.18|P-value:1.13E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.63|P-value:1.89E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:4.27|P-value:6.22E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.07|P-value:5.73E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.65|P-value:7.92E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.37|P-value:4.64E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.72|P-value:1.67E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.90|P-value:7.57E-4 ID:SGTC_458|Compound:nppb|FD-Score:4.46|P-value:3.63E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:8.26|P-value:1.02E-10 ID:SGTC_548|Compound:1436-0017|FD-Score:4.88|P-value:1.04E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.90|P-value:9.78E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.49|P-value:3.31E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.86|P-value:7.03E-8 ID:SGTC_639|Compound:0833-0042|FD-Score:4.47|P-value:3.52E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-4.69|P-value:7.66E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:4.23|P-value:6.93E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.19|P-value:7.57E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.97|P-value:6.31E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.86|P-value:8.51E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.89|P-value:1.02E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.64|P-value:2.14E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.52|P-value:3.06E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:4.89|P-value:1.01E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.30|P-value:5.72E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.46|P-value:3.60E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.90|P-value:3.23E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.69|P-value:1.86E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.31|P-value:5.59E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:7.76|P-value:1.23E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:-5.79|P-value:1.64E-6 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.21|P-value:7.24E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.16|P-value:3.68E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.10|P-value:9.76E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:6.42|P-value:4.44E-7 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.18|P-value:7.84E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.36|P-value:4.81E-4 ID:SGTC_1764|Compound:st044502|FD-Score:6.25|P-value:8.80E-7 ID:SGTC_1812|Compound:st052057|FD-Score:4.74|P-value:1.61E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.38|P-value:1.61E-7 ID:SGTC_1853|Compound:st056710|FD-Score:4.51|P-value:3.14E-4 ID:SGTC_1884|Compound:5633444|FD-Score:6.42|P-value:4.48E-7 ID:SGTC_1932|Compound:st074806|FD-Score:4.37|P-value:4.63E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.90|P-value:7.61E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.11|P-value:4.30E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.80|P-value:9.88E-4 ID:SGTC_2085|Compound:5307070|FD-Score:6.97|P-value:4.47E-8 ID:SGTC_2089|Compound:5281248|FD-Score:7.31|P-value:9.83E-9 ID:SGTC_2189|Compound:6047310|FD-Score:5.11|P-value:5.09E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.11|P-value:5.08E-5 ID:SGTC_2283|Compound:7944793|FD-Score:4.64|P-value:2.13E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.86|P-value:1.10E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-4.53|P-value:1.26E-4 ID:SGTC_2430|Compound:5571206|FD-Score:6.52|P-value:2.99E-7 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.69|P-value:1.83E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.26|P-value:3.08E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.28|P-value:6.07E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.22|P-value:7.07E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.40|P-value:6.91E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.07|P-value:5.65E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-6.32|P-value:2.04E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.83|P-value:9.11E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.51|P-value:3.10E-4 ID:SGTC_2715|Compound:st079500|FD-Score:4.57|P-value:2.63E-4 ID:SGTC_2716|Compound:st080858|FD-Score:5.77|P-value:5.24E-6 ID:SGTC_2717|Compound:st081029|FD-Score:4.69|P-value:1.84E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.41|P-value:4.16E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:6.23|P-value:9.32E-7 ID:SGTC_2817|Compound:7995342|FD-Score:4.37|P-value:4.72E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.70|P-value:6.68E-6 ID:SGTC_2851|Compound:9015922|FD-Score:4.12|P-value:9.28E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.91|P-value:7.48E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.17|P-value:8.06E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-4.32|P-value:2.37E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-4.81|P-value:5.12E-5 ID:SGTC_3296|Compound:9122258|FD-Score:4.47|P-value:3.49E-4 ID:SGTC_3304|Compound:9125678|FD-Score:5.05|P-value:6.02E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:4.49|P-value:3.36E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.69|P-value:6.97E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.18|P-value:1.13E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.63|P-value:1.89E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:4.27|P-value:6.22E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.07|P-value:5.73E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.65|P-value:7.92E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.37|P-value:4.64E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.72|P-value:1.67E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.90|P-value:7.57E-4 ID:SGTC_458|Compound:nppb|FD-Score:4.46|P-value:3.63E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:8.26|P-value:1.02E-10 ID:SGTC_548|Compound:1436-0017|FD-Score:4.88|P-value:1.04E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.90|P-value:9.78E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.49|P-value:3.31E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.86|P-value:7.03E-8 ID:SGTC_639|Compound:0833-0042|FD-Score:4.47|P-value:3.52E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-4.69|P-value:7.66E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:4.23|P-value:6.93E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.19|P-value:7.57E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.97|P-value:6.31E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.86|P-value:8.51E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.89|P-value:1.02E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.64|P-value:2.14E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.52|P-value:3.06E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:4.89|P-value:1.01E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.30|P-value:5.72E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.46|P-value:3.60E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.90|P-value:3.23E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.69|P-value:1.86E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.31|P-value:5.59E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:7.76|P-value:1.23E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:-5.79|P-value:1.64E-6 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.21|P-value:7.24E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.16|P-value:3.68E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.10|P-value:9.76E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:6.42|P-value:4.44E-7 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.18|P-value:7.84E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.36|P-value:4.81E-4 ID:SGTC_1764|Compound:st044502|FD-Score:6.25|P-value:8.80E-7 ID:SGTC_1812|Compound:st052057|FD-Score:4.74|P-value:1.61E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.38|P-value:1.61E-7 ID:SGTC_1853|Compound:st056710|FD-Score:4.51|P-value:3.14E-4 ID:SGTC_1884|Compound:5633444|FD-Score:6.42|P-value:4.48E-7 ID:SGTC_1932|Compound:st074806|FD-Score:4.37|P-value:4.63E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.90|P-value:7.61E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.11|P-value:4.30E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.80|P-value:9.88E-4 ID:SGTC_2085|Compound:5307070|FD-Score:6.97|P-value:4.47E-8 ID:SGTC_2089|Compound:5281248|FD-Score:7.31|P-value:9.83E-9 ID:SGTC_2189|Compound:6047310|FD-Score:5.11|P-value:5.09E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.11|P-value:5.08E-5 ID:SGTC_2283|Compound:7944793|FD-Score:4.64|P-value:2.13E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.86|P-value:1.10E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-4.53|P-value:1.26E-4 ID:SGTC_2430|Compound:5571206|FD-Score:6.52|P-value:2.99E-7 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.69|P-value:1.83E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.26|P-value:3.08E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.28|P-value:6.07E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.22|P-value:7.07E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.40|P-value:6.91E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.07|P-value:5.65E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-6.32|P-value:2.04E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.83|P-value:9.11E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.51|P-value:3.10E-4 ID:SGTC_2715|Compound:st079500|FD-Score:4.57|P-value:2.63E-4 ID:SGTC_2716|Compound:st080858|FD-Score:5.77|P-value:5.24E-6 ID:SGTC_2717|Compound:st081029|FD-Score:4.69|P-value:1.84E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.41|P-value:4.16E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:6.23|P-value:9.32E-7 ID:SGTC_2817|Compound:7995342|FD-Score:4.37|P-value:4.72E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.70|P-value:6.68E-6 ID:SGTC_2851|Compound:9015922|FD-Score:4.12|P-value:9.28E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.91|P-value:7.48E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.17|P-value:8.06E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-4.32|P-value:2.37E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-4.81|P-value:5.12E-5 ID:SGTC_3296|Compound:9122258|FD-Score:4.47|P-value:3.49E-4 ID:SGTC_3304|Compound:9125678|FD-Score:5.05|P-value:6.02E-5

Top fitness defect scores for YPL161C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_525 k781-2675 8.26 26.7 µM 1.02E-10 redox potentiating 11 7.27E-17
2 SGTC_1129 3453-1384 7.76 223.0 µM 1.23E-9 4 4.32E-15
3 SGTC_2089 5281248 7.31 129.7 µM 9.83E-9 superoxide 5 1.32E-13
4 SGTC_2085 5307070 6.97 144.1 µM 4.47E-8 superoxide 4 1.58E-12
5 SGTC_625 k213-0058 6.86 121.0 µM 7.03E-8 translation 24 3.34E-12
6 SGTC_138 0850-0259 6.63 40.9 µM 1.89E-7 cell wall 86 1.69E-11
7 SGTC_2430 5571206 6.52 200.0 µM 2.99E-7 17 3.60E-11
8 SGTC_1467 k284-1082 6.42 293.0 µM 4.44E-7 1 6.89E-11
9 SGTC_1884 5633444 6.42 25.0 µM 4.48E-7 redox potentiating 25 6.98E-11
10 SGTC_1764 st044502 6.25 93.5 µM 8.80E-7 6 2.12E-10
11 SGTC_2747 doxorubicin 6.23 7.6 µM 9.32E-7 anthracycline transcription coupled DNA repair 1 2.32E-10
12 SGTC_102 gallobenzophenone 6.18 83.6 µM 1.13E-6 redox potentiating 12 3.21E-10
13 SGTC_1002 4049-0206 5.90 172.0 µM 3.23E-6 6 1.79E-9
14 SGTC_2716 st080858 5.77 38.6 µM 5.24E-6 60S ribosome export 3 3.96E-9
15 SGTC_2824 7998404 5.70 52.0 µM 6.68E-6 8 5.89E-9
16 SGTC_58 0957-0393 5.69 9.0 µM 6.97E-6 cell wall 229 6.32E-9
17 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 5.65 4.6 µM 7.92E-6 heat shock/prefoldin 16 7.80E-9
18 SGTC_2510 benzyl isothiocyanate 5.26 8.3 µM 3.08E-5 10 7.23E-8
19 SGTC_2233 sulbentine 5.11 40.4 µM 5.08E-5 32 1.65E-7
20 SGTC_2189 6047310 5.11 154.4 µM 5.09E-5 RPP1 & pyrimidine depletion 6 1.65E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 5.55E-24 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.161 6.37E-21 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.138 1.20E-15 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.135 4.93E-15 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.121 1.88E-12 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.121 2.09E-12 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.118 8.35E-12 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.114 3.27E-11 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.108 2.97E-10 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.108 3.59E-10 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.108 3.87E-10 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.107 4.77E-10 YCL037C SRO9 hom Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
0.107 5.86E-10 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.107 6.03E-10 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.106 7.13E-10 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis